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2Y5G
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BU of 2y5g by Molmil
FACTOR XA - CATION INHIBITOR COMPLEX
Descriptor: 3-[(3AS,4R,5S,8AS,8BR)-4-[5-(5-CHLOROTHIOPHEN-2-YL)-1,3-OXAZOL-2-YL]-1,3-DIOXO-4,6,7,8,8A,8B-HEXAHYDRO-3AH-PYRROLO[3,4-A]PYRROLIZIN-2-YL]PROPYL-TRIMETHYL-AZANIUM, ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, ...
Authors:Banner, D.W, Salonen, L.M, Holland, M.C, Haap, W, Benz, J, Diederich, F.
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Molecular Recognition at the Active Site of Factor Xa: Cation-Pi Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water.
Chemistry, 18, 2012
2Y5H
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BU of 2y5h by Molmil
FACTOR XA - CATION INHIBITOR COMPLEX
Descriptor: 3-[(3AS,4R,5S,8AS,8BR)-4-[2-(5-CHLOROTHIOPHEN-2-YL)-1,3-OXAZOL-4-YL]-1,3-DIOXO-4,6,7,8,8A,8B-HEXAHYDRO-3AH-PYRROLO[3,4-A]PYRROLIZIN-2-YL]PROPYL-TRIMETHYL-AZANIUM, ACTIVATED FACTOR XA HEAVY CHAIN, FACTOR X LIGHT CHAIN, ...
Authors:Banner, D.W, Salonen, L.M, Holland, M.C, Haap, W, Benz, J, Diederich, F.
Deposit date:2011-01-13
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Molecular Recognition at the Active Site of Factor Xa: Cation-Pi Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water.
Chemistry, 18, 2012
1S38
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BU of 1s38 by Molmil
CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2-AMINO-8-METHYLQUINAZOLIN-4(3H)-ONE
Descriptor: 2-AMINO-8-METHYLQUINAZOLIN-4(3H)-ONE, ZINC ION, tRNA guanine transglycosylase
Authors:Meyer, E.A, Furler, M, Diederich, F, Brenk, R, Klebe, G.
Deposit date:2004-01-12
Release date:2004-07-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Synthesis and In vitro Evaluation of 2-Aminoquinazolin-4(3H)-one-based Inhibitors for tRNA-Guanine Transglycosylase (TGT)
HELV.CHIM.ACTA, 87, 2004
4AXM
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BU of 4axm by Molmil
TRIAZINE CATHEPSIN INHIBITOR COMPLEX
Descriptor: 4-[(4-chlorobenzyl)(cyclohexyl)amino]-6-morpholin-4-yl-1,3,5-triazine-2-carboxamide, CATHEPSIN L1, GLYCEROL
Authors:Ehmke, V, Diederich, F, Banner, D.W, Benz, J.
Deposit date:2012-06-13
Release date:2013-05-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-Ray Crystal Structure Analysis with Human Cathepsin L
Chemmedchem, 8, 2013
5J9O
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BU of 5j9o by Molmil
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 1-(2-(methylamino)-1H-benzo[d]imidazol-6-yl)guanidine
Descriptor: CHLORIDE ION, GLYCEROL, N-[2-(methylamino)-1H-benzimidazol-6-yl]guanidine, ...
Authors:Ehrmann, F.R, Heine, A, Klebe, G.
Deposit date:2016-04-10
Release date:2017-05-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Benzimidazole-based Inhibitors as a Novel Scaffold to Inhibit Z.mobilis TGT and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of lin-Benzopurines.
To be Published
5JGO
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BU of 5jgo by Molmil
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with allyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Ehrmann, F.R, Heine, A, Klebe, G.
Deposit date:2016-04-20
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Carbamate-protected lin-Benzoguanines as promising candidates for improving solubility and membrane permeability
To be published
5JGM
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BU of 5jgm by Molmil
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with ethyl (2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-6-yl)carbamate
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Ehrmann, F.R, Nguyen, D, Heine, A, Klebe, G.
Deposit date:2016-04-20
Release date:2017-05-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Carbamate-protected lin-Benzoguanines as promising candidates for improving solubility and membrane permeability
To be Published
5J9N
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BU of 5j9n by Molmil
tRNA guanine Transglycosylase (TGT) in co-crystallized complex with 2-(methylamino)-1H-benzo[d]imidazole-5-carbohydrazide
Descriptor: 2-(methylamino)-1H-benzimidazole-5-carbohydrazide, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Ehrmann, F.R, Heine, A, Klebe, G.
Deposit date:2016-04-10
Release date:2017-05-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Benzimidazole-based Inhibitors as a Novel Scaffold to Inhibit Z.mobilis TGT and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of lin-Benzopurines.
To be Published
1JR4
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BU of 1jr4 by Molmil
CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX
Descriptor: CATECHOL O-METHYLTRANSFERASE, SOLUBLE FORM, MAGNESIUM ION, ...
