5UA2
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![BU of 5ua2 by Molmil](/molmil-images/mine/5ua2) | Mycobacterium tuberculosis KstR in complex with a 26-bp DNA operator | Descriptor: | DNA (5'-D(P*AP*CP*TP*AP*TP*TP*AP*GP*AP*AP*CP*AP*CP*GP*TP*TP*CP*TP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*CP*TP*AP*GP*AP*AP*CP*GP*TP*GP*TP*TP*CP*TP*AP*AP*TP*AP*GP*T)-3'), HTH-type transcriptional repressor KstR, ... | Authors: | Ho, N.A.T, Dawes, S.S, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2016-12-18 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9002 Å) | Cite: | Crystal structure of KstR in complex with cognate DNA operator To Be Published
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5C1R
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![BU of 5c1r by Molmil](/molmil-images/mine/5c1r) | Stereoisomer of PRPP bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyl (AnPRT; trpD) | Descriptor: | 5-O-[(R)-hydroxy(phosphonooxy)phosphoryl]-1-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Evans, G.L, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-06-15 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Binding and mimicking of the phosphate-rich substrate, PRPP. To Be Published
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5C2L
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![BU of 5c2l by Molmil](/molmil-images/mine/5c2l) | |
5BO3
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![BU of 5bo3 by Molmil](/molmil-images/mine/5bo3) | |
5UA1
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![BU of 5ua1 by Molmil](/molmil-images/mine/5ua1) | Mycobacterium tuberculosis KstR in complex with a 18-bp DNA operator | Descriptor: | DNA (5'-D(*AP*CP*TP*AP*GP*AP*AP*CP*GP*TP*GP*TP*TP*CP*TP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*AP*GP*AP*AP*CP*AP*CP*GP*TP*TP*CP*TP*AP*GP*T)-3'), HTH-type transcriptional repressor KstR, ... | Authors: | Ho, N.A.T, Dawes, S.S, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2016-12-18 | Release date: | 2017-11-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of KstR in complex with cognate DNA operator To Be Published
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5CW8
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![BU of 5cw8 by Molmil](/molmil-images/mine/5cw8) | Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-4-cholesten-26-oyl-CoA | Descriptor: | HTH-type transcriptional repressor KstR, S-{1-[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,7-dihydroxy-6,6-dimethyl-3-oxido-8,12 -dioxo-2,4-dioxa-9,13-diaza-3lambda~5~-phosphapentadecan-15-yl} (2S,6R)-6-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta [a]phenanthren-17-yl]-2-methylheptanethioate (non-preferred name), TRIETHYLENE GLYCOL | Authors: | Ho, N.A.T, Dawes, S, Kendall, S, Casabon, I, Crowe, A.M, Baker, E.N, Eltis, L.D, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-07-27 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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5CXG
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![BU of 5cxg by Molmil](/molmil-images/mine/5cxg) | Crystal structure of Mycobacterium tuberculosis KstR in complex with PEG | Descriptor: | DI(HYDROXYETHYL)ETHER, HTH-type transcriptional repressor KstR, TRIETHYLENE GLYCOL | Authors: | Ho, N.A.T, Dawes, S, Kendall, S, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-07-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1001 Å) | Cite: | The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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5V00
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![BU of 5v00 by Molmil](/molmil-images/mine/5v00) | Structure of HutD from Pseudomonas fluorescens SBW25 (Formate condition) | Descriptor: | FORMIC ACID, GLYCEROL, Uncharacterized protein | Authors: | Liu, Y, Johnston, J.M, Gerth, M.L, Baker, E.N, Lott, J.S, Rainey, P.B. | Deposit date: | 2017-02-27 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas. Proteins, 85, 2017
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5CXI
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![BU of 5cxi by Molmil](/molmil-images/mine/5cxi) | Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA) | Descriptor: | 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA, HTH-type transcriptional repressor KstR | Authors: | Ho, N.A.T, Dawes, S, Kendall, S, Casabon, I, Crowe, A.M, Baker, E.N, Eltis, L.D, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-07-29 | Release date: | 2016-02-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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5CWA
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![BU of 5cwa by Molmil](/molmil-images/mine/5cwa) | Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound | Descriptor: | 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Anthranilate synthase component 1, GLYCEROL, ... | Authors: | Johnston, J.M, Bashiri, G, Evans, G.L, Lott, J.S, Baker, E.N. | Deposit date: | 2015-07-28 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallogr.,Sect.D, 71, 2015
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4WPY
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![BU of 4wpy by Molmil](/molmil-images/mine/4wpy) | Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-II) | Descriptor: | GLYCEROL, protein DL-Rv1738, trifluoroacetic acid | Authors: | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | Deposit date: | 2014-10-21 | Release date: | 2015-03-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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4WSP
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![BU of 4wsp by Molmil](/molmil-images/mine/4wsp) | Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-I) | Descriptor: | CHLORIDE ION, protein DL-Rv1738 | Authors: | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | Deposit date: | 2014-10-28 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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2M3O
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![BU of 2m3o by Molmil](/molmil-images/mine/2m3o) | Structure and dynamics of a human Nedd4 WW domain-ENaC complex | Descriptor: | Amiloride-sensitive sodium channel subunit alpha, E3 ubiquitin-protein ligase NEDD4 | Authors: | Bobby, R, Medini, K, Neudecker, P, Lee, V, MacDonald, F.J, Brimble, M.A, Lott, J, Dingley, A.J. | Deposit date: | 2013-01-23 | Release date: | 2013-08-28 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of human Nedd4-1 WW3 in complex with the alpha ENaC PY motif. Biochim.Biophys.Acta, 1834, 2013
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5ID2
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![BU of 5id2 by Molmil](/molmil-images/mine/5id2) | |
6OGD
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![BU of 6ogd by Molmil](/molmil-images/mine/6ogd) | Cryo-EM structure of YenTcA in its prepore state | Descriptor: | Chitinase 2, Toxin subunit YenA1, Toxin subunit YenA2 | Authors: | Piper, S.J, Brillault, L, Box, J.K, Landsberg, M.J. | Deposit date: | 2019-04-02 | Release date: | 2019-05-08 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin. Nat Commun, 10, 2019
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3KGF
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![BU of 3kgf by Molmil](/molmil-images/mine/3kgf) | The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan | Descriptor: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2009-10-29 | Release date: | 2010-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis J.Biol.Chem., 285, 2010
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6BP6
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![BU of 6bp6 by Molmil](/molmil-images/mine/6bp6) | |
4X1U
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![BU of 4x1u by Molmil](/molmil-images/mine/4x1u) | |
4X0X
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3NV8
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![BU of 3nv8 by Molmil](/molmil-images/mine/3nv8) | The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in complex with phosphoenol pyruvate and manganese (thesit-free) | Descriptor: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Parker, E.J, Jameson, G.B, Jiao, W, Hutton, R.H, Webby, C.J, Baker, E.N, Baker, H.M. | Deposit date: | 2010-07-08 | Release date: | 2010-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis J.Biol.Chem., 285, 2010
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