7OIX
Structure of thermostable human MFSD2A in complex with thermostable human Sync2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Syncytin-2 | polymer | 538 | 59613.2 | 1 | UniProt (P60508) Pfam (PF00429) | Homo sapiens (human) | Endogenous retrovirus group FRD member 1,Envelope polyprotein,HERV-FRD,HERV-FRD_6p24.1 provirus ancestral Env polyprotein |
| 2 | B (B) | Isoform 2 of Sodium-dependent lysophosphatidylcholine symporter 1 | polymer | 530 | 58540.8 | 1 | UniProt (Q8NA29) Pfam (PF13347) | Homo sapiens (human) | NLS1,Sodium-dependent LPC symporter 1,Major facilitator superfamily domain-containing protein 2A |
| 3 | C (C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB | |||
| 4 | D (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G23799GS) | |||
| 5 | E, F, G, H, I (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
A: 1 - 538 (UniProt: P60508)
B: 1 - 530 (UniProt: Q8NA29)
| PDB | External Database | Details |
|---|---|---|
| Thr 128 | Met 128 | conflict |
| Pro 153 | Ser 153 | conflict |
| Thr 190 | Ser 190 | conflict |
| Phe 486 | Leu 486 | conflict |
| Ile 487 | Thr 487 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 43 | Val 43 | conflict |
| Val 51 | Leu 51 | conflict |
| Phe 102 | Leu 102 | conflict |
| Ser 108 | Pro 108 | conflict |
| Arg 111 | Cys 111 | conflict |
| Leu 157 | Met 157 | conflict |
| Ser 177 | Thr 177 | conflict |
| Asn 240 | Lys 240 | conflict |
| Ala 250 | Val 250 | conflict |
| Ser 251 | Cys 251 | conflict |
| Val 254 | Ile 254 | conflict |
| Thr 261 | Ile 261 | conflict |
| Met 279 | Ile 279 | conflict |
| Ser 280 | Ala 280 | conflict |
| Phe 281 | Tyr 281 | conflict |
| Ala 299 | Thr 299 | conflict |
| Ala 316 | Val 316 | conflict |
| Val 383 | Ile 383 | conflict |
| Val 386 | Ala 386 | conflict |
| Ser 420 | Phe 420 | conflict |
| Lys 471 | Asn 471 | conflict |
| Leu 491 | Met 491 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118154.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2145.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 121406.0 |
