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4JEF
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BU of 4jef by Molmil
Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Descriptor: SULFATE ION, Thymidylate synthase
Authors:Tochowicz, A, Stroud, R.M, Wade, R.C.
Deposit date:2013-02-26
Release date:2014-08-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.311 Å)
Cite:Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
J.Med.Chem., 58, 2015
4LGT
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BU of 4lgt by Molmil
Crystal structure of the catalytic domain of RluB in complex with a 21-nucleotide RNA substrate
Descriptor: Ribosomal large subunit pseudouridine synthase B, stem-loop of 23S rRNA
Authors:Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M.
Deposit date:2013-06-28
Release date:2013-11-20
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014
1NG1
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BU of 1ng1 by Molmil
N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CADMIUM ION, ...
Authors:Freymann, D.M, Stroud, R.M, Walter, P.
Deposit date:1998-04-30
Release date:1999-07-30
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nat.Struct.Biol., 6, 1999
4LAB
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BU of 4lab by Molmil
Crystal structure of the catalytic domain of RluB
Descriptor: CHLORIDE ION, PLATINUM (II) ION, Ribosomal large subunit pseudouridine synthase B
Authors:Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M.
Deposit date:2013-06-19
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5043 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014
1NN6
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BU of 1nn6 by Molmil
Human Pro-Chymase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase
Authors:Reiling, K.K, Krucinski, J, Miercke, L.J.W, Raymond, W.W, Caughey, G.H, Stroud, R.M.
Deposit date:2003-01-12
Release date:2003-03-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
Biochemistry, 42, 2003
4M8B
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BU of 4m8b by Molmil
Fungal Protein
Descriptor: 1,2-ETHANEDIOL, Chain A of dsDNA containing the cis-regulatory element, Chain B of dsDNA containing the cis-regulatory element, ...
Authors:Rosenberg, O.S, Lohse, M.L, Stroud, R.M, Johnson, A.D.
Deposit date:2013-08-13
Release date:2014-06-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.
Proc.Natl.Acad.Sci.USA, 111, 2014
4LYA
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BU of 4lya by Molmil
EssC (ATPases 2 and 3) from Geobacillus thermodenitrificans (SeMet)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein
Authors:Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S.
Deposit date:2013-07-30
Release date:2015-02-04
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.
Cell(Cambridge,Mass.), 161, 2015
4LXJ
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BU of 4lxj by Molmil
Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound
Descriptor: LANOSTEROL, Lanosterol 14-alpha demethylase, OXYGEN MOLECULE, ...
Authors:Monk, B.C, Tomasiak, T.M, Keniya, M.V, Huschmann, F.U, Tyndall, J.D.A, O'Connell III, J.D, Cannon, R.D, McDonald, J, Rodriguez, A, Finer-Moore, J, Stroud, R.M.
Deposit date:2013-07-29
Release date:2014-01-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Proc.Natl.Acad.Sci.USA, 111, 2014
3AID
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BU of 3aid by Molmil
A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
Descriptor: BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM, HUMAN IMMUNODEFICIENCY VIRUS PROTEASE
Authors:Rutenber, E.E, Stroud, R.M.
Deposit date:1997-05-15
Release date:1997-09-17
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorg.Med.Chem., 4, 1996
3C02
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BU of 3c02 by Molmil
X-ray structure of the aquaglyceroporin from Plasmodium falciparum
Descriptor: Aquaglyceroporin, GLYCEROL, octyl beta-D-glucopyranoside
Authors:Newby, Z.E, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2008-01-18
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Nat.Struct.Mol.Biol., 15, 2008
3C4T
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BU of 3c4t by Molmil
Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer
Descriptor: CADMIUM ION, Endoribonuclease Dicer
Authors:Lee, J.K, Du, Z, Tjhen, R.J, Stroud, R.M, James, T.L.
