3AID
A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE | polymer | 99 | 10801.8 | 2 | UniProt (P03369) Pfam (PF00077) | Human immunodeficiency virus 1 | HIV PROTEASE, HIV PR |
| 2 | C (A) | BENZOYLAMINO-BENZYL-METHYL-[2-HYDROXY-3-[1-METHYL-ETHYL-OXY-N-FORMAMIDYL]-4-PHENYL-BUTYL]-AMMONIUM | non-polymer | 504.6 | 1 | Chemie (ARQ) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21603.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 22108.2 |
