5FXS

IGFR-1R complex with a pyrimidine inhibitor.

Summary for 5FXS

Entry DOI	10.2210/pdb5fxs/pdb
Related	5FXQ 5FXR
Descriptor	INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, ACETATE ION, 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	35851.46
Authors	Degorce, S.,Boyd, S.,Curwen, J.,Ducray, R.,Halsall, C.,Jones, C.,Lach, F.,Lenz, E.,Pass, M.,Pass, S.,Trigwell, C.,Norman, R.,Phillips, C. (deposition date: 2016-03-02, release date: 2016-10-19, Last modification date: 2018-07-11)
Primary citation	Degorce, S.L.,Boyd, S.,Curwen, J.O.,Ducray, R.,Halsall, C.T.,Jones, C.D.,Lach, F.,Lenz, E.M.,Pass, M.,Pass, S.,Trigwell, C. Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R). J. Med. Chem., 59:4859-4866, 2016 Cited by PubMed: 27078757 DOI: 10.1021/acs.jmedchem.6b00203 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation