8KFR
 
 | | Crystal structure of ZmMOC1/nicked Holliday junction/Ca2+ complex | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (25-MER), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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3GEQ
 | | Structural basis for the chemical rescue of Src kinase activity | | Descriptor: | 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Muratore, K.E, Seeliger, M.A, Wang, Z, Fomina, D, Neiswinger, J, Havranek, J.J, Baker, D, Kuriyan, J, Cole, P.A. | | Deposit date: | 2009-02-25 | | Release date: | 2009-04-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48, 2009
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8OG1
 | | Exostosin-like 3 apo enzyme | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Sammon, D, Hohenester, E. | | Deposit date: | 2023-03-17 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Molecular mechanism of decision-making in glycosaminoglycan biosynthesis.
Nat Commun, 14, 2023
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8OG4
 | | Exostosin-like 3 UDP complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, MANGANESE (II) ION, ... | | Authors: | Sammon, D, Hohenester, E. | | Deposit date: | 2023-03-18 | | Release date: | 2023-07-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular mechanism of decision-making in glycosaminoglycan biosynthesis.
Nat Commun, 14, 2023
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1ROF
 | | NMR STUDY OF 4FE-4S FERREDOXIN OF THERMATOGA MARITIMA | | Descriptor: | FERREDOXIN, IRON/SULFUR CLUSTER | | Authors: | Roesch, P, Sticht, H, Wildegger, G, Bentrop, D, Darimont, B, Sterner, R. | | Deposit date: | 1995-11-24 | | Release date: | 1996-06-10 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | An NMR-derived model for the solution structure of oxidized Thermotoga maritima 1[Fe4-S4] ferredoxin.
Eur.J.Biochem., 237, 1996
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3G8I
 | | Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes | | Descriptor: | (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor alpha | | Authors: | Benz, J, Bernardeau, A, Binggeli, A, Blum, D, Boehringer, M, Grether, U, Hilpert, H, Kuhn, B, Maerki, H.P, Meyer, M, Puentener, K, Raab, S, Ruf, A, Schlatter, D, Gsell, B, Stihle, M, Mohr, P. | | Deposit date: | 2009-02-12 | | Release date: | 2009-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
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1M5Q
 | | Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum | | Descriptor: | ACETIC ACID, CADMIUM ION, GLYCEROL, ... | | Authors: | Mura, C, Phillips, M, Kozhukhovsky, A, Eisenberg, D. | | Deposit date: | 2002-07-09 | | Release date: | 2003-03-18 | | Last modified: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and assembly of an augmented Sm-like archaeal protein 14-mer
Proc.Natl.Acad.Sci.USA, 100, 2003
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5HIU
 | | Structure of the TSC2 N-terminus | | Descriptor: | GTPase activator-like protein | | Authors: | Zech, R, Kiontke, S, Kummel, D. | | Deposit date: | 2016-01-12 | | Release date: | 2016-08-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
J.Biol.Chem., 291, 2016
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8JT5
 | | VMAT2 complex with histamine | | Descriptor: | HISTAMINE, Synaptic vesicular amine transporter | | Authors: | Jiang, D.H, Wu, D. | | Deposit date: | 2023-06-21 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | VMAT2 complex with histamine
To Be Published
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8JSX
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8JTB
 | | VMAT2 complex with dopamine | | Descriptor: | L-DOPAMINE, Synaptic vesicular amine transporter | | Authors: | Jiang, D.H, Wu, D. | | Deposit date: | 2023-06-21 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | VMAT2 complex with dopamine
To Be Published
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7BYI
 | | Structure of SHMT2 in complex with CBX | | Descriptor: | CARBENOXOLONE, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | | Authors: | Li, L, Chen, Y, Lu, D, Zhang, C, Su, D. | | Deposit date: | 2020-04-23 | | Release date: | 2021-09-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure of SHMT2 with CBX
To Be Published
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3GGP
 | | Crystal structure of prephenate dehydrogenase from A. aeolicus in complex with hydroxyphenyl propionate and NAD+ | | Descriptor: | CHLORIDE ION, HYDROXYPHENYL PROPIONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Sun, W, Shahinas, D, Kimber, M.S, Christendat, D. | | Deposit date: | 2009-03-01 | | Release date: | 2009-03-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The Crystal Structure of Aquifex aeolicus Prephenate Dehydrogenase Reveals the Mode of Tyrosine Inhibition.
