6QDM
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6QDK
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5EYM
| MEK1 IN COMPLEX WITH BI 847325 | Descriptor: | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1 | Authors: | Bader, G, Reiser, U, Zahn, S.K, Treu, M. | Deposit date: | 2015-11-25 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
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5EYK
| CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325 | Descriptor: | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, Aurora kinase B-A, Inner centromere protein A | Authors: | Bader, G, Zoephel, A. | Deposit date: | 2015-11-25 | Release date: | 2016-08-17 | Last modified: | 2016-10-19 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
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1ZFI
| Solution structure of the leech carboxypeptidase inhibitor | Descriptor: | Metallocarboxypeptidase inhibitor | Authors: | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | Deposit date: | 2005-04-20 | Release date: | 2005-09-13 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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5D4W
| Crystal structure of Hsp104 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Putative heat shock protein | Authors: | Heuck, A, Schitter-Sollner, S, Clausen, T. | Deposit date: | 2015-08-09 | Release date: | 2016-12-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural basis for the disaggregase activity and regulation of Hsp104. Elife, 5, 2016
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1ZFL
| Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor | Descriptor: | Metallocarboxypeptidase inhibitor | Authors: | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | Deposit date: | 2005-04-20 | Release date: | 2005-09-13 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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8ATX
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8ATU
| Cryo-EM structure of human BIRC6 | Descriptor: | Baculoviral IAP repeat-containing protein 6, ZINC ION | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | Deposit date: | 2022-08-24 | Release date: | 2023-02-15 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
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8AUW
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8AUK
| Cryo-EM structure of human BIRC6 in complex with HTRA2. | Descriptor: | Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... | Authors: | Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. | Deposit date: | 2022-08-25 | Release date: | 2023-02-15 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
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1DTV
| NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI) | Descriptor: | CARBOXYPEPTIDASE INHIBITOR | Authors: | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | Deposit date: | 2000-01-13 | Release date: | 2000-07-19 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. Nat.Struct.Biol., 7, 2000
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1DTD
| CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2) | Descriptor: | CARBOXYPEPTIDASE A2, GLUTAMIC ACID, METALLOCARBOXYPEPTIDASE INHIBITOR, ... | Authors: | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | Deposit date: | 2000-01-12 | Release date: | 2000-07-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. Nat.Struct.Biol., 7, 2000
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4KE6
| Crystal structure D196N mutant of Monoglyceride lipase from Bacillus sp. H257 in complex with 1-rac-lauroyl glycerol | Descriptor: | (2R)-2,3-dihydroxypropyl dodecanoate, (4S)-2-METHYL-2,4-PENTANEDIOL, Thermostable monoacylglycerol lipase | Authors: | Rengachari, S, Aschauer, P, Gruber, K, Dreveny, I, Oberer, M. | Deposit date: | 2013-04-25 | Release date: | 2013-09-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase. J.Biol.Chem., 288, 2013
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4KE7
| Crystal structure of Monoglyceride lipase from Bacillus sp. H257 in complex with an 1-myristoyl glycerol analogue | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Thermostable monoacylglycerol lipase, dodecyl hydrogen (S)-(3-azidopropyl)phosphonate | Authors: | Rengachari, S, Aschauer, P, Gruber, K, Dreveny, I, Oberer, M. | Deposit date: | 2013-04-25 | Release date: | 2013-09-18 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase. J.Biol.Chem., 288, 2013
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4KE9
| Crystal structure of Monoglyceride lipase from Bacillus sp. H257 in complex with an 1-stearyol glycerol analogue | Descriptor: | Thermostable monoacylglycerol lipase, hexadecyl hydrogen (R)-(3-azidopropyl)phosphonate | Authors: | Rengachari, S, Aschauer, P, Gruber, K, Dreveny, I, Oberer, M. | Deposit date: | 2013-04-25 | Release date: | 2013-09-18 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase. J.Biol.Chem., 288, 2013
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4KEA
| Crystal structure of D196N mutant of Monoglyceride lipase from Bacillus sp. H257 in space group P212121 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Thermostable monoacylglycerol lipase | Authors: | Rengachari, S, Aschauer, P, Gruber, K, Dreveny, I, Oberer, M. | Deposit date: | 2013-04-25 | Release date: | 2013-09-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase. J.Biol.Chem., 288, 2013
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6EIC
| Crystal structure of Rv0183, a Monoglyceride Lipase from Mycobacterium Tuberculosis | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Mycobacterium Tuberculosis Monoglyceride Lipase, NITRATE ION, ... | Authors: | Aschauer, P, Pavkov-Keller, T, Oberer, M. | Deposit date: | 2017-09-19 | Release date: | 2018-06-27 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition. Sci Rep, 8, 2018
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6FH1
| Protein arginine kinase McsB in the apo state | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, IMIDAZOLE, ... | Authors: | Suskiewicz, M.J, Heuck, A, Vu, L.D, Clausen, T. | Deposit date: | 2018-01-12 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nat.Chem.Biol., 15, 2019
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6FH4
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6FH2
| Protein arginine kinase McsB in the AMP-PN-bound state | Descriptor: | 1,2-ETHANEDIOL, AMP PHOSPHORAMIDATE, Protein-arginine kinase | Authors: | Suskiewicz, M.J, Heuck, A, Vu, L.D, Clausen, T. | Deposit date: | 2018-01-12 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nat.Chem.Biol., 15, 2019
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6FH3
| Protein arginine kinase McsB in the pArg-bound state | Descriptor: | 1,2-ETHANEDIOL, Protein-arginine kinase, phospho-arginine | Authors: | Suskiewicz, M.J, Heuck, A, Vu, L.D, Clausen, T. | Deposit date: | 2018-01-12 | Release date: | 2019-02-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nat.Chem.Biol., 15, 2019
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2R3Y
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2HSA
| Crystal structure of 12-oxophytodienoate reductase 3 (OPR3) from tomato | Descriptor: | 12-oxophytodienoate reductase 3, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ... | Authors: | Breithaupt, C, Clausen, T, Huber, R. | Deposit date: | 2006-07-21 | Release date: | 2006-09-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of 12-oxophytodienoate reductase 3 from tomato: Self-inhibition by dimerization. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2HS6
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