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6WOL
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BU of 6wol by Molmil
Next generation monomeric IgG4 Fc bound to neonatal Fc receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, IgG receptor FcRn large subunit p51, ...
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-24
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
5HVW
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BU of 5hvw by Molmil
Monomeric IgG4 Fc
Descriptor: GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ...
Authors:Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F.
Deposit date:2016-01-28
Release date:2016-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Generation and Characterization of an IgG4 Monomeric Fc Platform.
Plos One, 11, 2016
1C3H
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BU of 1c3h by Molmil
ACRP30 CALCIUM COMPLEX
Descriptor: 30 KD ADIPOCYTE COMPLEMENT-RELATED PROTEIN PRECURSOR, CALCIUM ION
Authors:Shapiro, L, Boggon, T, Scherer, P.
Deposit date:1999-07-27
Release date:2003-12-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:ACRP30 calcium complex
To Be Published
6BTJ
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BU of 6btj by Molmil
Crystal structure of pan-H7, anti-hemagglutinin monoclonal antibody H7.5 (Fab fragment)
Descriptor: Heavy chain of H7.5 Fab, Light chain of H7.5 Fab
Authors:Shanshan, L, Ian, A.W.
Deposit date:2017-12-06
Release date:2018-12-19
Last modified:2023-02-22
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Crystal structure of pan-H7, anti-hemagglutinin monoclonal antibody H7.5 (Fab fragment)
To Be Published
3K6I
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BU of 3k6i by Molmil
Crystal structure of chicken T-cadherin EC1
Descriptor: T-cadherin, ZINC ION
Authors:Shapiro, L, Ciatto, C.
Deposit date:2009-10-08
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:T-cadherin structures reveal a novel adhesive binding mechanism
Nat.Struct.Mol.Biol., 17, 2010
3K6F
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BU of 3k6f by Molmil
Crystal structure of mouse T-cadherin EC1
Descriptor: T-cadherin
Authors:Shapiro, L, Ciatto, C.
Deposit date:2009-10-08
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.813 Å)
Cite:T-cadherin structures reveal a novel adhesive binding mechanism
Nat.Struct.Mol.Biol., 17, 2010
3K5R
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BU of 3k5r by Molmil
Crystal Structure of mouse T-cadherin EC1 EC2
Descriptor: Cadherin 13
Authors:Shapiro, L, Ciatto, C.
Deposit date:2009-10-07
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:T-cadherin structures reveal a novel adhesive binding mechanism
Nat.Struct.Mol.Biol., 17, 2010
3K6D
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BU of 3k6d by Molmil
Crystal structure of Xenopus laevis T-cadherin EC1
Descriptor: T-cadherin, ZINC ION
Authors:Shapiro, L, Ciatto, C.
Deposit date:2009-10-08
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:T-cadherin structures reveal a novel adhesive binding mechanism
Nat.Struct.Mol.Biol., 17, 2010
3K5S
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BU of 3k5s by Molmil
Crystal structure of chicken T-cadherin EC1 EC2
Descriptor: CALCIUM ION, Cadherin-13
Authors:Shapiro, L, Ciatto, C.
Deposit date:2009-10-07
Release date:2010-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:T-cadherin structures reveal a novel adhesive binding mechanism
Nat.Struct.Mol.Biol., 17, 2010
4V0G
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BU of 4v0g by Molmil
JAK3 in complex with a covalent EGFR inhibitor
Descriptor: N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, TYROSINE-PROTEIN KINASE JAK3
Authors:Debreczeni, J.E, Hennessy, E.J, Chuaquini, C, Ashton, S, Coclough, N, Cross, D.A.E, Eberlein, C, Gingipalli, L, Klinowska, T.C.M, Orme, J.P, Sha, L, Wu, X.
Deposit date:2014-09-16
Release date:2016-01-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation
To be Published
4H58
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BU of 4h58 by Molmil
BRAF in complex with compound 3
Descriptor: CHLORIDE ION, N-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine, Serine/threonine-protein kinase B-raf
Authors:Vasbinder, M, Aquila, B, Augustin, M, Chueng, T, Cook, D, Drew, L, Fauber, B, Glossop, S, Godin, R, Grondine, M, Hennessy, E, Johannes, J, Lee, S, Lyne, P, Moertl, M, Omer, C, Palakurthi, S, Pontz, T, Read, J, Sha, L, Shen, M, Steinbacher, S, Wang, H, Wu, A, Ye, M, Bagal, B.
Deposit date:2012-09-18
Release date:2013-02-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery and Optimization of a Novel Series of Potent Mutant B-Raf(V600E) Selective Kinase Inhibitors.
J.Med.Chem., 56, 2013
8DXS
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BU of 8dxs by Molmil
Cryo-EM structure of RBD-directed neutralizing antibody P2B4 in complex with prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, P2B4 Heavy chain, P2B4 Light chain, ...
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-03
Release date:2022-12-07
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
8DW9
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BU of 8dw9 by Molmil
