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5TJG
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BU of 5tjg by Molmil
Thermus aquaticus delta1.1-sigmaA holoenzyme/downstream-fork promoter complex with an open clamp
Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*A)-3'), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Darst, S.A, Bae, B.
Deposit date:2016-10-04
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:RNA polymerase motions during promoter melting.
Science, 356, 2017
4XLN
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BU of 4xln by Molmil
Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA
Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XLQ
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BU of 4xlq by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11 base-paired) promoter
Descriptor: DNA (26-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XSZ
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BU of 4xsz by Molmil
Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme
Descriptor: 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-22
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.683 Å)
Cite:CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XSX
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BU of 4xsx by Molmil
Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-22
Release date:2015-07-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.708 Å)
Cite:CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XLP
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BU of 4xlp by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter
Descriptor: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Bae, B, Darst, S.A.
Deposit date:2015-01-13
Release date:2015-09-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
2O5J
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BU of 2o5j by Molmil
Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the NTP substrate analog
Descriptor: 5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3', 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*GP*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP*G)-3', ...
Authors:Vassylyev, D.G, Vassylyeva, M.N.
Deposit date:2006-12-06
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for substrate loading in bacterial RNA polymerase.
Nature, 448, 2007
3LTI
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BU of 3lti by Molmil
Crystal structure of the Escherichia coli RNA polymerase beta subunit beta2-betai4 domains
Descriptor: DNA-directed RNA polymerase subunit beta
Authors:Darst, S.A, Opalka, N.
Deposit date:2010-02-16
Release date:2010-10-20
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
3LU0
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BU of 3lu0 by Molmil
Molecular model of Escherichia coli core RNA polymerase
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A.
Deposit date:2010-02-16
Release date:2010-09-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (11.2 Å)
Cite:Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.
Plos Biol., 8, 2010
7KRP
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BU of 7krp by Molmil
Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ...
Authors:Chen, J, Malone, B, Campbell, E.A, Darst, S.A.
Deposit date:2020-11-20
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7KRO
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BU of 7kro by Molmil
Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ...
Authors:Chen, J, Malone, B, Campbell, E.A, Darst, S.A.
Deposit date:2020-11-20
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7KRN
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BU of 7krn by Molmil
Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ...
Authors:Chen, J, Malone, B, Campbell, E.A, Darst, S.A.
Deposit date:2020-11-20
Release date:2021-04-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
7L7B
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BU of 7l7b by Molmil
Clostridioides difficile RNAP with fidaxomicin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J.
Deposit date:2020-12-28
Release date:2022-02-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
Nature, 604, 2022
8E8M
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BU of 8e8m by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-25
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E79
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BU of 8e79 by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex with Escherichia coli NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E95
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BU of 8e95 by Molmil
Mycobacterium tuberculosis RNAP elongation complex
Descriptor: DNA (25-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-26
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E74
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BU of 8e74 by Molmil
Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-23
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
8E82
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BU of 8e82 by Molmil
Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor
Descriptor: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Delbeau, M, Darst, S.A, Campbell, E.A.
Deposit date:2022-08-25
Release date:2023-03-22
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Mol.Cell, 83, 2023
4L5G
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BU of 4l5g by Molmil
Crystal structure of Thermus thermophilus CarD
Descriptor: CarD
Authors:Srivastava, D.B, Westblade, L.F, Campbell, E.A, Darst, S.A.
Deposit date:2013-06-11
Release date:2013-07-31
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.3902 Å)
Cite:Structure and function of CarD, an essential mycobacterial transcription factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
2JVV
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BU of 2jvv by Molmil
Solution Structure of E. coli NusG carboxyterminal domain
Descriptor: Transcription antitermination protein nusG
Authors:Schweimer, K, Scheckenhofer, U, Roesch, P.
Deposit date:2007-09-26
Release date:2008-10-14
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Two structurally independent domains of E. coli NusG create regulatory plasticity via distinct interactions with RNA polymerase and regulators.
J.Mol.Biol., 391, 2009
2K06
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BU of 2k06 by Molmil
Solution structure of the aminoterminal domain of E. coli NusG
Descriptor: Transcription antitermination protein nusG
Authors:Schweimer, K, Scheckenhofer, U, Roesch, P.
Deposit date:2008-01-25
Release date:2009-02-03
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Two structurally independent domains of E. coli NusG create regulatory plasticity via distinct interactions with RNA polymerase and regulators.
J.Mol.Biol., 391, 2009
2LCL
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BU of 2lcl by Molmil
Solution Structure of RfaH carboxyterminal domain
Descriptor: Transcriptional activator rfaH
Authors:Burmann, B.M, Schweimer, K, Roesch, P.
Deposit date:2011-05-02
Release date:2012-08-01
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:An alpha helix to beta barrel domain switch transforms the transcription factor RfaH into a translation factor.
Cell(Cambridge,Mass.), 150, 2012
7UO9
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BU of 7uo9 by Molmil
SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UO7
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BU of 7uo7 by Molmil
SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023
7UOB
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BU of 7uob by Molmil
SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state
Descriptor: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A.
Deposit date:2022-04-12
Release date:2022-11-30
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis for substrate selection by the SARS-CoV-2 replicase.
Nature, 614, 2023

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數據於2024-05-29公開中

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