6E0N
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![BU of 6e0n by Molmil](/molmil-images/mine/6e0n) | Structure of Elizabethkingia meningoseptica CdnE cyclic dinucleotide synthase with GTP and Apcpp | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. | Deposit date: | 2018-07-06 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
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6VM6
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![BU of 6vm6 by Molmil](/molmil-images/mine/6vm6) | Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor with the cyclic trinucleotide 2'3'3'-cAAA | Descriptor: | 2'-5'-Linked Cyclic RNA (5'-R(P*AP*AP*A)-3'), SAVED domain-containing protein, SULFATE ION | Authors: | Lowey, B, Whiteley, A.T, Keszei, A.F.A, Morehouse, B.R, Antine, S.P, Cabrera, V, Schwede, F, Mekalanos, J.J, Shao, S, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2020-01-27 | Release date: | 2020-06-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell, 182, 2020
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6VM5
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![BU of 6vm5 by Molmil](/molmil-images/mine/6vm5) | Structure of Moraxella osloensis Cap4 SAVED/CARF-domain containing receptor | Descriptor: | MAGNESIUM ION, SAVED domain-containing protein | Authors: | Lowey, B, Whiteley, A.T, Keszei, A.F.A, Morehouse, B.R, Antine, S.P, Cabrera, V, Schwede, F, Mekalanos, J.J, Shao, S, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2020-01-27 | Release date: | 2020-06-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell, 182, 2020
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6WAM
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![BU of 6wam by Molmil](/molmil-images/mine/6wam) | Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor | Descriptor: | SAVED domain-containing protein, SULFATE ION | Authors: | Lowey, B, Whiteley, A.T, Keszei, A.F.A, Morehouse, B.R, Antine, S.P, Cabrera, V, Schwede, F, Mekalanos, J.J, Shao, S, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2020-03-25 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell, 182, 2020
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6WAN
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![BU of 6wan by Molmil](/molmil-images/mine/6wan) | Structure of Acinetobacter baumannii Cap4 SAVED/CARF-domain containing receptor with the cyclic trinucleotide 3'3'3'-cAAA | Descriptor: | Cyclic RNA (R(P*AP*AP*A), SAVED domain-containing protein, SULFATE ION | Authors: | Lowey, B, Whiteley, A.T, Keszei, A.F.A, Morehouse, B.R, Antine, S.P, Cabrera, V, Schwede, F, Mekalanos, J.J, Shao, S, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2020-03-25 | Release date: | 2020-06-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell, 182, 2020
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6M7K
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![BU of 6m7k by Molmil](/molmil-images/mine/6m7k) | Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG) | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C13, cyclic AMP-AMP-GMP | Authors: | Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J. | Deposit date: | 2018-08-20 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567, 2019
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6MYD
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![BU of 6myd by Molmil](/molmil-images/mine/6myd) | Structure of zebrafish TRAF6 in complex with STING CTT | Descriptor: | STING CTT, Transmembrane protein 173, SULFATE ION, ... | Authors: | de Oliveira Mann, C.C, Orzalli, M.H, King, D.S, Kagan, J.C, Lee, A.S.Y, Kranzusch, P.J. | Deposit date: | 2018-11-01 | Release date: | 2019-05-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.399 Å) | Cite: | Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-kappa B Signaling Adaptation. Cell Rep, 27, 2019
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1MNL
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![BU of 1mnl by Molmil](/molmil-images/mine/1mnl) | HIGH-RESOLUTION SOLUTION STRUCTURE OF A SWEET PROTEIN SINGLE-CHAIN MONELLIN (SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DYNAMICAL SIMULATED ANNEALING CALCULATIONS, 21 STRUCTURES | Descriptor: | MONELLIN | Authors: | Lee, S.-Y, Lee, J.-H, Chang, H.-J, Jo, J.-M, Jung, J.-W, Lee, W. | Deposit date: | 1998-08-06 | Release date: | 1999-06-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations. Biochemistry, 38, 1999
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4WYS
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![BU of 4wys by Molmil](/molmil-images/mine/4wys) | Crystal structure of thiolase from Escherichia coli | Descriptor: | Acetyl-CoA acetyltransferase | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2014-11-18 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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4WYR
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![BU of 4wyr by Molmil](/molmil-images/mine/4wyr) | Crystal structure of thiolase mutation (V77Q,N153Y,A286K) from Clostridium acetobutylicum | Descriptor: | Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, GLYCEROL | Authors: | Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J. | Deposit date: | 2014-11-18 | Release date: | 2015-10-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum Nat Commun, 6, 2015
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6TVG
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![BU of 6tvg by Molmil](/molmil-images/mine/6tvg) | |
6TWA
