5FXS

IGFR-1R complex with a pyrimidine inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 2287

Chain	Residue
A	ARG996
A	LEU1076

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT A 2288

Chain	Residue
A	ARG1084

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 2289

Chain	Residue
A	ARG1084
A	HOH2124
A	OZN2290

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE OZN A 2290

Chain	Residue
A	VAL1013
A	ALA1031
A	MET1079
A	GLU1080
A	MET1082
A	GLY1085
A	ASP1153
A	MET1156
A	HOH2125
A	ACT2289
A	PHE981
A	SER982
A	LEU1005

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK

Chain	Residue	Details
A	LEU1005-LYS1033

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV

Chain	Residue	Details
A	PHE1131-VAL1143

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP1135

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU1005

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS1033

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:7541045

Chain	Residue	Details
A	TYR980

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site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11694888, ECO:0000269|PubMed:18501599, ECO:0000269|PubMed:19041240

Chain	Residue	Details
A	TYR1161
A	TYR1165
A	TYR1166

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000250|UniProtKB:Q60751

Chain	Residue	Details
A	SER1278

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60751

Chain	Residue	Details
A	SER1282

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site_id	SWS_FT_FI8
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21994939

Chain	Residue	Details
A	LYS1168
A	LYS1171

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