8DLR

Cryo-EM structure of SARS-CoV-2 Gamma (P.1) spike protein in complex with Fab 4-8 (focused refinement of NTD and 4-8)

Summary for 8DLR

• Entry DOI: 10.2210/pdb8dlr/pdb
• EMDB information: 27512
• Descriptor: Spike glycoprotein, Fab 4-8 heavy chain, Fab 4-8 light chain, ... (4 entities in total)
• Functional Keywords: sars-cov-2, glycoprotein, fusion protein, viral protein, viral protein-immune system complex, gamma, p.1, 4-8
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 3
• Total formula weight: 195774.02

Authors

Zhu, X.,Mannar, D.,Saville, J.W.,Srivastava, S.S.,Berezuk, A.M.,Zhou, S.,Tuttle, K.S.,Subramaniam, S. (deposition date: 2022-07-08, release date: 2022-08-31)

• Primary citation: Mannar, D.,Saville, J.W.,Sun, Z.,Zhu, X.,Marti, M.M.,Srivastava, S.S.,Berezuk, A.M.,Zhou, S.,Tuttle, K.S.,Sobolewski, M.D.,Kim, A.,Treat, B.R.,Da Silva Castanha, P.M.,Jacobs, J.L.,Barratt-Boyes, S.M.,Mellors, J.W.,Dimitrov, D.S.,Li, W.,Subramaniam, S.; SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.; Nat Commun, 13:4696-4696, 2022; PubMed: 35982054; DOI: 10.1038/s41467-022-32262-8

Experimental method

ELECTRON MICROSCOPY (2.51 Å)