8WX0
| PNPase of M.tuberculosis with its RNA substrate | Descriptor: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase, RNA (24-mer) | Authors: | Wang, N, Sheng, Y.N. | Deposit date: | 2023-10-27 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation. Arch.Biochem.Biophys., 754, 2024
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8X73
| Crystal structure of Peroxiredoxin I in complex with compound 19-069 | Descriptor: | Peroxiredoxin-1, methyl (2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]-3-oxidanyl-propanoate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8WXF
| PNPase of Mycobacterium tuberculosis | Descriptor: | Bifunctional guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase | Authors: | Wang, N, Sheng, Y.N, Liu, Y.T. | Deposit date: | 2023-10-29 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of Mycobacterium tuberculosis polynucleotide phosphorylase suggest a potential mechanism for its RNA substrate degradation. Arch.Biochem.Biophys., 754, 2024
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8HMF
| head module state 2 of Tetrahymena IFT-A | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | Authors: | Ma, Y, Wu, J, Lei, M. | Deposit date: | 2022-12-03 | Release date: | 2023-06-14 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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8X71
| Crystal structure of Peroxiredoxin I in complex with compound 19-064 | Descriptor: | Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate | Authors: | Zhang, H, Luo, C. | Deposit date: | 2023-11-22 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. J.Med.Chem., 67, 2024
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8IOW
| Cryo-EM structure of the sarilumab Fab/IL-6R complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Sarilumab Fab, Interleukin-6 receptor subunit alpha, ... | Authors: | She, J, Chen, L, Wang, M.X. | Deposit date: | 2023-03-13 | Release date: | 2024-03-20 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into IL-6 signaling inhibition by therapeutic antibodies. Cell Rep, 43, 2024
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4FGX
| Crystal structure of bace1 with novel inhibitor | Descriptor: | Beta-secretase 1, DI(HYDROXYETHYL)ETHER, Inhibitor (2R,5S,8S,12S,13S,16S,19S,22S)-16-(3-amino-3-oxopropyl)-2,13-dibenzyl-12,22-dihydroxy-8-isobutyl-19-isopropyl-3,5,17-trimethyl-4,7,10,15,18,21-hexaoxo-3,6,9,14,17,20-hexaazatricosan-1-oic acid, ... | Authors: | Chen, T.T, Chen, W.Y, Li, L, Xu, Y.C. | Deposit date: | 2012-06-05 | Release date: | 2013-01-16 | Last modified: | 2021-09-15 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
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6KKI
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5EAJ
| Crystal structure of DHFR in 0% Isopropanol | Descriptor: | CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... | Authors: | Cuneo, M.J, Agarwal, P.K. | Deposit date: | 2015-10-16 | Release date: | 2016-09-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Modulating Enzyme Activity by Altering Protein Dynamics with Solvent. Biochemistry, 57, 2018
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6KKK
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6KKJ
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5XKD
| Crystal structure of dibenzothiophene sulfone monooxygenase BdsA in complex with FMN at 2.4 angstrom | Descriptor: | Dibenzothiophene desulfurization enzyme A, FLAVIN MONONUCLEOTIDE | Authors: | Gu, L, Su, T, Liu, S, Su, J. | Deposit date: | 2017-05-07 | Release date: | 2018-05-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the "4S" Desulfurization Pathway. Front Microbiol, 9, 2018
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8IHO
| Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors | Descriptor: | Papain-like protease nsp3, ZINC ION, covalent inhibitor | Authors: | Wang, Q, Hu, H, Li, M, Xu, Y. | Deposit date: | 2023-02-23 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease. Int J Mol Sci, 24, 2023
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5XKC
| Crystal structure of dibenzothiophene sulfone monooxygenase BdsA at 2.2 angstrome | Descriptor: | Dibenzothiophene desulfurization enzyme A | Authors: | Gu, L, Su, T, Liu, S, Su, J. | Deposit date: | 2017-05-07 | Release date: | 2018-05-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.209 Å) | Cite: | Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the "4S" Desulfurization Pathway. Front Microbiol, 9, 2018
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4PPM
| Crystal structure of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 | Descriptor: | Aminotransferase, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE | Authors: | Lou, X.D, Ran, T.T, Xu, D.Q, Wang, W.W. | Deposit date: | 2014-02-27 | Release date: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the catalytic domain of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 Biochem.Biophys.Res.Commun., 447, 2014
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7W0D
| Dicer2-LoqsPD-dsRNA complex at mid-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0C
| Dicer2-Loqs-PD-dsRNA complex at early-translocation state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0E
| dmDicer2-LoqsPD-dsRNA Active-dicing status | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0B
| Dicer2-LoqsPD complex at apo status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0F
| dmDicer2-LoqsPD-dsRNA Post-dicing status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0A
| dmDicer2-LoqsPD-dsRNA Dimer status | Descriptor: | Dicer-2, isoform A, Loquacious, ... | Authors: | Su, S, Wang, J, Wang, H.W, Ma, J. | Deposit date: | 2021-11-18 | Release date: | 2022-04-27 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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4P1J
| Crystal structure of wild type Hypocrea jecorina Cel7a in a hexagonal crystal form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Exoglucanase 1, SAMARIUM (III) ION, ... | Authors: | Bodenheimer, A.B, Cuneo, M.J, Swartz, P.D, Myles, D.A, Meilleur, F. | Deposit date: | 2014-02-26 | Release date: | 2015-03-25 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Crystal structure of wild type Hypocrea jecorina Cel7a in a hexagonal crystal form To Be Published
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7BZB
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7BZC
| Crystal structure of plant sesterterpene synthase AtTPS18 complexed with farnesyl thiolodiphosphate (FSPP) | Descriptor: | MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Terpenoid synthase 18 | Authors: | Li, J.X, Wang, G.D, Zhang, P. | Deposit date: | 2020-04-27 | Release date: | 2020-09-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases. Plant Commun., 1, 2020
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2LKH
| WSA minor conformation | Descriptor: | Acetylcholine receptor | Authors: | Xu, Y, Mowrey, D, Cui, T, Perez-Aguilar, J, Saven, J.G, Eckenhoff, R, Tang, P. | Deposit date: | 2011-10-11 | Release date: | 2012-01-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim.Biophys.Acta, 1818, 2011
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