7OIX

Structure of thermostable human MFSD2A in complex with thermostable human Sync2

Summary for 7OIX

Entry DOI	10.2210/pdb7oix/pdb
EMDB information	12935
Descriptor	Syncytin-2, Isoform 2 of Sodium-dependent lysophosphatidylcholine symporter 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	human membrane protein, mfs transporter, human endogenous retroviral protein, syncytin, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	121405.99
Authors	Martinez-Molledo, M.,Reyes, N. (deposition date: 2021-05-12, release date: 2022-06-01, Last modification date: 2022-06-29)
Primary citation	Martinez-Molledo, M.,Nji, E.,Reyes, N. Structural insights into the lysophospholipid brain uptake mechanism and its inhibition by syncytin-2. Nat.Struct.Mol.Biol., 29:604-612, 2022 Cited by PubMed: 35710838 DOI: 10.1038/s41594-022-00786-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation