3TJE
Crystal structure of Fas receptor extracellular domain in complex with Fab E09
Summary for 3TJE
Entry DOI | 10.2210/pdb3tje/pdb |
Related | 3THM |
Descriptor | Fab E09, light chain, Fab E09, heavy chain, Tumor necrosis factor receptor superfamily member 6, ... (7 entities in total) |
Functional Keywords | agonistic antibody, fab fragment, antibody-receptor complex, tumor necrosis factor receptor, cysteine-rich domain, fas, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted: P25445 |
Total number of polymer chains | 3 |
Total formula weight | 67221.12 |
Authors | Zuger, S.,Stirnimann, C.,Briand, C.,Grutter, M.G. (deposition date: 2011-08-24, release date: 2012-05-09, Last modification date: 2023-09-13) |
Primary citation | Chodorge, M.,Zuger, S.,Stirnimann, C.,Briand, C.,Jermutus, L.,Grutter, M.G.,Minter, R.R. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Differ., 19:1187-1195, 2012 Cited by PubMed: 22261618DOI: 10.1038/cdd.2011.208 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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