7MXP
 
 | | Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)][beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Reddem, E.R, Casner, R.G, Shapiro, L. | | Deposit date: | 2021-05-19 | | Release date: | 2022-05-25 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.46 Å) | | Cite: | Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS-CoV-2.
Aiche J, 67, 2021
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5K6Z
 | | Sidekick chimera containing sidekick-2 immunoglobulin domains 1-2 and sidekick-1 immunoglobulin domains 3-4 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Goodman, K.M, Mannepalli, S, Honig, B, Shapiro, L. | | Deposit date: | 2016-05-25 | | Release date: | 2016-09-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Elife, 5, 2016
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5K6W
 | | Sidekick-1 immunoglobulin domains 1-5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Goodman, K.M, Mannepalli, S, Honig, B, Shapiro, L. | | Deposit date: | 2016-05-25 | | Release date: | 2016-09-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
Elife, 5, 2016
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1L3W
 | | C-cadherin Ectodomain | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Boggon, T.J, Murray, J, Chappuis-Flament, S, Wong, E, Gumbiner, B.M, Shapiro, L. | | Deposit date: | 2002-03-01 | | Release date: | 2002-04-26 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | C-cadherin ectodomain structure and implications for cell adhesion mechanisms
Science, 296, 2002
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1XXL
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1JVK
 | | THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR | | Descriptor: | IMMUNOGLOBULIN LAMBDA LIGHT CHAIN | | Authors: | Bourne, P.C, Ramsland, P.A, Shan, L, Fan, Z.-C, DeWitt, C.R, Shultz, B.B, Terzyan, S.S, Edmundson, A.B. | | Deposit date: | 2001-08-30 | | Release date: | 2002-05-03 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties.
Acta Crystallogr.,Sect.D, 58, 2002
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2AWD
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1M0T
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2F3W
 | | solution structure of 1-110 fragment of staphylococcal nuclease in 2M TMAO | | Descriptor: | Thermonuclease | | Authors: | Liu, D, Xie, T, Feng, Y, Shan, L, Ye, K, Wang, J. | | Deposit date: | 2005-11-22 | | Release date: | 2006-12-05 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
Biophys.J., 92, 2007
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2ESR
 | | conserved hypothetical protein- streptococcus pyogenes | | Descriptor: | Methyltransferase, alpha-D-glucopyranose | | Authors: | Jiang, J, Min, T, Gorman, J, Shapiro, L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2005-10-26 | | Release date: | 2006-02-07 | | Last modified: | 2021-02-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of hypothetical protein of Streptococcus Pygenes
To be Published
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1DQL
 | | CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI-PEPTIDE ANTIBODY | | Descriptor: | IGM MEZ IMMUNOGLOBULIN | | Authors: | Ramsland, P.A, Shan, L, Moomaw, C.R, Slaughter, C.A, Guddat, L.W, Edmundson, A.B. | | Deposit date: | 2000-01-04 | | Release date: | 2000-10-04 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands.
Mol.Immunol., 37, 2000
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9IY0
 | | anti-HEV mAb 8H3 | | Descriptor: | Heavy chain of 8H3 Fab, Light chain of 8H3 Fab, MAGNESIUM ION | | Authors: | Minghua, Z, Lizhi, Z, Yang, H, Ying, G, Shaowei, L. | | Deposit date: | 2024-07-29 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction
To Be Published
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8TNL
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8TOA
 | | CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H7.HK2 Neutralizing Antibody Heavy Chain, H7.HK2 Neutralizing Antibody Light Chain, ... | | Authors: | Morano, N.C, Becker, J.E, Wu, X, Shapiro, L. | | Deposit date: | 2023-08-03 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | CryoEM structure of H7 hemagglutinin from A/Shanghai2/2013 H7N9 in complex with a human neutralizing antibody H7.HK1
To Be Published
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8TJR
 | | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody HERH-a.01 Heavy Chain, ... | | Authors: | Morano, N.C, Hoyt, F, Hansen, B, Fischer, E, Shapiro, L. | | Deposit date: | 2023-07-24 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB
To Be Published
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8TJS
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8DUL
 | | Cryo-EM Structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab SKT05 heavy chain, ... | | Authors: | Cerutti, G, Verardi, R, Roederer, M, Shapiro, L. | | Deposit date: | 2022-07-27 | | Release date: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
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8DUN
 | | Cryo-EM Structure of Antibody SKW11 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody SKW11 heavy chain, ... | | Authors: | Cerutti, G, Verardi, R, Roederer, M, Shapiro, L. | | Deposit date: | 2022-07-27 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (5.84 Å) | | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell, 186, 2023
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8TXU
 | | Fab 3864-10 in complex with influenza HA H3-SING16 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 3864-10 Heavy Chain, Fab 3864-10 Light Chain, ... | | Authors: | Morano, N.C, Shapiro, L. | | Deposit date: | 2023-08-24 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Fab 3864-6 in complex with influenza HA H3-VIC11
To Be Published
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8TX3
 | | Fab 3864-6 in complex with influenza HA H3-VIC11 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 3864-6 Heavy Chain, Fab 3864-6 Light Chain, ... | | Authors: | Morano, N.C, Shapiro, L. | | Deposit date: | 2023-08-22 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Fab 3864-6 in complex with influenza HA H3-VIC11
To Be Published
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6WU5
 | | Human Calcium and Integrin Binding Protein 3 | | Descriptor: | CALCIUM ION, CHLORIDE ION, Calcium and integrin-binding family member 3, ... | | Authors: | Dionne, G, Shapiro, L. | | Deposit date: | 2020-05-04 | | Release date: | 2021-06-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Neuron, 109, 2021
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8EYZ
 | | Engineered glutamine binding protein bound to GLN and a cobaloxime ligand | | Descriptor: | AZIDOBIS (DIMETHYLGLYOXIMATO) PYRIDINECOBALT, Amino acid ABC transporter substrate-binding protein, GLUTAMINE, ... | | Authors: | Bridwell-Rabb, J, Boggs, D.G, Olshansky, L, Fatima, S, Thompson, P. | | Deposit date: | 2022-10-29 | | Release date: | 2022-11-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Engineering a Conformationally Switchable Artificial Metalloprotein.
J.Am.Chem.Soc., 144, 2022
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8EM4
 | | Cryo-EM structure of LRP2 at pH 7.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Beenken, A, Cerutti, G, Brasch, J, Fitzpatrick, A.W, Barasch, J, Shapiro, L. | | Deposit date: | 2022-09-26 | | Release date: | 2023-02-08 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Structures of LRP2 reveal a molecular machine for endocytosis.
Cell, 186, 2023
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8EM7
 | | Cryo-EM structure of LRP2 at pH 5.2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Beenken, A, Cerutti, G, Fitzpatrick, A.W, Barasch, J, Shapiro, L. | | Deposit date: | 2022-09-27 | | Release date: | 2023-02-08 | | Last modified: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Structures of LRP2 reveal a molecular machine for endocytosis.
Cell, 186, 2023
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6XSK
 | | Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 789-203-3C12 Fab Heavy Chain, ... | | Authors: | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | | Deposit date: | 2020-07-15 | | Release date: | 2021-07-21 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Immunity, 55, 2022
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