4CTH
| Neprilysin variant G399V,G714K in complex with phosphoramidon | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ... | Authors: | Webster, C.I, Burrell, M, Olsson, L, Fowler, S.B, Digby, S, Sandercock, A, Snijder, A, Tebbe, J, Haupts, U, Grudzinska, J, Jermutus, L, Andersson, C. | Deposit date: | 2014-03-13 | Release date: | 2014-08-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease. Plos One, 9, 2014
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6YV5
| Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus | Descriptor: | SODIUM ION, Serine protease | Authors: | Rangel Pereira, M.R, Brear, P, Knyphausen, P, Jermutus, L, Hollfelder, F. | Deposit date: | 2020-04-27 | Release date: | 2021-05-12 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus To Be Published
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6YV6
| Crystal Structure of Serine protease SplB N2K/N3Q/S154R from Staphylococcus aureus | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, Serine protease | Authors: | Rangel Pereira, M.R, Brear, P, Knyphausen, P, Jermutus, L, Hollfelder, F. | Deposit date: | 2020-04-27 | Release date: | 2021-05-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Crystal Structure of Serine protease SplB N2K/N3Q/S154R from Staphylococcus aureus to be published
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4HJ0
| Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution | Descriptor: | Gastric inhibitory polypeptide receptor, Gipg013 Fab, Antagonizing antibody to the GIP Receptor, ... | Authors: | Madhurantakam, C, Ravn, P, Gruetter, M.G, Jackson, R.H. | Deposit date: | 2012-10-12 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor. J.Biol.Chem., 288, 2013
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6BFT
| Structure of Bevacizumab Fab mutant in complex with VEGF | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Avastin Heavy Chain Fab fragment mutant, Avastin Light Chain Fab fragment mutant, ... | Authors: | Christie, M, Christ, D. | Deposit date: | 2017-10-27 | Release date: | 2018-10-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Stable human IgG antibody therapeutics with native
framework structure To Be Published
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6BGT
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3TJE
| Crystal structure of Fas receptor extracellular domain in complex with Fab E09 | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Zuger, S, Stirnimann, C, Briand, C, Grutter, M.G. | Deposit date: | 2011-08-24 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Differ., 19, 2012
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3THM
| Crystal structure of Fas receptor extracellular domain in complex with Fab EP6b_B01 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fab EP6b_B01, ... | Authors: | Zuger, S, Stirnimann, C, Briand, C, Grutter, M.G. | Deposit date: | 2011-08-19 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Differ., 19, 2012
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3EO0
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3EO1
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1P4I
| Crystal Structure of scFv against peptide GCN4 | Descriptor: | ANTIBODY VARIABLE LIGHT CHAIN, antibody variable heavy chain | Authors: | Zahnd, C, Spinelli, S, Luginbuhl, B, Jermutus, L, Amstutz, P, Cambillau, C, Pluckthun, A. | Deposit date: | 2003-04-23 | Release date: | 2004-05-04 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Directed in Vitro Evolution and Crystallographic Analysis of a Peptide-binding Single Chain Antibody Fragment (scFv) with Low Picomolar Affinity. J.Biol.Chem., 279, 2004
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1P4B
| Three-Dimensional Structure Of a Single Chain Fv Fragment Complexed With The peptide GCN4(7P-14P). | Descriptor: | Antibody Variable heavy chain, Antibody Variable light chain, GCN4(7P-14P) peptide | Authors: | Zahnd, C, Spinelli, S, Luginbuhl, B, Jermutus, L, Amstutz, P, Cambillau, C, Pluckthun, A. | Deposit date: | 2003-04-22 | Release date: | 2004-05-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Directed in Vitro Evolution and Crystallographic Analysis of a Peptide-binding Single Chain Antibody Fragment (scFv) with Low Picomolar Affinity. J.Biol.Chem., 279, 2004
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