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3FCX
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BU of 3fcx by Molmil
Crystal structure of human esterase D
Descriptor: CALCIUM ION, MAGNESIUM ION, S-formylglutathione hydrolase
Authors:Wu, D, Li, Y, Song, G, Zhang, D, Shaw, N, Liu, Z.J.
Deposit date:2008-11-24
Release date:2008-12-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human esterase D: a potential genetic marker of retinoblastoma
Faseb J., 23, 2009
3FL2
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BU of 3fl2 by Molmil
Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1
Descriptor: E3 ubiquitin-protein ligase UHRF1, ZINC ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-12-18
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of the Ring Domain of the E3 Ubiquitin-Protein Ligase Uhrf1
To be Published
5VBT
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BU of 5vbt by Molmil
Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
Descriptor: UBH04
Authors:DONG, A, DONG, X, LIU, L, GUO, Y, LI, Y, ZHANG, W, WALKER, J.R, SIDHU, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC)
Deposit date:2017-03-30
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published
4JUY
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BU of 4juy by Molmil
Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31
Descriptor: E3 ubiquitin-protein ligase RNF31, UNKNOWN ATOM OR ION
Authors:Dong, A, Hu, J, Li, Y, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2013-03-25
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PUB domain of E3 ubiquitin ligase RNF31
To be Published
1WM8
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BU of 1wm8 by Molmil
Solution Structure of BmP03 from the Venom of Scorpion Buthus martensii Karsch, 10 structures
Descriptor: Neurotoxin BmP03
Authors:Wu, H, He, F, Li, Y, Wu, G, Cao, C, Chen, X.
Deposit date:2004-07-05
Release date:2004-07-27
Last modified:2018-04-18
Method:SOLUTION NMR
Cite:Three-Dimensional Structure of BmP03 from Venom of Scorpion Buthus martensii Karsch
Acta Chim.Sinica, 58, 2000
1WT8
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BU of 1wt8 by Molmil
Solution Structure of BmP08 from the Venom of Scorpion Buthus martensii Karsch, 20 structures
Descriptor: Neurotoxin BmK X
Authors:Wu, H, Chen, X, Tong, X, Li, Y, Zhang, N, Wu, G.
Deposit date:2004-11-17
Release date:2005-04-19
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of BmP08, a novel short-chain scorpion toxin from Buthus martensi Karsch.
Biochem.Biophys.Res.Commun., 330, 2005
3HD1
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BU of 3hd1 by Molmil
Crystal structure of E. coli HPPK(N10A) in complex with MgAMPCPP
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, CHLORIDE ION, ...
Authors:Blaszczyk, J, Li, Y, Yan, H, Ji, X.
Deposit date:2009-05-06
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Role of loop coupling in enzymatic catalysis and conformational dynamics
To be Published
1WM7
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BU of 1wm7 by Molmil
Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch, 9 structures
Descriptor: Neurotoxin BmP01
Authors:Wu, G, Li, Y, Wei, D, He, F, Jiang, S, Hu, G, Wu, H, Chen, X.
Deposit date:2004-07-05
Release date:2004-07-27
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution Structure of BmP01 from the Venom of Scorpion Buthus martensii Karsch
Biochem.Biophys.Res.Commun., 276, 2000
3G1N
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BU of 3g1n by Molmil
Catalytic domain of the human E3 ubiquitin-protein ligase HUWE1
Descriptor: E3 ubiquitin-protein ligase HUWE1, SODIUM ION
Authors:Walker, J.R, Qiu, L, Li, Y, Davis, T, Tempel, W, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-01-30
Release date:2009-02-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Hect Domain of Human HUWE1/MULE
To be Published
3HY4
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BU of 3hy4 by Molmil
Structure of human MTHFS with N5-iminium phosphate
Descriptor: 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({trans-4-[({(2R,4R,4aS,6S,8aS)-2-amino-4-hydroxy-5-[(phosphonooxy)methyl]decahydropteridin-6-yl}methyl)amino]cyclohexyl}carbonyl)-L-glutamic acid, ...
Authors:Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J.
Deposit date:2009-06-22
Release date:2009-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.795 Å)
Cite:Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Cancer Res., 69, 2009
3HY6
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BU of 3hy6 by Molmil
Structure of human MTHFS with ADP
Descriptor: 5-formyltetrahydrofolate cyclo-ligase, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J.
Deposit date:2009-06-22
Release date:2009-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Cancer Res., 69, 2009
3HY3
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BU of 3hy3 by Molmil
Structure of human MTHFS with 10-formyltetrahydrofolate
Descriptor: 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, N-({4-[{[(2R,4S,4aR,6S,8aS)-2-amino-4-hydroxydecahydropteridin-6-yl]methyl}(formyl)amino]phenyl}carbonyl)-D-glutamic acid, ...
