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6I1R
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BU of 6i1r by Molmil
Crystal structure of CMP bound CST in an outward facing conformation
Descriptor: CMP-sialic acid transporter 1, CYTIDINE-5'-MONOPHOSPHATE
Authors:Nji, E, Gulati, A, Qureshi, A.A, Drew, D.
Deposit date:2018-10-30
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the delivery of activated sialic acid into Golgi for sialyation.
Nat.Struct.Mol.Biol., 26, 2019
6I1Z
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BU of 6i1z by Molmil
Outward facing structure of apo CST
Descriptor: CMP-sialic acid transporter 1
Authors:Nji, E, Gulati, A, Qureshi, A.A, Drew, D.
Deposit date:2018-10-31
Release date:2019-06-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for the delivery of activated sialic acid into Golgi for sialyation.
Nat.Struct.Mol.Biol., 26, 2019
6SSR
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BU of 6ssr by Molmil
Crystal structure of Human Microsomal Glutathione S-Transferase 2 at 3.8 Angstroms resolution
Descriptor: Microsomal glutathione S-transferase 2
Authors:Thulasingam, M, Nji, E, Rinaldo-Matthis, A, Haeggstrom, J.Z.
Deposit date:2019-09-09
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
6SSS
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BU of 6sss by Molmil
Crystal structure of Human Microsomal Glutathione S-Transferase 2
Descriptor: 1-(8Z-hexadecenoyl)-sn-glycerol, GLYCEROL, Microsomal glutathione S-transferase 2, ...
Authors:Thulasingam, M, Nji, E, Haeggstrom, J.Z.
Deposit date:2019-09-09
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
5BZ3
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BU of 5bz3 by Molmil
CRYSTAL STRUCTURE OF SODIUM PROTON ANTIPORTER NAPA IN OUTWARD-FACING CONFORMATION.
Descriptor: (2R)-2,3-DIHYDROXYPROPYL (7Z)-TETRADEC-7-ENOATE, Na(+)/H(+) antiporter
Authors:Coincon, M, Uzdavinys, P, Emmanuel, N, Cameron, A, Drew, D.
Deposit date:2015-06-11
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters.
Nat.Struct.Mol.Biol., 23, 2016
7OIX
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BU of 7oix by Molmil
Structure of thermostable human MFSD2A in complex with thermostable human Sync2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Sodium-dependent lysophosphatidylcholine symporter 1, Syncytin-2, ...
Authors:Martinez-Molledo, M, Reyes, N.
Deposit date:2021-05-12
Release date:2022-06-01
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2.
Nat.Struct.Mol.Biol., 29, 2022
5BZ2
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BU of 5bz2 by Molmil
CRYSTAL STRUCTURE OF THE SODIUM PROTON ANTIPORTER NAPA IN INWARD-FACING CONFORMATION
Descriptor: Na(+)/H(+) antiporter
Authors:Coincon, M, Uzdavinys, P, Cameron, A, Drew, D.
Deposit date:2015-06-11
Release date:2016-01-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters.
Nat.Struct.Mol.Biol., 23, 2016
6RW3
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BU of 6rw3 by Molmil
The molecular basis for sugar import in malaria parasites.
Descriptor: Hexose transporter 1, alpha-D-glucopyranose, beta-D-glucopyranose
Authors:Qureshi, A, Matsuoka, R, Brock, J, Drew, D.
Deposit date:2019-06-03
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:The molecular basis for sugar import in malaria parasites.
Nature, 578, 2020
6SSW
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BU of 6ssw by Molmil
Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with an Inhibitor Glutathione sulfonic acid
Descriptor: GLUTATHIONE SULFONIC ACID, Microsomal glutathione S-transferase 2
Authors:Thulasingam, M, Haeggstrom, J.Z.
Deposit date:2019-09-09
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
6SSU
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BU of 6ssu by Molmil
Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with co-substrate Glutathione
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLUTATHIONE, Microsomal glutathione S-transferase 2, ...
Authors:Thulasingam, M, Haeggstrom, J.Z.
Deposit date:2019-09-09
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.
Nat Commun, 12, 2021
7WXX
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BU of 7wxx by Molmil
Crystal structure of human MMP-7 in complex with inhibitor
Descriptor: CALCIUM ION, Matrilysin, Peptide Inhibitor, ...
Authors:Kamitani, M, Oka, Y, Tabuse, H.
Deposit date:2022-02-15
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides.
J.Med.Chem., 65, 2022
8JUF
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BU of 8juf by Molmil
Crystal structure of human MMP-7 in complex with inhibitor
Descriptor: CALCIUM ION, Matrilysin, Peptide Inhibitor, ...
Authors:Kamitani, M, Abe-Sato, K, Oka, Y.
Deposit date:2023-06-26
Release date:2023-11-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.
J.Med.Chem., 66, 2023
8JUD
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BU of 8jud by Molmil
Crystal structure of human MMP-7 in complex with inhibitor
Descriptor: CALCIUM ION, Matrilysin, Peptide Inhibitor, ...
Authors:Kamitani, M, Abe-Sato, K, Oka, Y.
Deposit date:2023-06-26
Release date:2023-11-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.
J.Med.Chem., 66, 2023
8JUG
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BU of 8jug by Molmil
Crystal structure of human MMP-7 in complex with inhibitor
Descriptor: CALCIUM ION, Matrilysin, Peptide Inhibitor, ...
Authors:Kamitani, M, Abe-Sato, K, Oka, Y.
Deposit date:2023-06-26
Release date:2023-11-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis.
J.Med.Chem., 66, 2023
8K4Z
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BU of 8k4z by Molmil
Crystal structure of human MMP-7 in complex with inhibitor
Descriptor: CALCIUM ION, CHLORIDE ION, IODIDE ION, ...
Authors:Kamitani, M, Mima, M, Oka, Y.
Deposit date:2023-07-20
Release date:2024-04-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of TP0628103: A Selective MMP-7 Inhibitor Based on the Mitigation of OATP Substrate Recognition through Isoelectric Point Shift Strategy
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数据于2024-11-06公开中

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