J.Biol.Chem., 284, 2009
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8JQU
 | | Crystal structure of GppNHp bound GTPase domain of Rab5a from Leishmania donovani | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | Authors: | Pandey, D, Zohib, M, Pal, R.K, Biswal, B.K, Arora, A. | | Deposit date: | 2023-06-14 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Crystal structure of GppNHp bound GTPase domain of Rab5a from Leishmania donovani
To Be Published
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3G9E
 | | Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes | | Descriptor: | (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | Authors: | Ruf, A, Benz, J, Bernardeau, A, Binggeli, A, Blum, D, Boehringer, M, Grether, U, Hilpert, H, Kuhn, B, Maerki, H.P, Meyer, M, Puenterner, K, Raab, S, Schlatter, D, Gsell, B, Stihle, M, Mohr, P. | | Deposit date: | 2009-02-13 | | Release date: | 2009-06-02 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
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8KFV
 | | Crystal structure of ZmMOC1 K229A in complex with a nicked Holliday junction soaked in Mn2+ for 180 seconds | | Descriptor: | 1,2-ETHANEDIOL, DNA (25-MER), DNA (33-MER), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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8K88
 | | Structure of procaryotic Ago | | Descriptor: | DNA (41-mer), DNA/RNA (21-mer), MAGNESIUM ION, ... | | Authors: | Gao, X, Sun, D, Cui, S, Wang, Y. | | Deposit date: | 2023-07-29 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural Basis of prokaryotic Argonaute System
To Be Published
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8KFT
 | | Crystal structure of ZmMOC1 in complex with a nicked Holliday junction soaked in Mn2+ for 15 seconds | | Descriptor: | DNA (25-MER), DNA (33-MER), DNA (5'-D(P*CP*AP*CP*GP*AP*TP*TP*G)-3'), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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3GGG
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8KFU
 | | Crystal structure of ZmMOC1 in complex with a nicked Holliday junction soaked in Mn2+ for 180 seconds | | Descriptor: | 1,2-ETHANEDIOL, DNA (25-MER), DNA (33-MER), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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8K87
 | | Dimer structure of procaryotic Ago | | Descriptor: | DNA (41-mer), MAGNESIUM ION, Piwi domain protein, ... | | Authors: | Gao, X, Sun, D, Cui, S, Wang, Y. | | Deposit date: | 2023-07-29 | | Release date: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural Basis of prokaryotic Argonaute System
To Be Published
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8KFW
 | | Crystal structure of ZmMOC1 K229A in complex with a nicked Holliday junction soaked in Mn2+ for 600 seconds | | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (33-MER), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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8KFS
 | | Crystal structure of ZmMOC1/nicked Holliday junction complex at ground state | | Descriptor: | DNA (25-MER), DNA (33-MER), DNA (5'-D(P*CP*AP*CP*GP*AP*TP*TP*G)-3'), ... | | Authors: | Zhang, D, Luo, Z, Lin, Z. | | Deposit date: | 2023-08-16 | | Release date: | 2024-06-26 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | MOC1 cleaves Holliday junctions through a cooperative nick and counter-nick mechanism mediated by metal ions.
Nat Commun, 15, 2024
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4DIU
 | | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94 | | Descriptor: | Engineered Protein PF00326 | | Authors: | Seetharaman, J, Lew, S, Wang, D, Kohan, E, Patel, D, Whitehead, T, Fleishman, S, Ciccosanti, C, Xiao, R, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2012-01-31 | | Release date: | 2012-04-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94
To be Published
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8JFC
 | | V1/S quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with compound 6 (B21591), NADPH and dUMP | | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[3-[[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]methyl]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | Authors: | Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Saepua, S, Thongpanchang, C, Yuthavong, Y, Kamchonwongpaisan, S, Hoarau, M. | | Deposit date: | 2023-05-17 | | Release date: | 2023-08-23 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy.
Rsc Med Chem, 14, 2023
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