8ROY

Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to compound furan 24

This is a non-PDB format compatible entry.

Summary for 8ROY

• Entry DOI: 10.2210/pdb8roy/pdb
• EMDB information: 19407
• Descriptor: DDB1- and CUL4-associated factor 15, DNA damage-binding protein 1, DET1- and DDB1-associated protein 1, ... (4 entities in total)
• Functional Keywords: e3 ligase, complex, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 172538.38

Authors

Shilliday, F.,Lucas, S.C.C.,Richter, M.,Michaelides, I.N.,Fusani, L. (deposition date: 2024-01-12, release date: 2024-04-03, Last modification date: 2024-04-24)

• Primary citation: Lucas, S.C.C.,Ahmed, A.,Ashraf, S.N.,Argyrou, A.,Bauer, M.R.,De Donatis, G.M.,Demanze, S.,Eisele, F.,Fusani, L.,Hock, A.,Kadamur, G.,Li, S.,Macmillan-Jones, A.,Michaelides, I.N.,Phillips, C.,Rehnstrom, M.,Richter, M.,Rodrigo-Brenni, M.C.,Shilliday, F.,Wang, P.,Storer, R.I.; Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.; J.Med.Chem., 67:5538-5566, 2024; PubMed: 38513086; DOI: 10.1021/acs.jmedchem.3c02136

Experimental method

ELECTRON MICROSCOPY (3.1 Å)