7TEO
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![BU of 7teo by Molmil](/molmil-images/mine/7teo) | Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle in complex with FUB1 | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | Authors: | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | Deposit date: | 2022-01-05 | Release date: | 2022-08-10 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat.Struct.Mol.Biol., 29, 2022
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7TEJ
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![BU of 7tej by Molmil](/molmil-images/mine/7tej) | Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle | Descriptor: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | Authors: | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | Deposit date: | 2022-01-05 | Release date: | 2022-08-10 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat.Struct.Mol.Biol., 29, 2022
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5I4V
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![BU of 5i4v by Molmil](/molmil-images/mine/5i4v) | Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | Descriptor: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | Authors: | Chen, G, McKeever, B.M. | Deposit date: | 2016-02-12 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
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5WE2
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![BU of 5we2 by Molmil](/molmil-images/mine/5we2) | Structural Basis for Telomere Length Regulation by the Shelterin Bridge | Descriptor: | DNA-binding protein rap1, Protection of telomeres protein poz1, Protection of telomeres protein tpz1, ... | Authors: | Kim, J.-K, Liu, J, Hu, X, Sankaran, B, Qiao, F. | Deposit date: | 2017-07-06 | Release date: | 2017-12-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Shelterin Bridge Assembly. Mol. Cell, 68, 2017
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3DIM
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3DJ2
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![BU of 3dj2 by Molmil](/molmil-images/mine/3dj2) | |
7XDI
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![BU of 7xdi by Molmil](/molmil-images/mine/7xdi) | Tail structure of bacteriophage SSV19 | Descriptor: | B210, C131, VP1, ... | Authors: | Liu, H.R, Chen, W.Y. | Deposit date: | 2022-03-27 | Release date: | 2022-08-10 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail. Proc.Natl.Acad.Sci.USA, 119, 2022
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3DIO
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5FAD
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![BU of 5fad by Molmil](/molmil-images/mine/5fad) | SAH complex with aKMT from the hyperthermophilic archaeon Sulfolobus islandicus | Descriptor: | MAGNESIUM ION, Ribosomal protein L11 methyltransferase, putative, ... | Authors: | Ouyang, S. | Deposit date: | 2015-12-11 | Release date: | 2016-06-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism Mol.Cell Proteomics, 15, 2016
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5FA8
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![BU of 5fa8 by Molmil](/molmil-images/mine/5fa8) | SAM complex with aKMT from the hyperthermophilic archaeon Sulfolobus islandicu | Descriptor: | MAGNESIUM ION, Ribosomal protein L11 methyltransferase, putative, ... | Authors: | Ouyang, S. | Deposit date: | 2015-12-11 | Release date: | 2016-06-29 | Last modified: | 2016-09-14 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism Mol.Cell Proteomics, 15, 2016
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7M4T
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![BU of 7m4t by Molmil](/molmil-images/mine/7m4t) | Menin bound to M-1121 | Descriptor: | Menin, methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate, praseodymium triacetate | Authors: | Stuckey, J. | Deposit date: | 2021-03-22 | Release date: | 2021-08-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression. J.Med.Chem., 64, 2021
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3DIZ
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3DIQ
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7MCE
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![BU of 7mce by Molmil](/molmil-images/mine/7mce) | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol | Descriptor: | 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol, Bromodomain-containing protein 4 | Authors: | Sheriff, S. | Deposit date: | 2021-04-02 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg.Med.Chem.Lett., 51, 2021
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3DIG
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3DIX
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3DIR
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![BU of 3dir by Molmil](/molmil-images/mine/3dir) | |
3DIL
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![BU of 3dil by Molmil](/molmil-images/mine/3dil) | |
3DJ0
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3DIS
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3DIY
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3F57
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3H1J
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![BU of 3h1j by Molmil](/molmil-images/mine/3h1j) | Stigmatellin-bound cytochrome bc1 complex from chicken | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, Coenzyme Q10, ... | Authors: | Zhang, Z, Huang, L, Shulmeister, V.M, Chi, Y.-I, Kim, K.K, Hung, L.-W, Crofts, A.R, Berry, E.A, Kim, S.-H. | Deposit date: | 2009-04-12 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Electron Transfer by Domain Movement in Cytochrome Bc1 Nature, 392, 1998
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3ON9
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![BU of 3on9 by Molmil](/molmil-images/mine/3on9) | The SECRET domain from Ectromelia virus | Descriptor: | Tumour necrosis factor receptor | Authors: | Wang, X.Q, Xue, X.G, Wang, D.L. | Deposit date: | 2010-08-28 | Release date: | 2011-08-17 | Last modified: | 2013-06-26 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor Plos Pathog., 7, 2011
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3ONA
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![BU of 3ona by Molmil](/molmil-images/mine/3ona) | The SECRET domain in complex with CX3CL1 | Descriptor: | CX3CL1 protein, Tumour necrosis factor receptor | Authors: | Wang, X.Q, Xue, X.G, Wang, D.L. | Deposit date: | 2010-08-28 | Release date: | 2011-08-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor Plos Pathog., 7, 2011
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