3AID
A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
Summary for 3AID
Entry DOI | 10.2210/pdb3aid/pdb |
Descriptor | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM (3 entities in total) |
Functional Keywords | aspartyl protease, protease, hiv, peptide isostere inhibitor, drug design |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22108.17 |
Authors | Rutenber, E.E.,Stroud, R.M. (deposition date: 1997-05-15, release date: 1997-09-17, Last modification date: 2023-08-09) |
Primary citation | Rutenber, E.E.,McPhee, F.,Kaplan, A.P.,Gallion, S.L.,Hogan Jr., J.C.,Craik, C.S.,Stroud, R.M. A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere. Bioorg.Med.Chem., 4:1545-1558, 1996 Cited by PubMed: 8894111DOI: 10.1016/0968-0896(96)00147-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report