5B2L
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![BU of 5b2l by Molmil](/molmil-images/mine/5b2l) | A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Dual specificity mitogen-activated protein kinase kinase 7, GLYCEROL | Authors: | Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T. | Deposit date: | 2016-01-19 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Biochem.Biophys.Res.Commun., 473, 2016
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5B2K
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![BU of 5b2k by Molmil](/molmil-images/mine/5b2k) | A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7 | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7 | Authors: | Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T. | Deposit date: | 2016-01-19 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Biochem.Biophys.Res.Commun., 473, 2016
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5B2M
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![BU of 5b2m by Molmil](/molmil-images/mine/5b2m) | A crucial role of Cys218 in the stabilization of an unprecedented auto-inhibition form of MAP2K7 | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 7 | Authors: | Sogabe, Y, Hashimoto, T, Matsumoto, T, Kirii, Y, Sawa, M, Kinoshita, T. | Deposit date: | 2016-01-19 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Biochem.Biophys.Res.Commun., 473, 2016
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3VN9
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![BU of 3vn9 by Molmil](/molmil-images/mine/3vn9) | Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state | Descriptor: | 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine, Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION | Authors: | Kinoshita, T, Matsuzaka, H, Nakai, R, Kirii, Y, Yokota, K, Tada, T, Matsumoto, T. | Deposit date: | 2012-01-05 | Release date: | 2012-02-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state J.Biochem., 151, 2012
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3VUT
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![BU of 3vut by Molmil](/molmil-images/mine/3vut) | Crystal structures of non-phosphorylated MAP2K4 | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 4 | Authors: | Matsumoto, T, Kinoshita, T, Kirii, Y, Tada, T, Yamano, A. | Deposit date: | 2012-07-05 | Release date: | 2012-09-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal and solution structures disclose a putative transient state of mitogen-activated protein kinase kinase 4 Biochem.Biophys.Res.Commun., 425, 2012
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3ALN
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![BU of 3aln by Molmil](/molmil-images/mine/3aln) | Crystal Structure of human non-phosphorylated MKK4 kinase domain complexed with AMP-PNP | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Matsumoto, T, Kinoshita, T, Kirii, Y, Yokota, K, Hamada, K, Tada, T. | Deposit date: | 2010-08-04 | Release date: | 2010-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Biochem.Biophys.Res.Commun., 400, 2010
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3ALO
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![BU of 3alo by Molmil](/molmil-images/mine/3alo) | Crystal structure of human non-phosphorylated MKK4 kinase domain ternary complex with AMP-PNP and p38 peptide | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Matsumoto, T, Kinoshita, T, Kirii, Y, Yokota, K, Hamada, K, Tada, T. | Deposit date: | 2010-08-04 | Release date: | 2010-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Biochem.Biophys.Res.Commun., 400, 2010
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3WZU
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![BU of 3wzu by Molmil](/molmil-images/mine/3wzu) | THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol | Descriptor: | (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, Dual specificity mitogen-activated protein kinase kinase 7 | Authors: | Sogabe, Y, Hashimoto, Y, Matsumoto, T, Kinoshita, T. | Deposit date: | 2014-10-07 | Release date: | 2015-01-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner. Bioorg.Med.Chem.Lett., 25, 2015
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3VUI
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![BU of 3vui by Molmil](/molmil-images/mine/3vui) | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | Descriptor: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-06-28 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUG
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![BU of 3vug by Molmil](/molmil-images/mine/3vug) | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | Descriptor: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-06-28 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUH
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![BU of 3vuh by Molmil](/molmil-images/mine/3vuh) | Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1 | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ... | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-06-28 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUD
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![BU of 3vud by Molmil](/molmil-images/mine/3vud) | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | Descriptor: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-06-28 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUM
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![BU of 3vum by Molmil](/molmil-images/mine/3vum) | Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, ... | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-07-02 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUL
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![BU of 3vul by Molmil](/molmil-images/mine/3vul) | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | Descriptor: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1 | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-07-02 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3VUK
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![BU of 3vuk by Molmil](/molmil-images/mine/3vuk) | Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1 | Descriptor: | Mitogen-activated protein kinase 8, Peptide from C-Jun-amino-terminal kinase-interacting protein 1, SULFATE ION | Authors: | Nakaniwa, T, Kinoshita, T, Inoue, T. | Deposit date: | 2012-07-02 | Release date: | 2013-02-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1 Biochemistry, 51, 2012
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3A4O
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![BU of 3a4o by Molmil](/molmil-images/mine/3a4o) | Lyn kinase domain | Descriptor: | STAUROSPORINE, Tyrosine-protein kinase Lyn | Authors: | Miyano, N, Kinoshita, T, Tada, T. | Deposit date: | 2009-07-11 | Release date: | 2009-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the inhibitor recognition of human Lyn kinase domain Bioorg.Med.Chem.Lett., 19, 2009
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