8AT6
 
 | | Cryo-EM structure of yeast Elp456 subcomplex | | Descriptor: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
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8ASW
 | | Cryo-EM structure of yeast Elp123 in complex with alanine tRNA | | Descriptor: | 5'-DEOXYADENOSINE, Alanine tRNA, Elongator complex protein 1, ... | | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | | Deposit date: | 2022-08-21 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
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8AVG
 | | Cryo-EM structure of mouse Elp123 with bound SAM | | Descriptor: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
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8ASV
 | | Cryo-EM structure of yeast Elongator complex | | Descriptor: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | | Deposit date: | 2022-08-21 | | Release date: | 2022-12-07 | | Last modified: | 2023-03-29 | | Method: | ELECTRON MICROSCOPY (4.35 Å) | | Cite: | Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
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4U6H
 | | Vaccinia L1/M12B9-Fab complex | | Descriptor: | Heavy chain of murine anti-vaccinia L1 IgG2a antibody M12B9, Light chain of murine anti-vaccinia L1 IgG2a antibody M12B9, Protein L1 | | Authors: | Matho, M.H, Schlossman, A, Zajonc, D.M. | | Deposit date: | 2014-07-29 | | Release date: | 2014-08-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in l1 protein.
J.Virol., 88, 2014
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8B5Y
 | | SHP2 in complex with allosteric imidazopyrazine inhibitor | | Descriptor: | (1~{S})-1'-[5-[2-(trifluoromethyl)pyridin-3-yl]sulfanyl-3~{H}-imidazo[4,5-b]pyrazin-2-yl]spiro[1,3-dihydroindene-2,4'-piperidine]-1-amine, FORMIC ACID, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Torrente, E, Petrocchi, A. | | Deposit date: | 2022-09-25 | | Release date: | 2023-01-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8CP6
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4JQH
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6C54
 | | Ebola nucleoprotein nucleocapsid-like assembly and the asymmetric unit | | Descriptor: | Nucleoprotein | | Authors: | Su, Z, Wu, C, Pintilie, G.D, Chiu, W, Amarasinghe, G.K, Leung, D.W. | | Deposit date: | 2018-01-13 | | Release date: | 2018-03-07 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.
Cell, 172, 2018
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8T6D
 | | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | | Descriptor: | (3R)-1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-3H-spiro[[1]benzofuran-2,4'-piperidin]-3-amine, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | | Deposit date: | 2023-06-15 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
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8T6G
 | | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | | Descriptor: | (1S)-1-{6-[(1S)-1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl]-3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-5-yl}ethan-1-ol, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Tang, Y, Nugyen, V, Wilbur, J.D. | | Deposit date: | 2023-06-15 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
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8T7Q
 | | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | | Descriptor: | 1-{3-[(2-chlorophenyl)sulfanyl]-1H-pyrazolo[3,4-b]pyrazin-6-yl}-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | | Deposit date: | 2023-06-21 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
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8T8Q
 | | Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors | | Descriptor: | 1-[(3P)-3-(3-chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Tang, Y, Nguyen, V, Wilbur, J.D. | | Deposit date: | 2023-06-23 | | Release date: | 2023-10-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
J.Med.Chem., 66, 2023
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6NBW
 | | Ternary Complex of Beta/Gamma-Actin with Profilin and AnCoA-NAA80 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | | Deposit date: | 2018-12-10 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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6NBE
 | | Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | | Deposit date: | 2018-12-07 | | Release date: | 2020-04-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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1CLS
 | | CROSS-LINKED HUMAN HEMOGLOBIN DEOXY | | Descriptor: | HEMOGLOBIN, OXYGEN ATOM, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Ji, X, Fronticelli, C, Bucci, E, Gilliland, G.L. | | Deposit date: | 1995-08-29 | | Release date: | 1996-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacylhemoglobin.
Biochemistry, 35, 1996
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6NAS
 | | Ternary Complex of Ac-Alpha-Actin with Profilin and AcCoA-NAA80 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | | Deposit date: | 2018-12-06 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Mechanism of actin N-terminal acetylation.
Sci Adv, 6, 2020
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6RRE
 | | SidD, deAMPylase from Legionella pneumophila | | Descriptor: | Adenosine monophosphate-protein hydrolase SidD, MAGNESIUM ION | | Authors: | Tascon, I, Lucas, M, Rojas, A.L, Hierro, A. | | Deposit date: | 2019-05-17 | | Release date: | 2020-10-07 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (3.586 Å) | | Cite: | Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD.
Plos Pathog., 16, 2020
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6RP4
 | | CDT of SidD, deAMPylase from Legionella pneumophila | | Descriptor: | Adenosine monophosphate-protein hydrolase SidD, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Tascon, I, Lucas, M, Rojas, A.L, Hierro, A. | | Deposit date: | 2019-05-13 | | Release date: | 2020-10-07 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insight into the membrane targeting domain of the Legionella deAMPylase SidD.
Plos Pathog., 16, 2020
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5NWX
 | | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 | | Descriptor: | Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6 | | Authors: | Russo, L, Giller, K, Pfitzner, E, Griesinger, C, Becker, S. | | Deposit date: | 2017-05-08 | | Release date: | 2017-12-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6.
Sci Rep, 7, 2017
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5WJE
 | | Crystal structure of Naa80 bound to a bisubstrate analogue | | Descriptor: | Actin N-terminus peptide, CARBOXYMETHYL COENZYME *A, CG8481, ... | | Authors: | Goris, M, Magin, R.S, Marmorstein, R, Arnesen, T. | | Deposit date: | 2017-07-21 | | Release date: | 2018-03-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.765 Å) | | Cite: | Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5WJD
 | | Crystal structure of Naa80 bound to acetyl-CoA | | Descriptor: | ACETYL COENZYME *A, CG8481, isoform B, ... | | Authors: | Goris, M, Magin, R.S, Marmorstein, R, Arnesen, T. | | Deposit date: | 2017-07-21 | | Release date: | 2018-03-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7Q3B
 | | Crystal structure of human STING in complex with 3'3'-c-(2'F,2'dA-isonucA)MP | | Descriptor: | 3'3'-c-(2'F,2'dA-isonucA)MP, Stimulator of interferon genes protein | | Authors: | Smola, M, Klima, M, Boura, E. | | Deposit date: | 2021-10-27 | | Release date: | 2022-06-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.55733919 Å) | | Cite: | Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure, 30, 2022
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5IK4
 | | Laminin A2LG45 C-form, Apo. | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Briggs, D.C, Hohenester, E, Campbell, K.P. | | Deposit date: | 2016-03-03 | | Release date: | 2016-08-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
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5IK7
 | | Laminin A2LG45 I-form, Apo. | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Briggs, D.C, Hohenester, E, Campbell, K.P. | | Deposit date: | 2016-03-03 | | Release date: | 2016-08-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Nat.Chem.Biol., 12, 2016
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