7JKW
| Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with ZN1-99 | Descriptor: | Bromodomain-containing protein 4, N-(6-{5-[(azetidin-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridin-3-yl}-1-[1,1-di(pyridin-2-yl)ethyl]-1H-indol-4-yl)ethanesulfonamide | Authors: | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | Deposit date: | 2020-07-29 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63, 2020
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7JKX
| Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-6 | Descriptor: | Bromodomain-containing protein 4, N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-[1-methyl-5-(methylamino)-6-oxo-1,6-dihydropyridin-3-yl]-1H-indol-4-yl}ethanesulfonamide | Authors: | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | Deposit date: | 2020-07-29 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-6 To Be Published
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7KYQ
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7KYS
| Crystal structure of human BCCIP beta (Native2) | Descriptor: | 1,2-ETHANEDIOL, BRCA2 and CDKN1A-interacting protein, DI(HYDROXYETHYL)ETHER | Authors: | Choi, W.S, Liu, B, Shen, Z, Yang, W. | Deposit date: | 2020-12-08 | Release date: | 2021-06-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of human BCCIP and implications for binding and modification of partner proteins. Protein Sci., 30, 2021
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7JKZ
| Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126 | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... | Authors: | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | Deposit date: | 2020-07-29 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63, 2020
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7JKY
| Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-126 | Descriptor: | Bromodomain-containing protein 4, N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide, SODIUM ION | Authors: | Ratia, K.M, Xiong, R, Li, Y, Shen, Z, Zhao, J, Huang, F, Dubrovyskyii, O, Thatcher, G.R. | Deposit date: | 2020-07-29 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J.Med.Chem., 63, 2020
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3QPS
| Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | Descriptor: | CHOLIC ACID, CmeR | Authors: | Lei, H.T, Routh, M.D, Shen, Z, Su, C.C, Zhang, Q, Yu, E.W. | Deposit date: | 2011-02-14 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni. Protein Sci., 20, 2011
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3QQA
| Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | Descriptor: | CmeR, TAUROCHOLIC ACID | Authors: | Lei, H.T, Routh, M.D, Shen, Z, Su, C.-C, Zhang, Q, Yu, E.W. | Deposit date: | 2011-02-15 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni. Protein Sci., 20, 2011
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7E9V
| The Crystal Structure of human UMP-CMP kinase from Biortus. | Descriptor: | SULFATE ION, UMP-CMP kinase | Authors: | Wang, F, Lin, D, Wang, R, Wei, X, Shen, Z, Wang, M. | Deposit date: | 2021-03-05 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of human UMP-CMP kinase from Biortus. To Be Published
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8SXX
| E. coli dodecamer SIR2 | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-24 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SUB
| E. coli SIR2-HerA complex (dodecamer SIR2 pentamer HerA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-11 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SU9
| E. coli SIR2-HerA complex (hexamer HerA bound with dodecamer Sir2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-11 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SUW
| E. coli SIR2-HerA complex (dodecamer SIR2 bound 4 protomers of HerA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-13 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8FEX
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8FFI
| Structure of tetramerized MapSPARTA upon guide RNA-mediated target DNA binding | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2022-12-08 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8UAE
| E. coli Sir2_HerA complex (12:6) with ATPgamaS | Descriptor: | MAGNESIUM ION, Nucleoside triphosphate hydrolase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-09-20 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8UAF
| E. coli Sir2_HerA complex (12:6) bound with NAD+ | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-09-20 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SP3
| Asymmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-01 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8SPO
| Tetramerized activation of MapSPARTA bound with NAD+ | Descriptor: | MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain-containing protein, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-03 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8SP0
| Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-01 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8SQU
| Monomeric MapSPARTA bound with guide RNA and target DNA hybrid | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-04 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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6RQW
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6RQU
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6RQQ
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6RQN
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