Authors:Ruf, A, Stihle, M.
Deposit date:2001-08-10
Release date:2002-08-10
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity.
Angew.Chem.Int.Ed.Engl., 40, 2001
1OYT
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BU of 1oyt by Molmil
COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
Descriptor: (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE, CALCIUM ION, Hirudin IIB, ...
Authors:Banner, D.W, Olsen, J.A.
Deposit date:2003-04-07
Release date:2003-06-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF...C=O Interactions.
Angew.Chem.Int.Ed.Engl., 42, 2003
3TLL
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BU of 3tll by Molmil
tRNA-Guanine Transglycosylase in complex with N-Ethyl-lin-benzoguanine Inhibitor
Descriptor: 6-(ethylamino)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Klebe, G, Immekus, F, Heine, A.
Deposit date:2011-08-30
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters.
Chemistry, 18, 2012
4FPS
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BU of 4fps by Molmil
tRNA-Guanine Transglycosylase in complex with adamantyl-substituted lin-benzoguanine ligand
Descriptor: 6-amino-2-(methylamino)-4-(2-{[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-ylmethyl]amino}ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-06-22
Release date:2013-07-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Studies on TGT homodimer interface
To be Published
4FR6
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BU of 4fr6 by Molmil
tRNA-Guanine Transglycosylase cocrystallized with pyridyl-alkine-substituted lin-benzoguanine ligand
Descriptor: 6-amino-2-(methylamino)-4-[2-({[trans-4-(pyridin-3-ylethynyl)cyclohexyl]methyl}amino)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Immekus, F, Klebe, G.
Deposit date:2012-06-26
Release date:2013-07-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Studies on TGT homodimer interface
To be Published
4FR1
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BU of 4fr1 by Molmil
tRNA-Guanine Transglycosylase cocrystallized with alkine-substituted lin-benzoguanine ligand
Descriptor: 6-amino-4-[2-({[trans-4-(biphenyl-4-ylethynyl)cyclohexyl]methyl}amino)ethyl]-2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Immekus, F, Klebe, G.
Deposit date:2012-06-26
Release date:2013-07-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Studies on TGT homodimer interface
To be Published
4FSA
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BU of 4fsa by Molmil
tRNA-Guanine Transglycosylase soaked with pyridyl-alkine-substituted lin-benzoguanine ligand
Descriptor: 6-amino-2-(methylamino)-4-[2-({[trans-4-(pyridin-3-ylethynyl)cyclohexyl]methyl}amino)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-06-27
Release date:2013-07-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Studies on TGT homodimer interface
To be Published
4GI4
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BU of 4gi4 by Molmil
tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
Descriptor: 6-amino-4-[2-(benzylamino)ethyl]-2-[(2-phenylethyl)amino]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-08
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
4GG9
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BU of 4gg9 by Molmil
tRNA Guanine Transglycosylase in complex with thiophene-substituted lin-benzohypoxanthine inhibitor
Descriptor: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(thiophen-2-ylmethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-06
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
4GHR
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BU of 4ghr by Molmil
TGT D102N mutant in complex with lin-benzohypoxanthine inhibitor
Descriptor: 2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-08
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protonation state analysis of the TGT active site
To be Published
4GH3
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BU of 4gh3 by Molmil
tRNA Guanine Transglycosylase in complex with phenethyl substituted lin-benzohypoxanthine inhibitor
Descriptor: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-07
Release date:2013-09-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
4GKT
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BU of 4gkt by Molmil
tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
Descriptor: 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-13
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
4GH1
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BU of 4gh1 by Molmil
tRNA Guanine Transglycosylase in complex with morpholine substituted lin-benzohypoxanthine inhibitor
Descriptor: 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ...
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-07
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
4GIY
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BU of 4giy by Molmil
tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
Descriptor: 6-amino-4-{2-[(cyclohexylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Immekus, F, Klebe, G.
Deposit date:2012-08-09
Release date:2013-09-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Two-armed benzopurine inhibitors of TGT
To be Published
2YC3
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BU of 2yc3 by Molmil
Inhibitors of the herbicidal target IspD
Descriptor: 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, 6-benzyl-5-chloro[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-11
Release date:2011-08-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011
2YCM
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BU of 2ycm by Molmil
Inhibitors of herbicidal target IspD
Descriptor: 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, 6-BENZYL-5-CHLORO-7-HYDROXYPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-16
Release date:2011-08-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011
2YC5
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BU of 2yc5 by Molmil
Inhibitors of the herbicidal target IspD
Descriptor: 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC, 5-chloro-7-hydroxy-6-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, ...
Authors:Hoeffken, H.W.
Deposit date:2011-03-11
Release date:2011-08-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Angew.Chem.Int.Ed.Engl., 50, 2011

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數據於2024-06-19公開中

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