Crystal structure of neutralizing antibody D29 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD)
Descriptor: D29 Fab light chain, D29 Heavy chain, Spike protein S1
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-01
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
8DWA
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BU of 8dwa by Molmil
Crystal structure of neutralizing antibody P1D9 Fab in complex with SARS-CoV-2 spike receptor binding domain (RBD)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, P1D9 Heavy chain, P1D9 Light chain, ...
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-08-01
Release date:2022-12-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2.
Emerg Microbes Infect, 12, 2023
7M8K
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BU of 7m8k by Molmil
Cryo-EM structure of Brazil (P.1) SARS-CoV-2 spike glycoprotein variant in the prefusion state (1 RBD up)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Casner, R.G, Cerutti, G, Shapiro, L, Ho, D.D.
Deposit date:2021-03-29
Release date:2021-05-05
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY
Cite:Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization.
Cell Host Microbe, 29, 2021
1Q7E
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BU of 1q7e by Molmil
Crystal Structure of YfdW protein from E. coli
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Hypothetical protein yfdW, METHIONINE
Authors:Gogos, A, Gorman, J, Shapiro, L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-08-18
Release date:2003-09-30
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Escherichia coli YfdW, a type III CoA transferase.
Acta Crystallogr.,Sect.D, 60, 2004
6EG0
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BU of 6eg0 by Molmil
Crystal structure of Dpr4 Ig1-Ig2 in complex with DIP-Eta Ig1-Ig3
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Cosmanescu, F, Shapiro, L.
Deposit date:2018-08-17
Release date:2018-11-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Neuron, 100, 2018
6EG1
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BU of 6eg1 by Molmil
Crystal structure of Dpr2 Ig1-Ig2 in complex with DIP-Theta Ig1-Ig3
Descriptor: (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Cosmanescu, F, Patel, S, Shapiro, L.
Deposit date:2018-08-17
Release date:2018-11-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Neuron, 100, 2018
6EFY
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BU of 6efy by Molmil
Crystal Structure of DIP-Alpha Ig1-3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Dpr-interacting protein alpha, isoform A, ...
Authors:Cosmanescu, F, Shapiro, L.
Deposit date:2018-08-17
Release date:2018-11-28
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Neuron, 100, 2018
6EFZ
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BU of 6efz by Molmil
Crystal Structure of DIP-Theta Ig1-3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Cosmanescu, F, Shapiro, L.
Deposit date:2018-08-17
Release date:2018-11-28
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.499 Å)
Cite:Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Neuron, 100, 2018
1ZWK
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BU of 1zwk by Molmil
Structure of WrbA from Pseudomonas aeruginosa
Descriptor: PHOSPHATE ION, Trp repressor binding protein WrbA
Authors:Gorman, J, Shapiro, L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2005-06-03
Release date:2005-06-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide.
Protein Sci., 14, 2005
1ZXK
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BU of 1zxk by Molmil
Crystal Structure of Cadherin8 EC1 domain
Descriptor: Cadherin-8
Authors:Patel, S.D, Ciatto, C, Chen, C.P, Bahna, F, Arkus, N, Schieren, I, Rajebhosale, M, Jessell, T.M, Honig, B, Price, S.R, Shapiro, L.
Deposit date:2005-06-08
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Cell(Cambridge,Mass.), 124, 2006
8CSJ
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BU of 8csj by Molmil
Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(2-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Reddem, E.R, Shapiro, L.
Deposit date:2022-05-12
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Cryo-EM structure of NTD-directed non-neutralizing antibody 4-33 in complex with prefusion SARS-CoV-2 spike glycoprotein
To Be Published
2A1F
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BU of 2a1f by Molmil
Crystal Structure of Uridylate kinase
Descriptor: Uridylate kinase
Authors:Gorman, J, Shapiro, L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2005-06-20
Release date:2005-06-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Uridylate kinase
To be Published
2A4C
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BU of 2a4c by Molmil
Crystal structure of mouse cadherin-11 EC1
Descriptor: Cadherin-11
Authors:Patel, S.D, Ciatto, C, Chen, C.P, Bahna, F, Schieren, I, Rajebhosale, M, Jessell, T.M, Honig, B, Price, S.R, Shapiro, L.
Deposit date:2005-06-28
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Type II cadherin ectodomain structures: implications for classical cadherin specificity.
Cell(Cambridge,Mass.), 124, 2006

226707

數據於2024-10-30公開中

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