5FXS
IGFR-1R complex with a pyrimidine inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | polymer | 308 | 35165.3 | 1 | UniProt (P08069) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | INSULIN-LIKE GROWTH FACTOR I RECEPTOR, IGF-I RECEPTOR, IGFR-1R |
| 2 | B, C, D (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 3 | E (A) | 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide | non-polymer | 508.0 | 1 | Chemie (OZN) | |||
| 4 | F (A) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A: 980 - 1286 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Ser 979 | - | expression tag |
| Ala 1159 | Asp 1159 | conflict |
| Glu 1211 | Gln 1211 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35165.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 685.1 | |
| All* | Total formula weight | 35850.5 |
