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4Q4N
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BU of 4q4n by Molmil
Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at H432
Descriptor: Peptidoglycan endopeptidase RipA
Authors:Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R.
Deposit date:2014-04-15
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine.
Acta Crystallogr.,Sect.D, 70, 2014
4Q4T
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BU of 4q4t by Molmil
Structure of the Resuscitation Promoting Factor Interacting protein RipA mutated at E444
Descriptor: FORMIC ACID, GLYCEROL, Peptidoglycan endopeptidase RipA
Authors:Squeglia, F, Ruggiero, A, Romano, M, Vitagliano, L, Berisio, R.
Deposit date:2014-04-15
Release date:2014-09-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Mutational and structural study of RipA, a key enzyme in Mycobacterium tuberculosis cell division: evidence for the L-to-D inversion of configuration of the catalytic cysteine.
Acta Crystallogr.,Sect.D, 70, 2014
2IU7
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BU of 2iu7 by Molmil
Site directed mutagenesis of key residues involved in the catalytic mechanism of Cyanase
Descriptor: CYANATE HYDRATASE, OXALATE ION, SULFATE ION
Authors:Guilloton, M, Walsh, M.A, Joachimiak, A, Anderson, P.M.
Deposit date:2006-05-30
Release date:2006-06-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:A Twin Set of Low Pka Arginines Ensures the Concerted Acid Base Catalytic Mechanism of Cyanase
To be Published
5I2V
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BU of 5i2v by Molmil
NMR structure of a new G-quadruplex forming sequence within the KRAS proto-oncogene promoter region
Descriptor: DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*TP*GP*TP*GP*GP*GP*AP*AP*TP*AP*GP*GP*GP*AP*A)-3'), POTASSIUM ION
Authors:Salgado, G.F, Kerkour, A, Mergny, J.-L.
Deposit date:2016-02-09
Release date:2016-03-16
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.
J. Biol. Chem., 292, 2017
4QAF
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BU of 4qaf by Molmil
Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Descriptor: 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ACETATE ION, Lipocalin-1, ...
Authors:Giese, T, Skerra, A.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold
To be Published
3IHG
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BU of 3ihg by Molmil
Crystal structure of a ternary complex of aklavinone-11 hydroxylase with FAD and aklavinone
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, RdmE, SULFATE ION, ...
Authors:Lindqvist, Y, Koskiniemi, H, Jansson, A, Sandalova, T, Schneider, G.
Deposit date:2009-07-30
Release date:2009-09-29
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
J.Mol.Biol., 393, 2009
2IU6
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BU of 2iu6 by Molmil
REGULATION OF THE DHA OPERON OF LACTOCOCCUS LACTIS
Descriptor: DIHYDROXYACETONE KINASE, GLYCEROL
Authors:Srinivas, A, Christen, S, Baumann, U, Erni, B.
Deposit date:2006-05-27
Release date:2006-06-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Regulation of the Dha Operon of Lactococcus Lactis: A Deviation from the Rule Followed by the Tetr Family of Transcription Regulators
J.Biol.Chem., 281, 2006
5IUJ
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BU of 5iuj by Molmil
Crystal structure of the DesK-DesR complex in the phosphotransfer state with low Mg2+ (20 mM)
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ...
Authors:Trajtenberg, F, Imelio, J.A, Larrieux, N, Buschiazzo, A.
Deposit date:2016-03-18
Release date:2016-12-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.
Elife, 5, 2016
2IZ7
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BU of 2iz7 by Molmil
structure of Moco Carrier Protein from Chlamydomonas reinhardtii
Descriptor: MOCO CARRIER PROTEIN
Authors:Fischer, K, Llamas, A, Tejada-Jimenez, M, Schrader, N, Kuper, J, Mendel, R.R, Fernandez, E, Schwarz, G.
Deposit date:2006-07-25
Release date:2006-07-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Function and Structure of the Molybdenum Cofactor Carrier Protein from Chlamydomonas Reinhardtii.
J.Biol.Chem., 281, 2006
4QBX
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BU of 4qbx by Molmil
Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A
Descriptor: Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Rechlin, C, Heine, A, Klebe, G.
