5VOX
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![BU of 5vox by Molmil](/molmil-images/mine/5vox) | Yeast V-ATPase in complex with Legionella pneumophila effector SidK (rotational state 1) | Descriptor: | V-type proton ATPase catalytic subunit A,V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Zhao, J. | Deposit date: | 2017-05-03 | Release date: | 2017-06-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathog., 13, 2017
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5W21
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![BU of 5w21 by Molmil](/molmil-images/mine/5w21) | Crystal Structure of a 1:1:1 FGF23-FGFR1c-aKlotho Ternary Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ... | Authors: | Mohammadi, M. | Deposit date: | 2017-06-05 | Release date: | 2018-01-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling. Nature, 553, 2018
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8V2D
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![BU of 8v2d by Molmil](/molmil-images/mine/8v2d) | Computational Designed Nanocage O43_129 | Descriptor: | O43_129 component A, O43_129 component B | Authors: | Weidle, C, Kibler, R.D. | Deposit date: | 2023-11-22 | Release date: | 2024-03-13 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (6.77 Å) | Cite: | Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
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8IJ1
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![BU of 8ij1 by Molmil](/molmil-images/mine/8ij1) | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | Descriptor: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | Authors: | Dai, Z, Liang, L, Yin, Y.X. | Deposit date: | 2023-02-24 | Release date: | 2024-02-28 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
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8V3B
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8Z50
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![BU of 8z50 by Molmil](/molmil-images/mine/8z50) | Crystal structure of the ASF1-H3T-H4 complex | Descriptor: | Histone H3.1t, Histone H4, Histone chaperone ASF1A | Authors: | Xu, L. | Deposit date: | 2024-04-18 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into instability of the nucleosome driven by histone variant H3T. Biochem.Biophys.Res.Commun., 727, 2024
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5TVX
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5WOP
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![BU of 5wop by Molmil](/molmil-images/mine/5wop) | High Resolution Structure of Mutant CA09-PB2cap | Descriptor: | GLYCEROL, Polymerase PB2 | Authors: | Constantinides, A.E, Gumpper, R.H, Severin, C, Luo, M. | Deposit date: | 2017-08-02 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding. Acta Crystallogr F Struct Biol Commun, 74, 2018
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5Z2M
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![BU of 5z2m by Molmil](/molmil-images/mine/5z2m) | Structure of Orp1L/Rab7 complex | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Oxysterol-binding protein-related protein 1, ... | Authors: | Ma, X.L, Liu, K, Li, J, Li, H.H, Li, J, Yang, C.L, Liang, H.H. | Deposit date: | 2018-01-03 | Release date: | 2018-08-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.142 Å) | Cite: | A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning. J. Biol. Chem., 293, 2018
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5TVU
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5UBB
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![BU of 5ubb by Molmil](/molmil-images/mine/5ubb) | Crystal structure of human alpha N-terminal protein methyltransferase 1B | Descriptor: | Alpha N-terminal protein methyltransferase 1B, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION | Authors: | Dong, C, Zhu, L, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2016-12-20 | Release date: | 2017-03-22 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol, 1, 2018
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5VY6
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![BU of 5vy6 by Molmil](/molmil-images/mine/5vy6) | A self-assembling D-form DNA crystal lattice | Descriptor: | DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*GP*AP*AP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*CP*A)-3'), ... | Authors: | Simmons, C.R, Yan, H. | Deposit date: | 2017-05-24 | Release date: | 2017-08-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.064 Å) | Cite: | Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. J. Am. Chem. Soc., 139, 2017
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3TWC
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![BU of 3twc by Molmil](/molmil-images/mine/3twc) | |
3TYG
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![BU of 3tyg by Molmil](/molmil-images/mine/3tyg) | Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3) | Descriptor: | Envelope glycoprotein gp160, PGT128 heavy chain, Ig gamma-1 chain C region, ... | Authors: | Pejchal, R, Huang, P.S, Schief, W.R, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2011-09-25 | Release date: | 2011-10-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science, 334, 2011
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6KUU
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![BU of 6kuu by Molmil](/molmil-images/mine/6kuu) | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) | Descriptor: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | Authors: | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | Deposit date: | 2019-09-02 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published
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8I3V
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![BU of 8i3v by Molmil](/molmil-images/mine/8i3v) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant escitalopram in an inward-open state at resolution of 2.85 angstrom. | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2023-01-18 | Release date: | 2024-07-03 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 2024
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7EIU
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![BU of 7eiu by Molmil](/molmil-images/mine/7eiu) | Crystal structure of Mei2 RRM3 in complex with 8mer meiRNA | Descriptor: | GLYCEROL, Meiosis protein mei2, RNA (5'-R(P*UP*UP*CP*UP*GP*C)-3') | Authors: | Shen, S.Y, Lv, M.Q. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein. J Mol Cell Biol, 14, 2022
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7EIO
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![BU of 7eio by Molmil](/molmil-images/mine/7eio) | Crystal Structure of Mei2 RRM3 | Descriptor: | GLYCEROL, Meiosis protein mei2, SULFATE ION | Authors: | Shen, S.Y, Li, F.D. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.895 Å) | Cite: | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein. J Mol Cell Biol, 14, 2022
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7EMJ
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![BU of 7emj by Molmil](/molmil-images/mine/7emj) | Crystal structure of T2R-TTL-Barbigerone complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one, CALCIUM ION, ... | Authors: | Yang, J.H, Yan, W. | Deposit date: | 2021-04-14 | Release date: | 2022-04-20 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Phytomedicine, 109, 2023
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7EWQ
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![BU of 7ewq by Molmil](/molmil-images/mine/7ewq) | Structure of Mumps virus nucleocapsid ring | Descriptor: | Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | Authors: | Su, X, Shen, Q, Shan, H. | Deposit date: | 2021-05-25 | Release date: | 2021-06-23 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural plasticity of mumps virus nucleocapsids with cryo-EM structures. Commun Biol, 4, 2021
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4GEV
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![BU of 4gev by Molmil](/molmil-images/mine/4gev) | E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, Thymidylate synthase | Authors: | Newby, Z, Lee, T.T, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2012-08-02 | Release date: | 2012-08-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J.Am.Chem.Soc., 134, 2012
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8GA7
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8G9J
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8K5N
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![BU of 8k5n by Molmil](/molmil-images/mine/8k5n) | Discovery of Novel PD-L1 Inhibitors That Induce Dimerization and Degradation of PD-L1 Based on Fragment Coupling Strategy | Descriptor: | 3-[(1~{S})-1-[6-methoxy-3-methyl-5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]oxy-2,3-dihydro-1~{H}-inden-4-yl]-2-methyl-~{N}-[5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyridin-2-yl]benzamide, Programmed cell death 1 ligand 1 | Authors: | Cheng, Y, Xiao, Y.B. | Deposit date: | 2023-07-22 | Release date: | 2024-01-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J.Med.Chem., 66, 2023
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4L1T
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