8IRS
 
 | | Dopamine Receptor D2R-Gi-Rotigotine complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | Deposit date: | 2023-03-19 | | Release date: | 2023-06-07 | | Last modified: | 2023-11-08 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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8IRR
 | | Dopamine Receptor D1R-Gs-Rotigotine complex | | Descriptor: | CHOLESTEROL, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | Deposit date: | 2023-03-19 | | Release date: | 2023-06-21 | | Last modified: | 2023-11-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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8IRU
 | | Dopamine Receptor D4R-Gi-Rotigotine complex | | Descriptor: | CHOLESTEROL, D(4) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | | Deposit date: | 2023-03-19 | | Release date: | 2023-06-21 | | Last modified: | 2023-11-08 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
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7YDX
 | | Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | | Descriptor: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | | Authors: | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | | Deposit date: | 2022-07-04 | | Release date: | 2023-04-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.642 Å) | | Cite: | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.
Nat Commun, 13, 2022
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5WQO
 | | Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 in complex with NADP (condition I) | | Descriptor: | 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Probable dehydrogenase, ... | | Authors: | Li, S, Wang, Y, Bartlam, M. | | Deposit date: | 2016-11-27 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.
FEBS Lett., 591, 2017
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5WQM
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7VIB
 | | Crystal structure of human ACE2 and GX/P2V RBD | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein, ZINC ION | | Authors: | Guo, Y, Cao, W, Jia, N, Wang, W, Yuan, S, Wang, Y. | | Deposit date: | 2021-09-26 | | Release date: | 2022-10-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of human ACE2 and GX/P2V RBD
To Be Published
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5WQP
 | | Crystal structure of a carbonyl reductase from Pseudomonas aeruginosa PAO1 in complex with NADP (condition II) | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NICOTINAMIDE, PHOSPHATE ION, ... | | Authors: | Li, S, Wang, Y, Bartlam, M. | | Deposit date: | 2016-11-27 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure and characterization of a NAD(P)H-dependent carbonyl reductase from Pseudomonas aeruginosa PAO1.
FEBS Lett., 591, 2017
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7Y5X
 | | CryoEM structure of PS2-containing gamma-secretase treated with MRK-560 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-17 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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7Y5T
 | | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-17 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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7Y5Z
 | | CryoEM structure of human PS2-containing gamma-secretase | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2022-06-18 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
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7D73
 | | Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (State I) | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, GUANOSINE-5'-TRIPHOSPHATE, Mannose-1-phosphate guanyltransferase alpha, ... | | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | | Deposit date: | 2020-10-02 | | Release date: | 2021-05-05 | | Last modified: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
Nat.Struct.Mol.Biol., 28, 2021
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7D72
 | | Cryo-EM structures of human GMPPA/GMPPB complex bound to GDP-Mannose | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, MAGNESIUM ION, Mannose-1-phosphate guanyltransferase alpha, ... | | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, Cai, X, Mo, X, Gao, N, Jia, D. | | Deposit date: | 2020-10-02 | | Release date: | 2021-05-05 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
Nat.Struct.Mol.Biol., 28, 2021
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7D74
 | | Cryo-EM structure of GMPPA/GMPPB complex bound to GTP (state II) | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Mannose-1-phosphate guanyltransferase alpha, Mannose-1-phosphate guanyltransferase beta | | Authors: | Zheng, L, Liu, Z, Wang, Y, Yang, F, Wang, J, Qing, J, cai, X, Mo, X, Gao, N, Jia, D. | | Deposit date: | 2020-10-02 | | Release date: | 2021-05-19 | | Last modified: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.
Nat.Struct.Mol.Biol., 28, 2021
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6GT3
 | | Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... | | Authors: | Borodovsky, A, Wang, Y, Deng, N, Ye, M, Stephen, T.L, Goodwin, K, Goodwin, R, Strittmatter, N, Shaw, J, Sachsenmeier, K, Clarke, J.D, Hay, C, Reimer, C, Andrews, S.P, Brown, G.A, Congreve, M, Cheng, R.K.Y, Dore, A.S, Mason, J.S, Marshall, F.H, Weir, M.P, Lyne, P, Woessner, R. | | Deposit date: | 2018-06-15 | | Release date: | 2019-06-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
J Immunother Cancer, 2020
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6K6I
 | | The crystal structure of light-driven cyanobacterial chloride importer from Mastigocladopsis repens | | Descriptor: | CHLORIDE ION, Cyanobacterial chloride importer, OLEIC ACID, ... | | Authors: | Yun, J.H, Park, J.H, Jin, Z, Ohki, M, Wang, Y, Lupala, C.S, Kim, M, Liu, H, Park, S.Y, Lee, W. | | Deposit date: | 2019-06-03 | | Release date: | 2020-06-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The crystal structure of light-driven cyanobacterial chloride importer from Mastigocladopsis repens
To Be Published
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6K6K
 | | The crystal structure of light-driven cyanobacterial chloride importer (N63A/P118A) Mastigocladopsis repens | | Descriptor: | CHLORIDE ION, Cyanobacterial chloride importer, OLEIC ACID, ... | | Authors: | Yun, J.H, Park, J.H, Jin, Z, Ohki, M, Wang, Y, Lupala, C.S, Kim, M, Liu, H, Park, S.Y, Lee, W. | | Deposit date: | 2019-06-03 | | Release date: | 2020-06-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | The crystal structure of light-driven cyanobacterial chloride importer (N63A/P118A) Mastigocladopsis repens
To Be Published
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8K5A
 | | The cryo-EM map of open TIEA-TIC complex | | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | | Deposit date: | 2023-07-21 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | TIEA inhibits sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error
To Be Published
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8K58
 | | The cryo-EM map of close TIEA-TIC complex | | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | | Deposit date: | 2023-07-21 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | TIEA inhibits Sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error
To Be Published
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6K6J
 | | The crystal structure of light-driven cyanobacterial chloride importer from Mastigocladopsis repens with Bromide ion | | Descriptor: | BROMIDE ION, Cyanobacterial chloride importer, OLEIC ACID, ... | | Authors: | Yun, J.H, Park, J.H, Jin, Z, Ohki, M, Wang, Y, Lupala, C.S, Kim, M, Liu, H, Park, S.Y, Lee, W. | | Deposit date: | 2019-06-03 | | Release date: | 2020-06-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of light-driven cyanobacterial chloride importer from Mastigocladopsis repens with Bromide ion
To Be Published
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7XZ4
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7V5K
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1)
to be published
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7V5J
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2)
to be published
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7V6N
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | | Descriptor: | 111 H, 111 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-20 | | Release date: | 2022-09-14 | | Method: | ELECTRON MICROSCOPY (3.99 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1
to be published
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7V6O
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | | Descriptor: | 111 H, 111 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-20 | | Release date: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (4.56 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2)
to be published
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