4P8Y
| Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor Ty21c | Descriptor: | 3-[(4-methoxybenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... | Authors: | Neres, J, Pojer, F, Cole, S.T. | Deposit date: | 2014-04-01 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
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3CXZ
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5J5R
| M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718 | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, cyclohexyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone | Authors: | Pacitto, A, Ascher, D.B, Blundell, T.L. | Deposit date: | 2016-04-03 | Release date: | 2016-10-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. ACS Infect Dis, 3, 2017
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2BMX
| Mycobacterium tuberculosis AhpC | Descriptor: | ALKYL HYDROPEROXIDASE C | Authors: | Guimaraes, B.G, Alzari, P.M. | Deposit date: | 2005-03-16 | Release date: | 2005-05-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Mechanism of the Alkyl Hydroperoxidase Ahpc, a Key Element of the Mycobacterium Tuberculosis Defense System Against Oxidative Stress. J.Biol.Chem., 280, 2005
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2CKD
| Crystal structure of ML2640 from Mycobacterium leprae | Descriptor: | PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE ML2640 | Authors: | Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Alzari, P.M. | Deposit date: | 2006-04-17 | Release date: | 2007-05-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria. Protein Sci., 16, 2007
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2G9W
| Crystal Structure of Rv1846c, a Putative Transcriptional Regulatory Protein of Mycobacterium Tuberculosis | Descriptor: | CHLORIDE ION, conserved hypothetical protein | Authors: | Saul, F.A, Haouz, A, Fiez-Vandal, C, Shepard, W, Alzari, P.M. | Deposit date: | 2006-03-07 | Release date: | 2007-03-13 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis Mol.Microbiol., 71, 2009
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2UYQ
| Crystal structure of ML2640c from Mycobacterium leprae in complex with S-adenosylmethionine | Descriptor: | HYPOTHETICAL PROTEIN ML2640, S-ADENOSYLMETHIONINE | Authors: | Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Miras, I, Shepard, W, Alzari, P.M. | Deposit date: | 2007-04-11 | Release date: | 2007-08-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria. Protein Sci., 16, 2007
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2WZV
| Crystal structure of the FMN-dependent nitroreductase NfnB from Mycobacterium smegmatis | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, NFNB PROTEIN, ... | Authors: | Bellinzoni, M, Manina, G, Riccardi, G, Alzari, P.M. | Deposit date: | 2009-12-03 | Release date: | 2010-07-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance Mol.Microbiol., 77, 2010
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2UYO
| Crystal structure of ML2640c from Mycobacterium leprae in an hexagonal crystal form | Descriptor: | HYPOTHETICAL PROTEIN ML2640 | Authors: | Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Miras, I, Shepard, W, Alzari, P.M. | Deposit date: | 2007-04-11 | Release date: | 2007-08-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria. Protein Sci., 16, 2007
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2WZW
| Crystal structure of the FMN-dependent nitroreductase NfnB from Mycobacterium smegmatis in complex with NADPH | Descriptor: | FLAVIN MONONUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NFNB PROTEIN, ... | Authors: | Bellinzoni, M, Manina, G, Riccardi, G, Alzari, P.M. | Deposit date: | 2009-12-03 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance Mol.Microbiol., 77, 2010
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6TOB
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4XWP
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4XY3
| Structure of ESX-1 secreted protein EspB | Descriptor: | ESX-1 secretion-associated protein EspB | Authors: | Wagner, J.M, Korotkov, K.V. | Deposit date: | 2015-02-01 | Release date: | 2015-02-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.04 Å) | Cite: | Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. J.Struct.Biol., 191, 2015
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4XXN
| Structure of PE-PPE domains of ESX-1 secreted protein EspB, I222 | Descriptor: | CHLORIDE ION, ESX-1 secretion-associated protein EspB, SODIUM ION | Authors: | Korotkov, K.V. | Deposit date: | 2015-01-30 | Release date: | 2015-02-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. J.Struct.Biol., 191, 2015
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4XXX
| Structure of PE-PPE domains of ESX-1 secreted protein EspB, C2221 | Descriptor: | CHLORIDE ION, ESX-1 secretion-associated protein EspB, GLYCEROL | Authors: | Piton, J, Pojer, F, Korotkov, K.V. | Deposit date: | 2015-01-30 | Release date: | 2015-02-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis. J.Struct.Biol., 191, 2015
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4ZDJ
| Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | Descriptor: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | Deposit date: | 2015-04-17 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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4ZDI
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4ZDK
| Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine | Descriptor: | 5-OXO-L-NORLEUCINE, CTP synthase, MAGNESIUM ION, ... | Authors: | Bellinzoni, M, Barilone, N, Alzari, P.M. | Deposit date: | 2015-04-17 | Release date: | 2015-07-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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3CY0
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3CXY
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3CY1
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3CXV
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3CXX
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4BYY
| Apo GlxR | Descriptor: | GLYCEROL, PHOSPHATE ION, TRANSCRIPTIONAL REGULATOR, ... | Authors: | Pohl, E, Cann, M.J, Townsend, P.D, Money, V.A. | Deposit date: | 2013-07-21 | Release date: | 2014-07-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The Crystal Structures of Apo and Camp-Bound Glxr from Corynebacterium Glutamicum Reveal Structural and Dynamic Changes Upon Camp Binding in Crp/Fnr Family Transcription Factors. Plos One, 9, 2014
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4CYD
| GlxR bound to cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, PROBABLE EXPRESSION TAG, ... | Authors: | Townsend, P.D, Bott, M, Cann, M.J, Pohl, E. | Deposit date: | 2014-04-10 | Release date: | 2014-12-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The Crystal Structures of Apo and Camp-Bound Glxr from Corynebacterium Glutamicum Reveal Structural and Dynamic Changes Upon Camp Binding in Crp/Fnr Family Transcription Factors. Plos One, 9, 2014
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