Deposit date:2008-01-30
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BHS
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BU of 3bhs by Molmil
Nitrosomonas europaea Rh50 and mechanism of conduction by Rhesus protein family of channels
Descriptor: Ammonium transporter family protein Rh50
Authors:Gruswitz, F, Ho, C.-M, del Rosario, M.C, Westhoff, C.M, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2007-11-29
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Nitrosomonas europaea Rh50 and mechanism of conduction by Rhesus protein family of channels.
To be Published
3DH3
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BU of 3dh3 by Molmil
Crystal Structure of RluF in complex with a 22 nucleotide RNA substrate
Descriptor: Ribosomal large subunit pseudouridine synthase F, stem loop fragment of E. Coli 23S RNA
Authors:Alian, A, DeGiovanni, A, Stroud, R.M, Finer-Moore, J.S.
Deposit date:2008-06-16
Release date:2009-04-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
J.Mol.Biol., 388, 2009
3BT7
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BU of 3bt7 by Molmil
Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue
Descriptor: RNA (5'-D(P*GP*CP*UP*GP*UP*GP*(5MU)P*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*GP*C)-3'), tRNA (uracil-5-)-methyltransferase
Authors:Alian, A, Stroud, R.M, Finer-Moore, J.
Deposit date:2007-12-27
Release date:2008-04-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1VZE
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BU of 1vze by Molmil
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH DUMP AND CB3717
Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein Eng., 11, 1998
1VZD
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BU of 1vzd by Molmil
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH FDUMP AND CB3717
Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein Eng., 11, 1998
1VZA
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BU of 1vza by Molmil
THYMIDYLATE SYNTHASE E60D MUTANT BINARY COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein Eng., 11, 1998
1VZC
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BU of 1vzc by Molmil
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q BINARY COMPLEX WITH FDUMP
Descriptor: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein Eng., 11, 1998
3DM5
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BU of 3dm5 by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-30
Release date:2008-11-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
3DZE
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BU of 3dze by Molmil
Crystal structure of bovine coupling Factor B bound with cadmium
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP synthase subunit s, mitochondrial, ...
Authors:Lee, J.K, Stroud, R.M, Belogrudov, G.I.
Deposit date:2008-07-29
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal structure of bovine mitochondrial factor B at 0.96-A resolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DLV
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BU of 3dlv by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: Signal recognition particle 19 kDa protein
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-29
Release date:2008-11-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
3DMD
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BU of 3dmd by Molmil
Structures and Conformations in Solution of the Signal Recognition Particle Receptor from the archaeon Pyrococcus furiosus
Descriptor: GLYCEROL, SULFATE ION, Signal recognition particle receptor
Authors:Egea, P.F, Tsuruta, H, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-30
Release date:2008-11-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane.
Plos One, 3, 2008
1VZB
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BU of 1vzb by Molmil
L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q BINARY COMPLEX WITH DUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
Authors:Birdsall, D.L, Finer-Moore, J, Stroud, R.M.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Protein Eng., 11, 1998
3DLU
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BU of 3dlu by Molmil
Structures of SRP54 and SRP19, the two proteins assembling the ribonucleic core of the Signal Recognition Particle from the archaeon Pyrococcus furiosus.
Descriptor: BROMIDE ION, MALONATE ION, Signal recognition particle 19 kDa protein
Authors:Egea, P.F, Napetschnig, J, Walter, P, Stroud, R.M.
Deposit date:2008-06-29
Release date:2008-11-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus.
Plos One, 3, 2008
1UWV
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BU of 1uwv by Molmil
Crystal Structure of RumA, the iron-sulfur cluster containing E. coli 23S Ribosomal RNA 5-Methyluridine Methyltransferase
Descriptor: 23S RRNA (URACIL-5-)-METHYLTRANSFERASE RUMA, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
Authors:Lee, T.T, Agarwalla, S, Stroud, R.M.
Deposit date:2004-02-11
Release date:2004-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Ruma, an Iron-Sulfur Cluster Containing E. Coli Ribosomal RNA 5-Methyluridine Methyltransferase.
Structure, 12, 2004

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