4GIW
| |
7VO5
| Pimaricin type I PKS thioesterase domain (holo Pim TE) | Descriptor: | (1R,3S,5E,7S,11R,13E,15E,17E,19E,21R,23S,24R,25S)-11,24-dimethyl-1,3,7,21,25-pentakis(oxidanyl)-10,27-dioxabicyclo[21.3.1]heptacosa-5,13,15,17,19-pentaen-9-one, ScnS4 | Authors: | Bai, L, Zhou, Y. | Deposit date: | 2021-10-12 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain Acs Catalysis, 12, 2022
|
|
7VO4
| |
8K3U
| S. cerevisiae Chs1 in complex with UDP and GlcNAc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin synthase 1, ... | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-17 | Release date: | 2023-09-06 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3R
| S. cerevisiae Chs1 in apo state incubated with GlcNAc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-16 | Release date: | 2023-08-16 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3W
| S. cerevisiae Chs1 in complex with UDP-GlcNAc and GlcNAc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-17 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3X
| S. cerevisiae Chs1 in complex with Nikkomycin Z | Descriptor: | (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name), Chitin synthase 1 | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-17 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3Q
| S. cerevisiae Chs1 in apo state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-16 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3V
| S. cerevisiae Chs1 in complex with UDP-GlcNAc | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-17 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3T
| S. cerevisiae Chs1 in complex with UDP | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | Authors: | Bai, L, Chen, D. | Deposit date: | 2023-07-17 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
8K3P
| S. cerevisiae Chs1 in complex with polyoxin B | Descriptor: | (2S)-2-[[(2S,3S,4S)-5-aminocarbonyloxy-2-azanyl-3,4-bis(oxidanyl)pentanoyl]amino]-2-[(2R,3S,4R,5R)-5-[5-(hydroxymethyl)-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]ethanoic acid, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | Authors: | Bai, L, Chen, D.D. | Deposit date: | 2023-07-16 | Release date: | 2023-10-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
|
|
6PTJ
| Structure of Ctf4 trimer in complex with one CMG helicase | Descriptor: | Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | Deposit date: | 2019-07-15 | Release date: | 2019-11-20 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
|
|
6PTO
| Structure of Ctf4 trimer in complex with three CMG helicases | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
|
|
6PTN
| Structure of Ctf4 trimer in complex with two CMG helicases | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019
|
|
3HFX
| Crystal structure of carnitine transporter | Descriptor: | CARNITINE, L-carnitine/gamma-butyrobetaine antiporter, MERCURY (II) ION | Authors: | Tang, L, Wang, W.-H, Bai, L, Jiang, T. | Deposit date: | 2009-05-13 | Release date: | 2010-03-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Crystal structure of the carnitine transporter and insights into the antiport mechanism Nat.Struct.Mol.Biol., 17, 2010
|
|
5KZF
| |
6WGI
| Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WGG
| Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WGC
| Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WGF
| Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
4ZRA
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE | Descriptor: | Lipoprotein LprG, Tripalmitoylglycerol | Authors: | Martinot, A.J, Farrow, M, Bai, L, Layre, E, Cheng, T.Y, Tsai, J.H.C, Iqbal, J, Annand, J, Sullivan, Z, Hussain, M, Sacchettini, J, Moody, D.B, Seeliger, J, Rubin, E.J, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2015-05-12 | Release date: | 2016-02-10 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. Plos Pathog., 12, 2016
|
|
3GGR
| Crystal Structure of the Human Rad9-Hus1-Rad1 complex | Descriptor: | Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1 | Authors: | Xu, M, Bai, L, Hang, H.Y, Jiang, T. | Deposit date: | 2009-03-02 | Release date: | 2009-06-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex J.Biol.Chem., 284, 2009
|
|
6U0M
| Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (15-MER), ... | Authors: | Yuan, Z, Georgescu, R, Bai, L, Zhang, D, O'Donnell, M, Li, H. | Deposit date: | 2019-08-14 | Release date: | 2020-03-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nat Commun, 11, 2020
|
|
3OLC
| |
5BK4
| Cryo-EM structure of Mcm2-7 double hexamer on dsDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (60-mer), strand 1, ... | Authors: | Li, H, Yuan, Z, Bai, L. | Deposit date: | 2017-09-12 | Release date: | 2017-10-25 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|