2AOX
| Histamine Methyltransferase (Primary Variant T105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine | Descriptor: | Histamine N-methyltransferase, TACRINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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1MOZ
| ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae | Descriptor: | ADP-ribosylation factor-like protein 1, GUANOSINE-5'-DIPHOSPHATE | Authors: | Amor, J.C, Horton, J.R, Zhu, X, Wang, Y, Sullards, C, Ringe, D, Cheng, X, Kahn, R.A. | Deposit date: | 2002-09-10 | Release date: | 2002-10-09 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structures of Yeast ARF2 and ARL1:
DISTINCT ROLES FOR THE N TERMINUS IN THE STRUCTURE
AND FUNCTION OF ARF FAMILY GTPases J.Biol.Chem., 276, 2001
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2AOV
| Histamine Methyltransferase Complexed with the Antifolate Drug Metoprine | Descriptor: | 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE, 5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE-2,4-DIAMINE, Histamine N-methyltransferase | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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2AOU
| Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine | Descriptor: | 4-[(7-CHLOROQUINOLIN-4-YL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL, Histamine N-methyltransferase | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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2AOT
| Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine | Descriptor: | Histamine N-methyltransferase, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. | Deposit date: | 2005-08-14 | Release date: | 2005-09-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
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6WE9
| YTH domain of human YTHDC1 with 11mer ssDNA Containing N6mA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*CP*TP*G)-3'), GLYCEROL, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res., 48, 2020
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6WK2
| SETD3 mutant (N255V) in Complex with an Actin Peptide with His73 Replaced with Methionine | Descriptor: | 1,2-ETHANEDIOL, Actin, cytoplasmic 2, ... | Authors: | Dai, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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6WMI
| ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*CP*AP*TP*AP*AP*TP*AP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*TP*TP*AP*TP*GP*GP*GP*AP*TP*GP*TP*G)-3'), ... | Authors: | Ren, R, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-21 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol.Cell, 81, 2021
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6WK1
| SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Actin, ... | Authors: | Dai, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J.Biol.Chem., 295, 2020
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6WE8
| YTH domain of human YTHDC1 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res., 48, 2020
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6WEA
| YTH domain of human YTHDC1 with a 10mer Oligo Containing N6mA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*CP*GP*GP*(6MA)P*CP*TP*TP*C)-3'), SODIUM ION, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res., 48, 2020
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6X9I
| Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... | Authors: | Pathuri, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-06-02 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
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6X9K
| Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3685032A | Descriptor: | (2R)-2-{[6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-yl]sulfanyl}-2-phenylacetamide, 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), ... | Authors: | Pathuri, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-06-02 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
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6X9J
| Human DNMT1(729-1600) Bound to Zebularine-Containing 12mer dsDNA and Inhibitor GSK3830052 | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*GP*AP*GP*GP*CP*(5CM)P*GP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*G)-R(P*(PYO))-D(P*GP*GP*CP*CP*TP*C)-3'), ... | Authors: | Pathuri, S, Horton, J.R, Cheng, X. | Deposit date: | 2020-06-02 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer, 2, 2021
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1JQE
| Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine | Descriptor: | Histamine N-Methyltransferase, QUINACRINE, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Zhang, X, Cheng, X. | Deposit date: | 2001-08-06 | Release date: | 2002-08-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure, 9, 2001
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1PEG
| Structural basis for the product specificity of histone lysine methyltransferases | Descriptor: | Histone H3, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | Authors: | Zhang, X, Yang, Z, Khan, S.I, Horton, J.R, Tamaru, H, Selker, E.U, Cheng, X. | Deposit date: | 2003-05-21 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural basis for the product specificity of histone lysine methyltransferases Mol.Cell, 12, 2003
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1JQD
| Crystal Structure Analysis of Human Histamine Methyltransferase (Thr105 Polymorphic Variant) Complexed with AdoHcy and Histamine | Descriptor: | HISTAMINE, Histamine N-Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Horton, J.R, Sawada, K, Nishibori, M, Zhang, X, Cheng, X. | Deposit date: | 2001-08-06 | Release date: | 2002-08-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure, 9, 2001
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1ORI
| Structure of the predominant protein arginine methyltransferase PRMT1 | Descriptor: | Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN LIGAND | Authors: | Zhang, X, Cheng, X. | Deposit date: | 2003-03-13 | Release date: | 2003-05-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of its Binding to Substrate Peptides Structure, 11, 2003
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1ML9
| Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase | Descriptor: | Histone H3 methyltransferase DIM-5, UNKNOWN, ZINC ION | Authors: | Zhang, X, Tamaru, H, Khan, S.I, Horton, J.R, Keefe, L.J, Selker, E.U, Cheng, X. | Deposit date: | 2002-08-30 | Release date: | 2002-10-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structure of the Neurospora SET domain protein DIM-5,
a histone H3 lysine methyltransferase Cell(Cambridge,Mass.), 111, 2002
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1OR8
| Structure of the Predominant protein arginine methyltransferase PRMT1 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhang, X, Cheng, X. | Deposit date: | 2003-03-12 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure, 11, 2003
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1KHC
| Crystal Structure of the PWWP Domain of Mammalian DNA Methyltransferase Dnmt3b | Descriptor: | DNA cytosine-5 methyltransferase 3B2, UNKNOWN ATOM OR ION | Authors: | Qiu, C, Sawada, K, Zhang, X, Cheng, X. | Deposit date: | 2001-11-29 | Release date: | 2002-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat.Struct.Biol., 9, 2002
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1Q0T
| Ternary Structure of T4DAM with AdoHcy and DNA | Descriptor: | 5'-D(*AP*CP*AP*GP*GP*AP*TP*CP*CP*TP*GP*T)-3', DNA adenine methylase, IODIDE ION, ... | Authors: | Yang, Z, Horton, J.R, Zhou, L, Zhang, X.J, Dong, A, Zhang, X, Schlagman, S.L, Kossykh, V, Hattman, S, Cheng, X. | Deposit date: | 2003-07-17 | Release date: | 2003-09-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the bacteriophage T4 DNA adenine methyltransferase Nat.Struct.Biol., 10, 2003
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1ORH
| Structure of the Predominant Protein Arginine Methyltransferase PRMT1 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhang, X, Cheng, X. | Deposit date: | 2003-03-13 | Release date: | 2003-08-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides Structure, 11, 2003
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1MR3
| Saccharomyces cerevisiae ADP-ribosylation Factor 2 (ScArf2) complexed with GDP-3'P at 1.6A resolution | Descriptor: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, ADP-ribosylation factor 2, ... | Authors: | Amor, J.-C, Horton, J.R, Zhu, X, Wang, Y, Sullards, C, Ringe, D, Cheng, X, Kahn, R.A. | Deposit date: | 2002-09-17 | Release date: | 2002-11-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases. J.Biol.Chem., 276, 2001
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1Q0S
| Binary Structure of T4DAM with AdoHcy | Descriptor: | DNA adenine methylase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Yang, Z, Horton, J.R, Zhou, L, Zhang, X.J, Dong, A, Zhang, X, Schlagman, S.L, Kossykh, V, Hattman, S, Cheng, X. | Deposit date: | 2003-07-17 | Release date: | 2003-09-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the bacteriophage T4 DNA adenine methyltransferase Nat.Struct.Biol., 10, 2003
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