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7MTY
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BU of 7mty by Molmil
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988569
Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2021-05-13
Release date:2022-05-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur.J.Med.Chem., 247, 2023
6VLL
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BU of 6vll by Molmil
The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986213
Descriptor: MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W.
Deposit date:2020-01-24
Release date:2021-02-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986213
To Be Published
8EDZ
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BU of 8edz by Molmil
The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319
Descriptor: Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ...
Authors:Cuypers, M.G, Slavish, J.P, Jayaraman, S, Rankovic, Z, White, S.W.
Deposit date:2022-09-06
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319
To Be Published
8DQS
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BU of 8dqs by Molmil
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023032
Descriptor: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[4-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2022-07-19
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023032
To Be Published
8E1Q
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BU of 8e1q by Molmil
The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044
Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2022-08-11
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044
To Be Published
8E21
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BU of 8e21 by Molmil
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034
Descriptor: 5-hydroxy-6-oxo-N-[2-(pyridin-4-yl)ethyl]-2-{[2-(trifluoromethyl)phenyl]methyl}-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2022-08-12
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034
To Be Published
8DVO
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BU of 8dvo by Molmil
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044
Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2022-07-29
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044
To Be Published
7K77
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BU of 7k77 by Molmil
The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ001008025
Descriptor: 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-[2-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W.
Deposit date:2020-09-22
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ001008025
To Be Published
7KNR
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BU of 7knr by Molmil
The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558
Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W.
Deposit date:2020-11-05
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988558
To Be Published
7KOP
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BU of 7kop by Molmil
The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539
Descriptor: 2-(2-fluorophenyl)-5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Seetharaman, J, White, S.W.
Deposit date:2020-11-09
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The crystal structure of the 2009/H1N1/California PA endonuclease I38T mutant in complex with SJ000988539
To Be Published
7KNY
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BU of 7kny by Molmil
The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528
Descriptor: 2-(2-fluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Jayaraman, S, White, S.W.
Deposit date:2020-11-06
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/California) in complex with SJ000988528
To Be Published
7LP7
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BU of 7lp7 by Molmil
The crystal structure of the wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476
Descriptor: (phenylmethyl) (2~{S})-2-[5-oxidanyl-6-oxidanylidene-4-(2-pyridin-4-ylethylcarbamoyl)-1~{H}-pyrimidin-2-yl]pyrrolidine-1-carboxylate, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W.
Deposit date:2021-02-11
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of the wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476
To Be Published
7LP8
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BU of 7lp8 by Molmil
The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476
Descriptor: (phenylmethyl) (2~{S})-2-[5-oxidanyl-6-oxidanylidene-4-(2-pyridin-4-ylethylcarbamoyl)-1~{H}-pyrimidin-2-yl]pyrrolidine-1-carboxylate, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W.
Deposit date:2021-02-11
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000983476
To Be Published
7ML8
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BU of 7ml8 by Molmil
The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ001023038
Descriptor: 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-2-phenyl-1,6-dihydropyrimidine-4-carboxamide, GLUTAMIC ACID, Hexa Vinylpyrrolidone K15, ...
Authors:Cuypers, M.G, Slavish, P.J, Yun, M.K, Dubois, R, Rankovic, Z, White, S.W.
Deposit date:2021-04-27
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with St Jude compound AC067-19
To Be Published
7MX0
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BU of 7mx0 by Molmil
The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988558
Descriptor: 2-(2,6-difluorophenyl)-5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-oxo-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ...
Authors:Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W.
Deposit date:2021-05-17
Release date:2022-05-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988558
To Be Published
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數據於2024-06-19公開中

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