Authors:Wu, D, Li, Y, Song, G, Cheng, C, Shaw, N, Liu, Z.-J.
Deposit date:2009-06-22
Release date:2009-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Cancer Res., 69, 2009
3HXT
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BU of 3hxt by Molmil
Structure of human MTHFS
Descriptor: 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, NICKEL (II) ION
Authors:Wu, D, Li, Y, Song, G, Cheng, C, Zhang, R, Joachimiak, A, Shaw, N, Liu, Z.-J.
Deposit date:2009-06-22
Release date:2009-07-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues
Cancer Res., 69, 2009
3I2V
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BU of 3i2v by Molmil
Crystal structure of human MOCS3 rhodanese-like domain
Descriptor: Adenylyltransferase and sulfurtransferase MOCS3
Authors:Bacik, J.P, Walker, J.R, Lopez, L, Li, Y, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-06-29
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of the human MOCS3 rhodanese-like domain
To be Published
7WMO
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BU of 7wmo by Molmil
A novel chemical derivative(92) of THRB agonist
Descriptor: 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-15
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WML
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BU of 7wml by Molmil
A novel chemical derivative(85) of THRB agonist
Descriptor: 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-15
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WMJ
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BU of 7wmj by Molmil
A novel chemical derivative(71) of THRB agonist
Descriptor: 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-14
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WLX
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BU of 7wlx by Molmil
A novel chemical derivative(53) of THRB agonist
Descriptor: 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-14
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WMH
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BU of 7wmh by Molmil
A novel chemical derivative(56) of THRB agonist
Descriptor: 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-14
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WMG
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BU of 7wmg by Molmil
A novel chemical derivative(52) of THRB agonist
Descriptor: 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-14
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
7WMN
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BU of 7wmn by Molmil
A novel chemical derivative(89) of THRB agonist
Descriptor: 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2
Authors:Yao, B.Q, Li, Y.
Deposit date:2022-01-15
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
J.Med.Chem., 65, 2022
8URF
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BU of 8urf by Molmil
Crystal Structure of human ASGR2 CRD (Carbohydrate Recognition Domain) bound to 8G8 Fab
Descriptor: 8G8 Fab Heavy Chain, 8G8 Fab Light Chain, Asialoglycoprotein receptor 2, ...
Authors:Sampathumar, P, Li, Y.
Deposit date:2023-10-25
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeted protein degradation systems to enhance Wnt signaling.
Elife, 13, 2024
1X9M
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BU of 1x9m by Molmil
T7 DNA polymerase in complex with an N-2-acetylaminofluorene-adducted DNA
Descriptor: 5'-D(*CP*CP*CP*(8FG)P*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*TP*GP*GP*TP*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', DNA polymerase, ...
Authors:Dutta, S, Li, Y, Johnson, D, Dzantiev, L, Richardson, C.C, Romano, L.J, Ellenberger, T.
Deposit date:2004-08-23
Release date:2004-10-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Proc.Natl.Acad.Sci.USA, 101, 2004
1X9W
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BU of 1x9w by Molmil
T7 DNA polymerase in complex with a primer/template DNA containing a disordered N-2 aminofluorene on the template, crystallized with dideoxy-ATP as the incoming nucleotide.
Descriptor: 5'-D(*CP*CP*CP*(AFG)*AP*TP*CP*AP*CP*AP*CP*TP*AP*CP*CP*AP*AP*TP*CP*AP*CP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*GP*TP*GP*AP*TP*T*GP*GP*T*AP*GP*TP*GP*TP*GP*AP*(2DT))-3', DNA polymerase, ...
Authors:Dutta, S, Li, Y, Johnson, D, Dzantiev, L, Richardson, C.C, Romano, L.J, Ellenberger, T.
Deposit date:2004-08-24
Release date:2004-10-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Proc.Natl.Acad.Sci.Usa, 101, 2004
3GV4
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BU of 3gv4 by Molmil
Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG
Descriptor: CALCIUM ION, Histone deacetylase 6, ZINC ION, ...
Authors:Dong, A, Ravichandran, M, Loppnau, P, Li, Y, MacKenzie, F, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Dhe-Paganon, S, Min, J, Ouyang, H, Structural Genomics Consortium (SGC)
Deposit date:2009-03-30
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG
To be Published

221716

數據於2024-06-26公開中

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