6PQA
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6PSC
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![BU of 6psc by Molmil](/molmil-images/mine/6psc) | Antibody scFv-M204 trimeric state | Descriptor: | scFv-M204 antibody | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | Deposit date: | 2019-07-12 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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2Z9H
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![BU of 2z9h by Molmil](/molmil-images/mine/2z9h) | Ethanolamine utilization protein, EutN | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CHLORIDE ION, Ethanolamine utilization protein eutN | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2007-09-20 | Release date: | 2007-10-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | The crystal structure of ethanolamine utilization protein EutN from E. coli To be Published
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2Y3L
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![BU of 2y3l by Molmil](/molmil-images/mine/2y3l) | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3K
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![BU of 2y3k by Molmil](/molmil-images/mine/2y3k) | Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3J
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![BU of 2y3j by Molmil](/molmil-images/mine/2y3j) | Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y5Y
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![BU of 2y5y by Molmil](/molmil-images/mine/2y5y) | Crystal structure of LacY in complex with an affinity inactivator | Descriptor: | 2-sulfanylethyl beta-D-galactopyranoside, BARIUM ION, LACTOSE PERMEASE | Authors: | Chaptal, V, Kwon, S, Sawaya, M.R, Guan, L, Kaback, H.R, Abramson, J. | Deposit date: | 2011-01-19 | Release date: | 2011-06-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y29
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![BU of 2y29 by Molmil](/molmil-images/mine/2y29) | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y2A
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![BU of 2y2a by Molmil](/molmil-images/mine/2y2a) | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | Descriptor: | ACETATE ION, AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2A1B
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![BU of 2a1b by Molmil](/molmil-images/mine/2a1b) | Carboxysome shell protein ccmK2 | Descriptor: | Carbon dioxide concentrating mechanism protein ccmK homolog 2 | Authors: | Kerfeld, C.A, Sawaya, M.R, Tanaka, S, Nguyen, C.V, Phillips, M, Beeby, M, Yeates, T.O. | Deposit date: | 2005-06-20 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Protein structures forming the shell of primitive bacterial organelles Science, 309, 2005
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3CGI
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8FHJ
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![BU of 8fhj by Molmil](/molmil-images/mine/8fhj) | Crystal structure of a FAD monooxygenease from Methylocystis sp. Strain SB2 | Descriptor: | BROMIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Stewart, A.M, Sawaya, M.R, Stewart, C.E. | Deposit date: | 2022-12-14 | Release date: | 2023-05-03 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from Methylocystis strain SB2. Acta Crystallogr.,Sect.F, 79, 2023
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3CIM
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![BU of 3cim by Molmil](/molmil-images/mine/3cim) | Carboxysome shell protein, CcmK2 C-terminal deletion mutant | Descriptor: | Carbon dioxide-concentrating mechanism protein ccmK homolog 2, GLYCEROL, SULFATE ION | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2008-03-11 | Release date: | 2009-02-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci., 18, 2009
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8G2V
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![BU of 8g2v by Molmil](/molmil-images/mine/8g2v) | Cryo-EM structure of recombinant human LECT2 amyloid fibril core | Descriptor: | Leukocyte cell-derived chemotaxin-2 | Authors: | Richards, L.S, Flores, M.D, Zink, S, Schibrowsky, N.A, Sawaya, M.R, Rodriguez, J.A. | Deposit date: | 2023-02-06 | Release date: | 2023-08-16 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.715 Å) | Cite: | Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core. Structure, 31, 2023
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8FQ7
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![BU of 8fq7 by Molmil](/molmil-images/mine/8fq7) | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | Descriptor: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | Authors: | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | Deposit date: | 2023-01-05 | Release date: | 2023-10-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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3DN9
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3DG1
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![BU of 3dg1 by Molmil](/molmil-images/mine/3dg1) | Segment SSTNVG derived from IAPP | Descriptor: | SSTNVG from Islet Amyloid Polypeptide | Authors: | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2008-06-12 | Release date: | 2008-07-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci., 17, 2008
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3DGJ
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![BU of 3dgj by Molmil](/molmil-images/mine/3dgj) | NNFGAIL segment from Islet Amyloid Polypeptide (IAPP or amylin) | Descriptor: | NNFGAIL peptide | Authors: | Wiltzius, J.J, Sievers, S.A, Sawaya, M.R, Cascio, D, Eisenberg, D. | Deposit date: | 2008-06-13 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci., 17, 2008
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8G47
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![BU of 8g47 by Molmil](/molmil-images/mine/8g47) | KRAS G12C complex with GDP and AMG 510 imaged on a cryo-EM imaging scaffold | Descriptor: | AMG 510 (bound form), GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-02-08 | Release date: | 2023-08-09 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G3K
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8G4H
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![BU of 8g4h by Molmil](/molmil-images/mine/8g4h) | KRAS G13C complex with GDP imaged on a cryo-EM imaging scaffold | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-02-09 | Release date: | 2023-08-09 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G4E
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8G42
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![BU of 8g42 by Molmil](/molmil-images/mine/8g42) | KRAS G12C complex with GDP imaged on a cryo-EM imaging scaffold | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-02-08 | Release date: | 2023-08-09 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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8G4F
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![BU of 8g4f by Molmil](/molmil-images/mine/8g4f) | KRAS G12V complex with GDP imaged on a cryo-EM imaging scaffold | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Castells-Graells, R, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2023-02-09 | Release date: | 2023-08-09 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Cryo-EM structure determination of small therapeutic protein targets at 3 angstrom -resolution using a rigid imaging scaffold. Proc.Natl.Acad.Sci.USA, 120, 2023
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3DNC
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![BU of 3dnc by Molmil](/molmil-images/mine/3dnc) | Carboxysome shell protein, CcmK2 C-terminal deletion mutant, with a closer spacing between hexamers | Descriptor: | Carbon dioxide-concentrating mechanism protein ccmK homolog 2, GLYCEROL, SULFATE ION | Authors: | Tanaka, S, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2008-07-01 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Insights from multiple structures of the shell proteins from the beta-carboxysome. Protein Sci., 18, 2009
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