7N67
| Crystal structure of HCAN_0198, a 3,4-ketoisomerase from Helicobacter canadensis | Descriptor: | FdtA domain-containing protein, TETRAMETHYLAMMONIUM ION, THYMIDINE-5'-DIPHOSPHATE | Authors: | Heisdorf, C.J, Griffiths, W.A, Thoden, J.B, Holden, H.M. | Deposit date: | 2021-06-07 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis. Protein Sci., 30, 2021
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7N7C
| crystal structure of the N-formyltransferase HCAN_0200 from helicobacter canadensis in complex with folinic acid and dTDP-3-aminoquinovose | Descriptor: | 1,2-ETHANEDIOL, Formyl_trans_N domain-containing protein, N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, ... | Authors: | Heisdorf, C.J, Thoden, J.B, Holden, H.M. | Deposit date: | 2021-06-10 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis. Protein Sci., 30, 2021
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7M15
| crystal structure of cj1430 in the presence of GDP-D-glycero-L-gluco-heptose, a GDP-D-glycero-4-keto-D-lyxo-heptose-3,5-epimerase from campylobacter jejuni | Descriptor: | 1,2-ETHANEDIOL, GDP-D-glycero-L-gluco-heptose, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4R,5R,6S)-6-[(1R)-1,2-dihydroxyethyl]-3,4,5-trihydroxyoxan-2-yl dihydrogen diphosphate (non-preferred name) | Authors: | Girardi, N.M, Thoden, J.B, Raushel, F.M, Holden, H.M. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Biosynthesis of d- glycero -l- gluco -Heptose in the Capsular Polysaccharides of Campylobacter jejuni . Biochemistry, 60, 2021
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7M13
| Crystal structure of CJ1428, a GDP-D-GLYCERO-L-GLUCO-HEPTOSE SYNTHASE from campylobacter jejuni in the presence of NADPH | Descriptor: | 1,2-ETHANEDIOL, GDP-L-fucose synthase, MAGNESIUM ION, ... | Authors: | Anderson, T.K, Thoden, J.B, Raushel, F.M, Holden, H.M. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Biosynthesis of d- glycero -l- gluco -Heptose in the Capsular Polysaccharides of Campylobacter jejuni . Biochemistry, 60, 2021
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7M14
| x-ray structure of cj1430 in the presence of GDP, a GDP-D-glycero-4-keto-D-lyxo-heptose-3,5-epimerase from campylobacter jejuni | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, ... | Authors: | Girardi, N.M, Thoden, J.B, Raushel, F.M, Holden, H.M. | Deposit date: | 2021-03-12 | Release date: | 2021-03-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Biosynthesis of d- glycero -l- gluco -Heptose in the Capsular Polysaccharides of Campylobacter jejuni . Biochemistry, 60, 2021
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7MFO
| X-ray structure of the L136 Aminotransferase from Acanthamoeba polyphaga mimivirus in the presence of TDP and PMP | Descriptor: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CHLORIDE ION, ... | Authors: | Ferek, J.D, Thoden, J.B, Holden, H.M. | Deposit date: | 2021-04-10 | Release date: | 2021-04-28 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus. Protein Sci., 30, 2021
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7MFP
| crystal structure of the L136 aminotransferase K185A from acanthamoeba polyphaga mimivirus in the presence of the UDP-viosamine external aldimine | Descriptor: | (2R,3R,4S,5S,6R)-3,4-dihydroxy-5-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-6-methyloxan-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (non-preferred name), 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Seltzner, C.A, Thoden, J.B, Holden, H.M. | Deposit date: | 2021-04-10 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus. Protein Sci., 30, 2021
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7MFQ
| crystal structure of the L136 aminotransferase from acanthamoeba polyphaga mimivirus in complex with the TDP-viosamine external aldimine | Descriptor: | (2R,3R,4S,5S,6R)-3,4-DIHYDROXY-5-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)IMINO]-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL [(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Seltzner, C.A, Thoden, J.B, Holden, H.M. | Deposit date: | 2021-04-10 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus. Protein Sci., 30, 2021
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1KEE
| Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ... | Authors: | Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M. | Deposit date: | 2001-11-15 | Release date: | 2001-12-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. J.Biol.Chem., 277, 2002
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1A9X
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1XEL
| UDP-GALACTOSE 4-EPIMERASE FROM ESCHERICHIA COLI | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Thoden, J, Holden, H. | Deposit date: | 1996-01-25 | Release date: | 1997-02-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism. Biochemistry, 35, 1996
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1JXZ
