8JJB
 
 | | Crystal structure of T2R-TTL-Y61 complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Yang, J. | | Deposit date: | 2023-05-30 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.
Eur.J.Med.Chem., 268, 2024
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8JJC
 | | Tubulin-Y62 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(6,7-dimethoxy-3,4-dihydro-1~{H}-isoquinolin-2-yl)-6-(3-methoxyphenyl)pyrimidin-2-amine, CALCIUM ION, ... | | Authors: | Yang, J. | | Deposit date: | 2023-05-30 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.
Eur.J.Med.Chem., 268, 2024
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8XQF
 | | Cryo-EM structure of human monomeric APJR-Gi complex with apelin-13. | | Descriptor: | Apelin-13, G protein subunit alpha i1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-01-05 | | Release date: | 2025-01-22 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8XQE
 | | Cryo-EM structure of human dimeric APJR-Gi complex with apelin-13. | | Descriptor: | Apelin-13, G protein subunit alpha i1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-01-05 | | Release date: | 2025-01-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8XQI
 | | Cryo-EM structure of human dimeric Apelin receptor. | | Descriptor: | CHOLESTEROL, Soluble cytochrome b562,Apelin receptor | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-01-05 | | Release date: | 2025-01-22 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8XQJ
 | | Cryo-EM structure of human dimeric APJR complex with antagonistic antibody | | Descriptor: | CHOLESTEROL, JN241, Soluble cytochrome b562,Apelin receptor | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-01-05 | | Release date: | 2025-01-22 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8Z7J
 | | Cryo-EM structure of APJR-Gi complex with agonistic antibody | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-04-20 | | Release date: | 2025-01-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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8Z74
 | | Cryo-EM structure of APJR complex with agonistic antibody | | Descriptor: | CHOLESTEROL, Soluble cytochrome b562,Apelin receptor, agonistic antibody | | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F. | | Deposit date: | 2024-04-19 | | Release date: | 2025-01-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structural insights into the regulation of monomeric and dimeric apelin receptor.
Nat Commun, 16, 2025
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7XYA
 | | The cryo-EM structure of an AlpA-loading complex | | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wen, A, Feng, Y. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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7WCY
 | | Crystal Structure of H-2Kb with Cryptosporidium parvum gp40/15 epitope | | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Wang, Y.L, Gao, M.H, Zhang, L.X, Fan, S.H. | | Deposit date: | 2021-12-20 | | Release date: | 2022-12-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural Analyses of a Dominant Cryptosporidium parvum Epitope Presented by H-2K b Offer New Options To Combat Cryptosporidiosis.
Mbio, 14, 2023
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7CLD
 | | Crystal structure of T2R-TTL-Cevipabulin complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ... | | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | Deposit date: | 2020-07-20 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.611 Å) | | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
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7CLF
 | | PigF with SAH | | Descriptor: | ACETATE ION, Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | | Deposit date: | 2020-07-20 | | Release date: | 2021-07-28 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.982 Å) | | Cite: | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism.
Iucrj, 9, 2022
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7CLU
 | | PigF with SAH | | Descriptor: | ACETATE ION, GLYCEROL, Methyltransferase domain-containing protein | | Authors: | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | | Deposit date: | 2020-07-22 | | Release date: | 2021-07-28 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism.
Iucrj, 9, 2022
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7DP8
 | | Crystal structure of T2R-TTL-Cevipabulin-eribulin complex | | Descriptor: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... | | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | Deposit date: | 2020-12-18 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.446 Å) | | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
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8YLD
 | | State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-03-06 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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8YLR
 | | State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-03-06 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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8Z70
 | | State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-04-19 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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8Z71
 | | State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-04-19 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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8XU8
 | | State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation | | Descriptor: | 18S rRNA, 25S rRNA, 5.8S rRNA, ... | | Authors: | Cheng, J, Wu, C.L, Li, J.X, Zhang, X.Z. | | Deposit date: | 2024-01-12 | | Release date: | 2024-12-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Capturing eukaryotic ribosome dynamics in situ at high resolution.
Nat.Struct.Mol.Biol., 32, 2025
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7VWP
 | | Structure of the flavin-dependent monooxygenase FlsO1 from the biosynthesis of fluostatinsin | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FlsO1, PHOSPHATE ION, ... | | Authors: | Zhang, Y, Yang, C, Zhang, L, Zhang, C. | | Deposit date: | 2021-11-11 | | Release date: | 2022-09-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation
Nat Commun, 13, 2022
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7XYB
 | | The cryo-EM structure of an AlpA-loaded complex | | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wen, A, Feng, Y. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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8TNJ
 | | Cryo-EM structure of HLA-B*73:01 bound to a 9mer peptide and two Fabs | | Descriptor: | 9mer peptide,Beta-2-microglobulin,MHC class I antigen chimera, B.1 Fab heavy chain, B.1 Fab light chain, ... | | Authors: | Ross, P, Adams, E.J, Lodwick, J, Zhao, M, Slezak, T, Kossiakoff, A. | | Deposit date: | 2023-08-02 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of HLA-B*73:01 bound to a 9mer peptide and two Fabs
To Be Published
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