2EAR
| P21 crystal of the SR CA2+-ATPase with bound TG | Descriptor: | OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, ... | Authors: | Takahashi, M, Kondou, Y, Toyoshima, C. | Deposit date: | 2007-02-02 | Release date: | 2007-03-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104, 2007
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1X0G
| Crystal Structure of IscA with the [2Fe-2S] cluster | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IscA, SODIUM ION | Authors: | Morimoto, K, Yamashita, E, Kondou, Y, Lee, S.J, Tsukihara, T, Nakai, M. | Deposit date: | 2005-03-22 | Release date: | 2006-06-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Asymmetric IscA Homodimer with an Exposed [2Fe-2S] Cluster Suggests the Structural Basis of the Fe-S Cluster Biosynthetic Scaffold. J.Mol.Biol., 360, 2006
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1MNI
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5VFC
| WDR5 bound to inhibitor MM-589 | Descriptor: | 1,2-ETHANEDIOL, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ... | Authors: | Stuckey, J.A. | Deposit date: | 2017-04-07 | Release date: | 2017-06-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J. Med. Chem., 60, 2017
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6WZW
| Ash1L SET domain in complex with AS-85 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ... | Authors: | Li, H, Deng, J, Cierpicki, T, Grembecka, J. | Deposit date: | 2020-05-14 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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6X0P
| Ash1L SET domain Q2265A mutant in complex with AS-5 | Descriptor: | 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ... | Authors: | Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J. | Deposit date: | 2020-05-17 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun, 12, 2021
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1MLU
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4DNC
| Crystal structure of human MOF in complex with MSL1 | Descriptor: | Histone acetyltransferase KAT8, Male-specific lethal 1 homolog, ZINC ION | Authors: | Huang, J, Lei, M. | Deposit date: | 2012-02-08 | Release date: | 2012-07-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res., 22, 2012
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6O7G
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6O5I
| Menin in complex with MI-3454 | Descriptor: | DIMETHYL SULFOXIDE, Menin, SULFATE ION, ... | Authors: | Linhares, B.M, Klossowski, S, Cierpicki, T, Grembecka, J. | Deposit date: | 2019-03-03 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.24025619 Å) | Cite: | Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J.Clin.Invest., 130, 2020
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5F6L
| The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F5E
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5F6K
| Crystal structure of the MLL3-Ash2L-RbBP5 complex | Descriptor: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-06 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.411 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F59
| The crystal structure of MLL3 SET domain | Descriptor: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Li, Y, Lei, M, Chen, Y. | Deposit date: | 2015-12-04 | Release date: | 2016-02-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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2MBW
| RECOMBINANT SPERM WHALE MYOGLOBIN (MET) | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Brucker, E.A, Phillips Jr, G.N. | Deposit date: | 1996-06-20 | Release date: | 1996-12-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin. J.Biol.Chem., 271, 1996
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1YOH
| COBALT MYOGLOBIN (MET) | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING CO, SULFATE ION | Authors: | Brucker, E.A, Phillips Jr, G.N. | Deposit date: | 1996-06-14 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin. J.Biol.Chem., 271, 1996
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1YOI
| COBALT MYOGLOBIN (OXY) | Descriptor: | MYOGLOBIN, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING CO, ... | Authors: | Brucker, E.A, Phillips Jr, G.N. | Deposit date: | 1996-06-14 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin. J.Biol.Chem., 271, 1996
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1YOG
| COBALT MYOGLOBIN (DEOXY) | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING CO, SULFATE ION | Authors: | Brucker, E.A, Phillips Jr, G.N. | Deposit date: | 1996-06-14 | Release date: | 1996-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin. J.Biol.Chem., 271, 1996
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1MLS
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1CO9
| RECOMBINANT SPERM WHALE MYOGLOBIN L104V MUTANT (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-06-07 | Release date: | 1999-06-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J.Biol.Chem., 276, 2001
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1CH7
| RECOMBINANT SPERM WHALE MYOGLOBIN H97F MUTANT (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-03-31 | Release date: | 1999-04-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J.Biol.Chem., 276, 2001
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1CP0
| RECOMBINANT SPERM WHALE MYOGLOBIN L104N MUTANT (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-06-07 | Release date: | 1999-06-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J.Biol.Chem., 276, 2001
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1CPW
| RECOMBINANT SPERM WHALE MYOGLOBIN L104W MUTANT (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-06-07 | Release date: | 1999-06-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J.Biol.Chem., 276, 2001
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1CH1
| Recombinant sperm whale myoglobin L89G mutatnt (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-03-31 | Release date: | 1999-04-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin J.Biol.Chem., 276, 2001
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1CH3
| RECOMBINANT SPERM WHALE MYOGLOBIN L89W MUTANT (MET) | Descriptor: | PROTEIN (MYOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Liong, E.C, Phillips Jr, G.N. | Deposit date: | 1999-03-31 | Release date: | 1999-04-09 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J.Biol.Chem., 276, 2001
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