| Structure of the H90Q mutant of 4-Chlorobenzoyl-Coenzyme A Dehalogenase complexed with 4-hydroxybenzoyl-Coenzyme A (product) | Descriptor: | 4-HYDROXYBENZOYL COENZYME A, 4-chlorobenzoyl Coenzyme A dehalogenase, CALCIUM ION, ... | Authors: | Thoden, J.B, Zhang, W, Wei, Y, Luo, L, Taylor, K.L, Yang, G, Dunaway-Mariano, D, Benning, M.M, Holden, H.M. | Deposit date: | 2001-09-10 | Release date: | 2001-10-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Histidine 90 Function in 4-chlorobenzoyl-coenzyme A Dehalogenase Catalysis Biochemistry, 40, 2001
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1MUH
| CRYSTAL STRUCTURE OF TN5 TRANSPOSASE COMPLEXED WITH TRANSPOSON END DNA | Descriptor: | DNA NON-TRANSFERRED STRAND, DNA TRANSFERRED STRAND, MAGNESIUM ION, ... | Authors: | Thoden, J.B, Holden, H.M, Davies, D.R, Goryshin, I.Y, Reznikoff, W.S, Rayment, I. | Deposit date: | 2002-09-23 | Release date: | 2002-09-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science, 289, 2000
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1VOM
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3FSB
| Crystal structure of QdtC, the dTDP-3-amino-3,6-dideoxy-D-glucose N-acetyl transferase from Thermoanaerobacterium thermosaccharolyticum in complex with CoA and dTDP-3-amino-quinovose | Descriptor: | COENZYME A, QdtC, [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate | Authors: | Holden, H.M, Thoden, J.B. | Deposit date: | 2009-01-09 | Release date: | 2009-02-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Functional Studies of QdtC: an N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-Dideoxy-alpha-D-Glucose. Biochemistry, 48, 2009
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3FSC
| Crystal structure of QdtC, the dTDP-3-amino-3,6-dideoxy-D-glucose N-acetyl transferase from Thermoanaerobacterium thermosaccharolyticum in complex with CoA and dTDP-3-amino-fucose | Descriptor: | (3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate, COENZYME A, QdtC | Authors: | Holden, H.M, Thoden, J.B. | Deposit date: | 2009-01-09 | Release date: | 2009-02-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Functional Studies of QdtC: an N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-Dideoxy-alpha-D-Glucose. Biochemistry, 48, 2009
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3FS8
| Crystal structure of QdtC, the dTDP-3-amino-3,6-dideoxy-D-glucose N-acetyl transferase from Thermoanaerobacterium thermosaccharolyticum in complex with Acetyl-CoA | Descriptor: | ACETYL COENZYME *A, QdtC, THYMINE | Authors: | Holden, H.M, Thoden, J.B. | Deposit date: | 2009-01-09 | Release date: | 2009-02-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Studies of QdtC: an N-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-Dideoxy-alpha-D-Glucose. Biochemistry, 48, 2009
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4I3G
| Crystal Structure of DesR, a beta-glucosidase from Streptomyces venezuelae in complex with D-glucose. | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Beta-glucosidase, ... | Authors: | Zmudka, M.W, Holden, H.M. | Deposit date: | 2012-11-26 | Release date: | 2013-02-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The structure of DesR from Streptomyces venezuelae, a beta-glucosidase involved in macrolide activation. Protein Sci., 22, 2013
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2OGE
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2OGA
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6B5K
| Mycobacterium tuberculosis RmlA in complex with Mg/dTTP | Descriptor: | 1,2-ETHANEDIOL, Glucose-1-phosphate thymidylyltransferase, MAGNESIUM ION, ... | Authors: | Brown, H.A, Holden, H.A. | Deposit date: | 2017-09-29 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Protein Sci., 27, 2018
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6B5E
| Mycobacterium tuberculosis RmlA in complex with dTDP-glucose | Descriptor: | 1,2-ETHANEDIOL, 2'DEOXY-THYMIDINE-5'-DIPHOSPHO-ALPHA-D-GLUCOSE, CHLORIDE ION, ... | Authors: | Brown, H.A, Holden, H.M. | Deposit date: | 2017-09-29 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Protein Sci., 27, 2018
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1QOB
| FERREDOXIN MUTATION D62K | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN, SULFATE ION | Authors: | Holden, H.M, Benning, M.M. | Deposit date: | 1997-08-14 | Release date: | 1998-01-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry, 36, 1997
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1QOF
| FERREDOXIN MUTATION Q70K | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN, SULFATE ION | Authors: | Holden, H.M, Benning, M.M. | Deposit date: | 1997-08-14 | Release date: | 1998-01-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry, 36, 1997
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1QOG
| FERREDOXIN MUTATION S47A | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN, SULFATE ION | Authors: | Holden, H.M, Benning, M.M. | Deposit date: | 1997-08-14 | Release date: | 1998-01-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry, 36, 1997
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