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6E7X
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BU of 6e7x by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-97
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Regan, M.C, Furukawa, H.
Deposit date:2018-07-27
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10, 2019
3QEL
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BU of 3qel by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ...
Authors:Karakas, E, Simorowski, N, Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
3QEK
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BU of 3qek by Molmil
Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NMDA glutamate receptor subunit, POTASSIUM ION, ...
Authors:Karakas, E, Simorowski, N, Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
3QEM
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BU of 3qem by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, Glutamate [NMDA] receptor subunit epsilon-2, ...
Authors:Karakas, E, Simorowski, N, Furukawa, H.
Deposit date:2011-01-20
Release date:2011-06-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.003 Å)
Cite:Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors.
Nature, 475, 2011
3H5V
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BU of 3h5v by Molmil
Crystal structure of the GluR2-ATD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2
Authors:Jin, R, Singh, S.K, Gu, S, Furukawa, H, Sobolevsky, A, Zhou, J, Jin, Y, Gouaux, E.
Deposit date:2009-04-22
Release date:2009-06-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structure and association behaviour of the GluR2 amino-terminal domain.
Embo J., 28, 2009
3JPY
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BU of 3jpy by Molmil
Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ...
Authors:Karakas, E, Simorowski, N, Furukawa, H.
Deposit date:2009-09-04
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.209 Å)
Cite:Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
3JPW
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BU of 3jpw by Molmil
Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ...
Authors:Karakas, E, Simorowski, N, Furukawa, H.
Deposit date:2009-09-04
Release date:2009-12-08
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
3H5W
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BU of 3h5w by Molmil
Crystal structure of the GluR2-ATD in space group P212121 without solvent
Descriptor: Glutamate receptor 2
Authors:Jin, R, Singh, S.K, Gu, S, Furukawa, H, Sobolevsky, A, Zhou, J, Jin, Y, Gouaux, E.
Deposit date:2009-04-22
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.686 Å)
Cite:Crystal structure and association behaviour of the GluR2 amino-terminal domain.
Embo J., 28, 2009
5TQ0
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BU of 5tq0 by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in the presence of EDTA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ...
Authors:Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
5TPW
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BU of 5tpw by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at the GluN2A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ...
Authors:Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.909 Å)
Cite:Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
5TPZ
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BU of 5tpz by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 2B, ...
Authors:Romero-Hernandez, A, Simorwski, N, Karakas, E, Furukawa, H.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.095 Å)
Cite:Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
5U8C
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BU of 5u8c by Molmil
CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND NVP-AAM077
Descriptor: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A, GLYCEROL, ...
Authors:Romero-Hernandez, A, Furukawa, H.
Deposit date:2016-12-14
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
Mol. Pharmacol., 92, 2017
5TQ2
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BU of 5tq2 by Molmil
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2A in complex with zinc at GluN1 and GluN2A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB, HEAVY CHAIN, ...
Authors:Romero-Hernandez, A, Simorowski, N, Karakas, E, Furukawa, H.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.289 Å)
Cite:Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.
Neuron, 92, 2016
5B3J
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BU of 5b3j by Molmil
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Descriptor: Fab, heavy chain, light chain, ...
Authors:Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H.
Deposit date:2016-03-01
Release date:2016-05-11
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 534, 2016
3OEM
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BU of 3oem by Molmil
Crystal structure of GluN2D ligand-binding core in complex with N-methyl-D-aspartate
Descriptor: Glutamate [NMDA] receptor subunit epsilon-4, N-methyl-D-aspartic acid
Authors:Simorowski, N, Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEL
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BU of 3oel by Molmil
Crystal structure of GluN2D ligand-binding core in complex with D-glutamate
Descriptor: D-GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4
Authors:Simorowski, N, Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEK
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BU of 3oek by Molmil
Crystal structure of GluN2D ligand-binding core in complex with L-aspartate
Descriptor: ASPARTIC ACID, Glutamate [NMDA] receptor subunit epsilon-4
Authors:Simorowski, N, Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
3OEN
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BU of 3oen by Molmil
Crystal structure of GluN2D ligand-binding core in complex with L-glutamate
Descriptor: GLUTAMIC ACID, Glutamate [NMDA] receptor subunit epsilon-4
Authors:Simorowski, N, Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
4NF4
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BU of 4nf4 by Molmil
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate
Descriptor: 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ...
Authors:Annie, J, Tajima, N, Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
5FXH
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BU of 5fxh by Molmil
GluN1b-GluN2B NMDA receptor in non-active-1 conformation
Descriptor: N-METHYL-D-ASPARTATE RECEPTOR GLUN1, N-METHYL-D-ASPARTATE RECEPTOR GLUN2B
Authors:Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H.
Deposit date:2016-03-02
Release date:2016-05-11
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Activation of Nmda Receptors and the Mechanism of Inhibition by Ifenprodil.
Nature, 534, 2016
4PE5
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BU of 4pe5 by Molmil
Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ...
Authors:Karakas, E, Furukawa, H.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Crystal structure of a heterotetrameric NMDA receptor ion channel.
Science, 344, 2014
4NF5
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BU of 4nf5 by Molmil
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5
Descriptor: 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ...
Authors:Jespersen, A, Tajima, N, Furukawa, H.
Deposit date:2013-10-30
Release date:2014-03-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
6USV
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BU of 6usv by Molmil
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and SDZ 220-040
Descriptor: (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, GLYCEROL, GLYCINE, ...
Authors:Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, h.
Deposit date:2019-10-28
Release date:2020-07-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
6VAL
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BU of 6val by Molmil
Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera
Descriptor: Green fluorescent protein, CALHM1,CALMH2 chimera
Authors:Syrjanen, J.L, Chou, T.H, Furukawa, H.
Deposit date:2019-12-17
Release date:2020-01-29
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Structure and assembly of calcium homeostasis modulator proteins.
Nat.Struct.Mol.Biol., 27, 2020
6VAI
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BU of 6vai by Molmil
Cryo-EM structure of a dimer of undecameric human CALHM2
Descriptor: Calcium homeostasis modulator protein 2
Authors:Syrjanen, J.L, Chou, T.H, Furukawa, H.
Deposit date:2019-12-17
Release date:2020-01-29
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structure and assembly of calcium homeostasis modulator proteins.
Nat.Struct.Mol.Biol., 27, 2020

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數據於2024-06-12公開中

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