8W20
| Umb1 umbrella toxin particle | Descriptor: | Intein C-terminal splicing domain-containing protein, Secreted esterase, Secreted protein | Authors: | Park, Y.J, Zhao, Q, Seattle Structural Genomics Center for Infectious Disease (SSGCID), DiMaio, F, Mougous, J.D, Veesler, D. | Deposit date: | 2024-02-19 | Release date: | 2024-04-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Streptomyces umbrella toxin particles block hyphal growth of competing species. Nature, 629, 2024
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8XKV
| Cryo-EM structure of the Ycf2-FtsHi motor complex from Arabidopsis in Apo state | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ATP-dependent zinc metalloprotease FTSH 12, chloroplastic, ... | Authors: | Liang, K, Zhan, X, Xu, Q, Wu, J, Yan, Z. | Deposit date: | 2023-12-25 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into the chloroplast protein import in land plants. Cell, 2024
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8XQO
| Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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1CB8
| CHONDROITINASE AC LYASE FROM FLAVOBACTERIUM HEPARINUM | Descriptor: | CALCIUM ION, GLYCEROL, PROTEIN (CHONDROITINASE AC), ... | Authors: | Fethiere, J, Eggimann, B, Cygler, M. | Deposit date: | 1999-03-02 | Release date: | 1999-05-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of chondroitin AC lyase, a representative of a family of glycosaminoglycan degrading enzymes. J.Mol.Biol., 288, 1999
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8XQS
| Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XKU
| Cryo-EM structure of the Ycf2-FtsHi motor complex from Arabidopsis in ATP-bound state | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent zinc metalloprotease FTSH 12, ... | Authors: | Liang, K, Zhan, X, Xu, Q, Wu, J, Yan, Z. | Deposit date: | 2023-12-24 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the chloroplast protein import in land plants. Cell, 2024
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8XQP
| Structure of human class T GPCR TAS2R14-Gustducin complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQN
| Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQL
| Structure of human class T GPCR TAS2R14-miniGs/gust complex with Aristolochic acid A. | Descriptor: | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8W5C
| Crystal structure of FGFR4 kinase domain in complex with 8K | Descriptor: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide | Authors: | Zhang, Z.M, Huang, H.S. | Deposit date: | 2023-08-26 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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8YKY
| Structure of human class T GPCR TAS2R14-Ggustducin complex with agonist 28.1 | Descriptor: | 4-methyl-N-[(2M)-2-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine, CHOLESTEROL, G alpha gustducin protein, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-03-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQT
| Structure of human class T GPCR TAS2R14-Gi complex. | Descriptor: | CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hu, X.L, Pei, Y, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8XQR
| Structure 2 of human class T GPCR TAS2R14-miniGs/gust complex with Flufenamic acid. | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | Deposit date: | 2024-01-05 | Release date: | 2024-07-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature, 631, 2024
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8Y74
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6KKS
| Structural insights into target DNA recognition by R2R3-type MYB transcription factor | Descriptor: | DNA (5'-D(*AP*AP*AP*TP*TP*CP*TP*CP*CP*AP*AP*CP*CP*GP*CP*AP*TP*TP*TP*TP*C)-3'), DNA (5'-D(*CP*GP*AP*AP*AP*AP*TP*GP*CP*GP*GP*TP*TP*GP*GP*AP*GP*AP*AP*TP*T)-3'), MAGNESIUM ION, ... | Authors: | Wang, B, Luo, Q. | Deposit date: | 2019-07-27 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural insights into target DNA recognition by R2R3-MYB transcription factors. Nucleic Acids Res., 48, 2020
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8IF5
| AFB1-AF26 APTAMER COMPLEX | Descriptor: | AFB1 DNA aptamer (26-MER), AFLATOXIN B1 | Authors: | Xu, G.H, Wang, C, Li, C.G. | Deposit date: | 2023-02-17 | Release date: | 2023-07-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for high-affinity recognition of aflatoxin B1 by a DNA aptamer. Nucleic Acids Res., 51, 2023
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1AJ5
| CALPAIN DOMAIN VI APO | Descriptor: | CALPAIN | Authors: | Cygler, M, Grochulski, P, Blanchard, H. | Deposit date: | 1997-05-15 | Release date: | 1998-05-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat.Struct.Biol., 4, 1997
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7CGN
| The overall structure of the MlaFEDB complex in ATP-bound EQtall conformation (Mutation of E170Q on MlaF) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | Authors: | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-07-01 | Release date: | 2020-09-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
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7CGE
| The overall structure of nucleotide free MlaFEDB complex | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | Authors: | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-07-01 | Release date: | 2020-09-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
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5YF1
| Crystal structure of CARNMT1 bound to carnosine and SFG | Descriptor: | (2~{S})-2-(3-azanylpropanoylamino)-3-(1~{H}-imidazol-4-yl)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Cao, R, Li, H. | Deposit date: | 2017-09-20 | Release date: | 2018-08-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res., 28, 2018
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9AQZ
| Crystal structure of Bcl-xL in complex with a small molecule inhibitor | Descriptor: | (3M)-3-(1-{[(1r,3R,5S,7r)-adamantan-1-yl]methyl}-5-methyl-1H-pyrazol-4-yl)-6-{8-[(1,3-benzothiazol-2-yl)carbamoyl]-3,4-dihydroisoquinolin-2(1H)-yl}pyridine-2-carboxylic acid, Bcl-2-like protein 1, CADMIUM ION | Authors: | Judge, R.A, Judd, A.S. | Deposit date: | 2024-02-22 | Release date: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.961 Å) | Cite: | BCL-X L -targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors. Sci Adv, 10, 2024
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7CH0
| The overall structure of the MlaFEDB complex in ATP-bound EQclose conformation (Mutation of E170Q on MlaF) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | Authors: | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | Deposit date: | 2020-07-03 | Release date: | 2020-09-09 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
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5YF0
| Crystal structure of CARNMT1 bound to SAM | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Cao, R, Zhang, X, Li, H. | Deposit date: | 2017-09-20 | Release date: | 2018-08-01 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res., 28, 2018
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1CJL
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1DIB
| HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899 | Descriptor: | 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | Deposit date: | 1999-11-29 | Release date: | 2000-07-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry, 39, 2000
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