7MXP

Cryo-EM structure of NTD-directed neutralizing antibody LP5 Fab in complex with SARS-CoV-2 S2P spike

Summary for 7MXP

• Entry DOI: 10.2210/pdb7mxp/pdb
• EMDB information: 24075
• Descriptor: Spike glycoprotein, LP5 Fab Heavy Chain, LP5 Fab Light Chain, ... (7 entities in total)
• Functional Keywords: neturalsing antibody, fusion protein, spike glycoprotein, nrd, ntd-directed antibody, lp5, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 9
• Total formula weight: 513955.83

Authors

Reddem, E.R.,Casner, R.G.,Shapiro, L. (deposition date: 2021-05-19, release date: 2022-05-25, Last modification date: 2022-12-21)

• Primary citation: Madan, B.,Reddem, E.R.,Wang, P.,Casner, R.G.,Nair, M.S.,Huang, Y.,Fahad, A.S.,de Souza, M.O.,Banach, B.B.,Lopez Acevedo, S.N.,Pan, X.,Nimrania, R.,Teng, I.T.,Bahna, F.,Zhou, T.,Zhang, B.,Yin, M.T.,Ho, D.D.,Kwong, P.D.,Shapiro, L.,DeKosky, B.J.; Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS-CoV-2.; Aiche J, 67:e17440-e17440, 2021; PubMed: 34898670; DOI: 10.1002/aic.17440

Experimental method

ELECTRON MICROSCOPY (4.46 Å)