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9DTA
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BU of 9dta by Molmil
Crystal structure of the WDR domain of WDR91 in complex with DR3448
Descriptor: N-(1-benzoyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-(3-cyano-2-methoxyphenyl)acetamide, WD repeat-containing protein 91
Authors:Zeng, H, Ahmad, H, Dong, A, Seitova, A, Counago, R.M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-09-30
Release date:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the WDR domain of WDR91 in complex with DR3448
To be published
9DTB
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BU of 9dtb by Molmil
Crystal structure of the WDR domain of WDR91 in complex with DR3460
Descriptor: N-[(1R)-4-cyano-2,3-dihydro-1H-inden-1-yl]-4-[(quinazolin-4-yl)amino]benzamide, UNKNOWN ATOM OR ION, WD repeat-containing protein 91
Authors:Zeng, H, Ahmad, H, Dong, A, Seitova, A, Counago, R.M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-09-30
Release date:2024-10-16
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of the WDR domain of WDR91 in complex with DR3460
To be published
4MX2
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BU of 4mx2 by Molmil
Crystal Structure of adenylosuccinate lyase from Leishmania donovani
Descriptor: ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, GLYCEROL, ...
Authors:Wernimont, A.K, Loppnau, P, Dong, A, Krojer, T, Bradley, A, Bushell, S, von Delft, F, Robinson, D, Gilbert, I, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, Mottaghi, K, Structural Genomics Consortium (SGC)
Deposit date:2013-09-25
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of adenylosuccinate lyase from Leishmania donovani
To be Published
4PY6
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BU of 4py6 by Molmil
Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum
Descriptor: 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain protein, ...
Authors:Fonseca, M, Tallant, C, Hutchinson, A, Savitsky, P, Krojer, T, Filippakopoulos, P, Loppnau, P, Brennan, P.E, von Delft, F, Dong, A, Josling, G.A, Duffy, M.F, Arrowsmith, C.H, Bountra, C, Hui, R, Knapp, S, Wernimont, A.K, Structural Genomics Consortium (SGC)
Deposit date:2014-03-26
Release date:2014-04-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum
To be Published
4NXJ
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BU of 4nxj by Molmil
Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum
Descriptor: Bromodomain protein
Authors:Wernimont, A.K, Loppnau, P, Knapp, S, Fonseca, M, Brennan, P.E, Dong, A, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, Structural Genomics Consortium (SGC)
Deposit date:2013-12-09
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum
TO BE PUBLISHED
4E74
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BU of 4e74 by Molmil
Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A
Descriptor: Plexin-A4, UNKNOWN ATOM OR ION
Authors:Guan, X, Wang, H, Tempel, W, Dong, A, Tong, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2012-03-16
Release date:2012-03-28
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of the RHO GTPASE BINDING DOMAIN of Plexin A4A
to be published
5U9N
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BU of 5u9n by Molmil
Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine
Descriptor: Bromo domain containing protein, Bromosporine, SULFATE ION
Authors:Hou, C.F.D, Lin, Y.H, Loppnau, P, Hutchinson, A, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC)
Deposit date:2016-12-16
Release date:2017-01-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine
To be published
4HAE
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BU of 4hae by Molmil
Crystal structure of the CDYL2-chromodomain
Descriptor: Chromodomain Y-like protein 2, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Qin, S, Dombrovski, L, Tempel, W, Dong, A, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2012-09-26
Release date:2012-10-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the CDYL2-chromodomain
To be Published
9AVA
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BU of 9ava by Molmil
Co-crystal structure of human TREX1 in complex with an inhibitor
Descriptor: (2R)-2-[(5R,6S,8R,9aS)-8-amino-1-oxo-5-(2-phenylethyl)hexahydro-1H-pyrrolo[1,2-a][1,4]diazepin-2(3H)-yl]-N-[(3,4-dichlorophenyl)methyl]-4-methylpentanamide, POTASSIUM ION, Three-prime repair exonuclease 1, ...
Authors:Dehghani-Tafti, S, Dong, A, Li, Y, Xu, J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-03-01
Release date:2024-05-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Co-crystal structure of human TREX1 in complex with an inhibitor
To be published
9BKS
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BU of 9bks by Molmil
Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Isoform 2 of E3 ubiquitin-protein ligase TRIP12
Authors:Kimani, S, Dong, A, Li, Y, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-04-29
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ADP
To be published
9BKR
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BU of 9bkr by Molmil
Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Isoform 2 of E3 ubiquitin-protein ligase TRIP12, UNKNOWN ATOM OR ION
Authors:Kimani, S, Dong, A, Li, Y, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-04-29
Release date:2024-07-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP
To be published
9CUW
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BU of 9cuw by Molmil
Crystal Structure of SETDB1 Tudor domain in complex with UNC100013
Descriptor: (2E)-4-(dimethylamino)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ...
Authors:Silva, M, Dong, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-07-26
Release date:2024-10-02
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal Structure of SETDB1 Tudor domain in complex with UNC100013
To be published
9CKJ
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BU of 9ckj by Molmil
Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC9512
Descriptor: (3S)-1-[4-(4-methylpiperazin-1-yl)pyridine-2-carbonyl]-N-[(3M)-3-(3-oxo-2,3-dihydro-1H-isoindol-5-yl)phenyl]piperidine-3-carboxamide, TP53-binding protein 1, UNKNOWN ATOM OR ION
Authors:Zeng, H, Dong, A, Shell, D.J, Foley, C, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-07-09
Release date:2024-10-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Co-crystal structure of 53BP1 tandem Tudor domains in complex with UNC9512
To be published
4MTL
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BU of 4mtl by Molmil
Human Methyltransferase-Like Protein 21C
Descriptor: Protein-lysine methyltransferase METTL21C, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
Authors:Hong, B.S, Tempel, W, Dong, A, Li, Y, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-09-19
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Human Methyltransferase-Like Protein 21C
To be Published
4PYZ
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BU of 4pyz by Molmil
Crystal structure of the first two Ubl domains of Deubiquitylase USP7
Descriptor: UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Walker, J.R, Dong, A, Ong, M.S, Dhe-Paganon, S, Kania, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2014-03-28
Release date:2014-04-16
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the first two Ubl domains of Deubiquitylase USP7
to be published
8UWP
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BU of 8uwp by Molmil
Crystal structure of SETDB1 Tudor domain in complex with MR46747
Descriptor: (3S)-N-(4-chloro-3-{[2-(diethylamino)ethyl]carbamoyl}phenyl)-3-(diethylamino)pyrrolidine-1-carboxamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ...
Authors:Shrestha, S, Beldar, S, Dong, A, Ackloo, S, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2023-11-07
Release date:2023-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of SETDB1 Tudor domain in complex with MR46747
To be published
8VL7
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BU of 8vl7 by Molmil
Co-crystal structure of human TREX1 in complex with an inhibitor
Descriptor: (2P)-2-[3-bromo-2-(2-hydroxyethoxy)phenyl]-5-hydroxy-1-methyl-N-(1,2-oxazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Dehghani-Tafti, S, Dong, A, Li, Y, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L.
Deposit date:2024-01-11
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Co-crystal structure of human TREX1 in complex with an inhibitor
To be published
7U9I
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BU of 7u9i by Molmil
Co-crystal structure of human CARM1 in complex with MT556 inhibitor
Descriptor: 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION
Authors:Zeng, H, Perveen, S, Dong, A, Hutchinson, A, Seitova, A, Gibson, E, Hajian, T, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2022-03-10
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Co-crystal structure of human CARM1 in complex with MT556 inhibitor
To Be Published
5VC8
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BU of 5vc8 by Molmil
Crystal structure of the WHSC1 PWWP1 domain
Descriptor: DNA (5'-D(P*CP*TP*(DN))-3'), Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ...
Authors:Qin, S, Tempel, W, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2017-03-31
Release date:2017-06-28
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.
Biochem.Biophys.Res.Commun., 569, 2021
5VS7
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BU of 5vs7 by Molmil
Bromodomain of PF3D7_1475600 from Plasmodium falciparum complexed with peptide H4K5ac
Descriptor: Bromodomain protein, putative, CHLORIDE ION, ...
Authors:Hou, C.F.D, Loppnau, P, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC)
Deposit date:2017-05-11
Release date:2017-05-31
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Bromodomain of PF3D7_1475600 from Plasmodium falciparum complexed with peptide H4K5ac
To be published
5UPD
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BU of 5upd by Molmil
Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
Descriptor: Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ...
Authors:Tempel, W, Yu, W, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2017-02-02
Release date:2017-02-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
To Be Published
8G2I
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BU of 8g2i by Molmil
Crystal Structure of PRMT4 with Compound YD1290
Descriptor: 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine, Histone-arginine methyltransferase CARM1, UNKNOWN ATOM OR ION
Authors:Song, X, Dong, A, Deng, Y, Huang, R, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2023-02-03
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.
Acta Pharm Sin B, 13, 2023
5DWS
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BU of 5dws by Molmil
Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
Descriptor: E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION, txnip
Authors:Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2015-09-22
Release date:2015-10-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
to be published
5DZD
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BU of 5dzd by Molmil
Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
Descriptor: E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2015-09-25
Release date:2015-10-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
To be Published
7UVE
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BU of 7uve by Molmil
Drosophila melanogaster setdb1-tuor domain with peptide H3K9me2K14ac
Descriptor: Histone-lysine N-methyltransferase eggless, peptide H3K9me2K14ac
Authors:Zhou, M, Dong, A, Liu, K, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2022-05-01
Release date:2022-08-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Drosophila melanogaster setdb1-tuor domain with peptide H3K9me2K14ac
To Be Published

229183

數據於2024-12-18公開中

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