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![BU of 6twa by Molmil](/molmil-images/mine/6twa) | Human CD73 (ecto 5'-nucleotidase) in complex with PSB12646 (an AOPCP derivative, compound 20 in publication) in the closed state | Descriptor: | 5'-nucleotidase, CALCIUM ION, ZINC ION, ... | Authors: | Pippel, J, Strater, N. | Deposit date: | 2020-01-12 | Release date: | 2020-02-19 | Last modified: | 2020-04-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63, 2020
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8DEP
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![BU of 8dep by Molmil](/molmil-images/mine/8dep) | Cryo-EM structure of the human reduced folate carrier, apo condition | Descriptor: | Digitonin, Reduced folate transporter,Soluble cytochrome b562 | Authors: | Wright, N.J, Fedor, J.G, Lee, S.-Y. | Deposit date: | 2022-06-21 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609, 2022
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8YPJ
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![BU of 8ypj by Molmil](/molmil-images/mine/8ypj) | |
9B70
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![BU of 9b70 by Molmil](/molmil-images/mine/9b70) | Cryo-EM structure of MraY in complex with analogue 2 | Descriptor: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-2-[[3-[[[(2~{S})-6-azanyl-2-(hexadecanoylamino)hexanoyl]amino]methyl]phenyl]methylamino]-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propanoic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | Authors: | Hao, A, Lee, S.-Y. | Deposit date: | 2024-03-26 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target. Nat Commun, 15, 2024
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9B71
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![BU of 9b71 by Molmil](/molmil-images/mine/9b71) | Cryo-EM structure of MraY in complex with analogue 3 | Descriptor: | (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]-2-[[4-[[[(2~{S})-5-carbamimidamido-2-(hexadecanoylamino)pentanoyl]amino]methyl]phenyl]methylamino]propanoic acid, MraYAA Nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | Authors: | Hao, A, Lee, S.-Y. | Deposit date: | 2024-03-26 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target. Nat Commun, 15, 2024
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2QR7
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![BU of 2qr7 by Molmil](/molmil-images/mine/2qr7) | |
6S7H
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![BU of 6s7h by Molmil](/molmil-images/mine/6s7h) | Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state | Descriptor: | (N6,N6)-methyl,benzyl-C2-chloro-(alpha,beta)-methylene-ADP, 5'-nucleotidase, CALCIUM ION, ... | Authors: | Pippel, J, Strater, N. | Deposit date: | 2019-07-04 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Adv Ther, 2019
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6S7F
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![BU of 6s7f by Molmil](/molmil-images/mine/6s7f) | |
7BRA
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![BU of 7bra by Molmil](/molmil-images/mine/7bra) | Bacillus subtilis IRG1 | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Bacillus subtilis IRG1, SULFATE ION | Authors: | Park, H.H, Chun, H.L. | Deposit date: | 2020-03-27 | Release date: | 2021-02-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.785 Å) | Cite: | Enzymatic reaction mechanism of cis-aconitate decarboxylase based on the crystal structure of IRG1 from Bacillus subtilis. Sci Rep, 10, 2020
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1ZDM
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![BU of 1zdm by Molmil](/molmil-images/mine/1zdm) | Crystal Structure of Activated CheY Bound to Xe | Descriptor: | Chemotaxis protein cheY, MANGANESE (II) ION, XENON | Authors: | Lowery, T.J, Doucleff, M, Ruiz, E.J, Rubin, S.M, Pines, A, Wemmer, D.E. | Deposit date: | 2005-04-14 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe NMR. Protein Sci., 14, 2005
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1VJS
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![BU of 1vjs by Molmil](/molmil-images/mine/1vjs) | |
7BR9
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![BU of 7br9 by Molmil](/molmil-images/mine/7br9) | Crystal structure of mus musculus IRG1 | Descriptor: | Cis-aconitate decarboxylase | Authors: | Park, H.H, Chun, H.L. | Deposit date: | 2020-03-27 | Release date: | 2021-02-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation. Plos One, 15, 2020
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8Z9B
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![BU of 8z9b by Molmil](/molmil-images/mine/8z9b) | Low molecular weight antigen MTB12 | Descriptor: | Low molecular weight antigen MTB12 | Authors: | Park, H.H, Han, J.H. | Deposit date: | 2024-04-23 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Novel structure of secreted small molecular weight antigen Mtb12 from Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 717, 2024
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8ZEY
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![BU of 8zey by Molmil](/molmil-images/mine/8zey) | Anti-CRISPR type I subtype E3;AcrIE3 | Descriptor: | AcrIE3 | Authors: | Kim, D.Y, Park, H.H. | Deposit date: | 2024-05-07 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.734 Å) | Cite: | Novel structure of the anti-CRISPR protein AcrIE3 and its implication on the CRISPR-Cas inhibition. Biochem.Biophys.Res.Commun., 722, 2024
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