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2RNT
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BU of 2rnt by Molmil
THREE-DIMENSIONAL STRUCTURE OF RIBONUCLEASE T1 COMPLEXED WITH GUANYLYL-2(PRIME),5(PRIME)-GUANOSINE AT 1.8 ANGSTROMS RESOLUTION
Descriptor: CALCIUM ION, GUANYLYL-2',5'-PHOSPHOGUANOSINE, RIBONUCLEASE T1
Authors:Saenger, W, Koepke, J, Maslowska, M, Heinemann, U.
Deposit date:1988-07-06
Release date:1989-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of ribonuclease T1 complexed with guanylyl-2',5'-guanosine at 1.8 A resolution.
J.Mol.Biol., 206, 1989
1LRA
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BU of 1lra by Molmil
CRYSTALLOGRAPHIC STUDY OF GLU 58 ALA RNASE T1(ASTERISK)2'-GUANOSINE MONOPHOSPHATE AT 1.9 ANGSTROMS RESOLUTION
Descriptor: GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1, SODIUM ION
Authors:Pletinckx, J, Steyaert, J, Choe, H.-W, Heinemann, U, Wyns, L.
Deposit date:1993-10-01
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic study of Glu58Ala RNase T1 x 2'-guanosine monophosphate at 1.9-A resolution.
Biochemistry, 33, 1994
4M0Z
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BU of 4m0z by Molmil
Crystal structure of ITK in complex with compound 5 {4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide}
Descriptor: 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK
Authors:Han, S, Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
5FXQ
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BU of 5fxq by Molmil
IGFR-1R complex with a pyrimidine inhibitor.
Descriptor: 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
Authors:Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
4M12
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BU of 4m12 by Molmil
Crystal structure of ITK in complex with compound 7 [4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide]
Descriptor: 4-(carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1H-pyrazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK
Authors:Han, S, Caspers, N.L.
Deposit date:2013-08-02
Release date:2014-04-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Biochem.J., 460, 2014
5FXR
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BU of 5fxr by Molmil
IGFR-1R complex with a pyrimidine inhibitor.
Descriptor: 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
Authors:Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
2VSP
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BU of 2vsp by Molmil
Crystal structure of the fourth PDZ domain of PDZ domain-containing protein 1
Descriptor: PDZ DOMAIN-CONTAINING PROTEIN 1
Authors:Yue, W.W, Shafqat, N, Pilka, E.S, Johansson, C, Murray, J.W, Elkins, J, Roos, A, Cooper, C, Phillips, C, Salah, E, von Delft, F, Doyle, D, Edwards, A, Wikstrom, M, Arrowsmith, C, Bountra, C, Oppermann, U.
Deposit date:2008-04-28
Release date:2009-03-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of the Fourth Pdz Domain of Pdz Domain-Containing Protein 1
To be Published
2W7R
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BU of 2w7r by Molmil
Structure of the PDZ domain of Human Microtubule associated serine- threonine kinase 4
Descriptor: MICROTUBULE-ASSOCIATED SERINE/THREONINE-PROTEIN KINASE 4, PHOSPHATE ION
Authors:Muniz, J.R.C, Elkins, J, Wang, J, Savitzky, P, Roos, A, Salah, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S.
Deposit date:2008-12-24
Release date:2009-05-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unusual Binding Interactions in Pdz Domain Crystal Structures Help Explain Binding Mechanisms.
Protein Sci., 19, 2010
5FLF
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BU of 5flf by Molmil
DISEASE LINKED MUTATION IN FGFR
Descriptor: ACETATE ION, CHLORIDE ION, FIBROBLAST GROWTH FACTOR RECEPTOR 1, ...
Authors:Thiyagarajan, N, Bunney, T.D, Katan, M.
Deposit date:2015-10-26
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Landscape of Activating Cancer Mutations in Fgfr Kinases and Their Differential Responses to Inhibitors in Clinical Use.
Oncotarget, 7, 2016
7PB2
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BU of 7pb2 by Molmil
Crystal structure of JDI TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK)
Descriptor: Beta-2-microglobulin, KRAS G12D peptide (VVVGADGVGK), MHC class I antigen, ...
Authors:Coles, C.H, Karuppiah, V, Robinson, R.A.
Deposit date:2021-07-30
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nat Commun, 13, 2022
7OW5
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BU of 7ow5 by Molmil
Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVVGAGGVGK)
Descriptor: Beta-2-microglobulin, KRAS peptide (VVVGAGGVGK), MHC class I antigen, ...
Authors:Karuppiah, V, Robinson, R.A.
Deposit date:2021-06-16
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nat Commun, 13, 2022
7OW6
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BU of 7ow6 by Molmil
Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS G12D peptide (VVVGADGVGK)
Descriptor: Beta-2-microglobulin, KRAS G12D peptide (VVVGADGVGK), MHC class I antigen, ...
Authors:Karuppiah, V, Robinson, R.A.
Deposit date:2021-06-16
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nat Commun, 13, 2022
7OW3
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BU of 7ow3 by Molmil
Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVVGAGGVGK)
Descriptor: Beta-2-microglobulin, KRAS peptide (VVVGAGGVGK), MHC class I antigen
Authors:Coles, C.H, Karuppiah, V, Robinson, R.A.
Deposit date:2021-06-16
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nat Commun, 13, 2022
7OW4
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BU of 7ow4 by Molmil
Crystal structure of HLA-A*11:01 in complex with KRAS G12D peptide (VVVGADGVGK)
Descriptor: Beta-2-microglobulin, KRAS G12D peptide (VVVGADGVGK), MHC class I antigen, ...
Authors:Coles, C.H, Karuppiah, V, Robinson, R.A.
Deposit date:2021-06-16
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nat Commun, 13, 2022
8ROY
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BU of 8roy by Molmil
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24
Descriptor: 1-[5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-3-methyl-furan-2-yl]carbonyl-~{N}-methyl-piperidine-4-carboxamide, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ...
Authors:Shilliday, F, Lucas, S.C.C, Richter, M, Michaelides, I.N, Fusani, L.
Deposit date:2024-01-12
Release date:2024-04-03
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
J.Med.Chem., 67, 2024
8ROX
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BU of 8rox by Molmil
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 12
Descriptor: 5-[[3,4-bis(chloranyl)-1~{H}-indol-7-yl]sulfamoyl]-~{N},~{N},3-trimethyl-furan-2-carboxamide;ethane, DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, ...
Authors:Shilliday, F, Lucas, S.C.C, Richter, M, Michaelides, I.N, Fusani, L.
Deposit date:2024-01-12
Release date:2024-04-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
J.Med.Chem., 67, 2024
8OWG
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BU of 8owg by Molmil
Crystal structure of D1228V c-MET bound by compound 2
Descriptor: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2023-04-27
Release date:2023-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
8OVZ
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BU of 8ovz by Molmil
Crystal structure of D1228V c-MET bound by compound 16
Descriptor: 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, Hepatocyte growth factor receptor, IODIDE ION
Authors:Collie, G.W.
Deposit date:2023-04-26
Release date:2023-07-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
8OUU
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BU of 8ouu by Molmil
Crystal structure of D1228V c-MET bound by compound 29
Descriptor: 1,2-ETHANEDIOL, 5-(3-ethynyl-5-fluoranyl-1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, FORMIC ACID, ...
Authors:Collie, G.W.
Deposit date:2023-04-24
Release date:2023-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
8OUV
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BU of 8ouv by Molmil
Crystal structure of D1228V c-MET bound by compound 15
Descriptor: 5-(1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, CHLORIDE ION, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2023-04-24
Release date:2023-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.783 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
8OV7
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BU of 8ov7 by Molmil
Crystal structure of D1228V c-MET bound by compound 10
Descriptor: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-[3-(1H-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2023-04-25
Release date:2023-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
8OW3
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BU of 8ow3 by Molmil
Crystal structure of wild-type c-MET bound by compound 2
Descriptor: 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2023-04-26
Release date:2023-07-05
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
J.Med.Chem., 66, 2023
5FXS
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BU of 5fxs by Molmil
IGFR-1R complex with a pyrimidine inhibitor.
Descriptor: 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide, ACETATE ION, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
Authors:Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C.
Deposit date:2016-03-02
Release date:2016-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
7RRD
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BU of 7rrd by Molmil
IDO1 IN COMPLEX WITH COMPOUND S-1
Descriptor: 3-[4-(1H-benzimidazol-2-yl)phenyl]-N-(4-fluorophenyl)oxetane-3-carboxamide, Indoleamine 2,3-dioxygenase 1
Authors:Lesburg, C.A.
Deposit date:2021-08-09
Release date:2022-08-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Oxetane promise delivered: discovery of long acting IDO1 inhibitors suitable for Q3W oral or parenteral dosing
To Be Published
7RRC
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BU of 7rrc by Molmil
IDO1 IN COMPLEX WITH COMPOUND 14
Descriptor: Indoleamine 2,3-dioxygenase 1, N-(4-fluorophenyl)-3-{4-[4-(hydroxymethyl)-6-(trifluoromethyl)pyridin-3-yl]phenyl}oxetane-3-carboxamide
Authors:Lesburg, C.A.
Deposit date:2021-08-09
Release date:2022-03-16
Last modified:2022-05-11
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J.Med.Chem., 65, 2022

221716

數據於2024-06-26公開中

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