Deposit date:2014-05-09
Release date:2015-07-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation
To be Published
3IYV
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BU of 3iyv by Molmil
Clathrin D6 coat as full-length Triskelions
Descriptor: Clathrin heavy chain, Clathrin light chain A
Authors:Johnson, G.T, Fotin, A, Cheng, Y, Sliz, P, Grigorieff, N, Harrison, S.C, Kirchhausen, T, Walz, T.
Deposit date:2010-06-17
Release date:2010-07-21
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Molecular model for a complete clathrin lattice from electron cryomicroscopy.
Nature, 432, 2004
2IVG
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BU of 2ivg by Molmil
SITE DIRECTED MUTAGENESIS OF KEY RESIDUES INVOLVED IN THE CATALYTIC MECHANISM OF CYANASE
Descriptor: AZIDE ION, CHLORIDE ION, CYANATE LYASE, ...
Authors:Guilloton, M, Walsh, M.A, Joachimiak, A, Anderson, P.M.
Deposit date:2006-06-13
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:A Twin Set of Low Pka Arginines Ensures the Concerted Acid Base Catalytic Mechanism of Cyanase
To be Published
2IZ6
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BU of 2iz6 by Molmil
Structure of the Chlamydomonas rheinhardtii Moco Carrier Protein
Descriptor: MOLYBDENUM COFACTOR CARRIER PROTEIN
Authors:Fischer, K, Llamas, A, Tejada-Jimenez, M, Schrader, N, Kuper, J, Mendel, R.R, Fernandez, E, Schwarz, G.
Deposit date:2006-07-25
Release date:2006-07-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Function and Structure of the Molybdenum Cofactor Carrier Protein from Chlamydomonas Reinhardtii.
J.Biol.Chem., 281, 2006
5IUL
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BU of 5iul by Molmil
Crystal structure of the DesK-DesR complex in the phosphotransfer state with high Mg2+ (150 mM) and BeF3
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, POTASSIUM ION, ...
Authors:Trajtenberg, F, Imelio, J.A, Larrieux, N, Buschiazzo, A.
Deposit date:2016-03-18
Release date:2016-12-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.153 Å)
Cite:Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.
Elife, 5, 2016
5IWO
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BU of 5iwo by Molmil
Bacterial sodium channel pore domain, low bromide
Descriptor: BROMIDE ION, Ion transport protein
Authors:Shaya, D, Findeisen, F, Rohaim, A, Minor, D.L.
Deposit date:2016-03-22
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
Cell, 164, 2016
3W35
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BU of 3w35 by Molmil
Crystal structure of apo-type bacterial Vanadium-dependent chloroperoxidase
Descriptor: NapH1
Authors:Liscombe, D.K, Miyanaga, A, Fielding, E, Bernhardt, P, Li, A, Winter, J.M, Gilson, M.K, Noel, J.P, Moore, B.S.
Deposit date:2012-12-11
Release date:2013-12-11
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis.
Biochemistry, 2022
5IX8
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BU of 5ix8 by Molmil
Crystal structure of sugar ABC transport system, substrate-binding protein from Bordetella parapertussis 12822
Descriptor: 1,2-ETHANEDIOL, Putative sugar ABC transport system, substrate-binding protein, ...
Authors:Chang, C, Cuff, M, Joachimiak, G, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2016-03-23
Release date:2016-04-06
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of sugar ABC transport system, substrate-binding protein from Bordetella parapertussis 12822
To Be Published
7N4T
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BU of 7n4t by Molmil
Low conductance mechanosensitive channel YnaI
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Low conductance mechanosensitive channel YnaI
Authors:Catalano, C, Ben-Hail, D, Qiu, W, des Georges, A, Guo, Y.
Deposit date:2021-06-04
Release date:2022-04-20
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of Mechanosensitive Channel YnaI Using SMA2000: Challenges and Opportunities.
Membranes (Basel), 11, 2021
2IVB
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BU of 2ivb by Molmil
SITE DIRECTED MUTAGENESIS OF KEY RESIDUES INVOLVED IN THE CATALYTIC MECHANISM OF CYANASE
Descriptor: AZIDE ION, CHLORIDE ION, CYANATE HYDRATASE, ...
Authors:Guilloton, M, Walsh, M.A, Joachimiak, A, Anderson, P.M.
Deposit date:2006-06-09
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A Twin Set of Low Pka Arginines Ensures the Concerted Acid Base Catalytic Mechanism of Cyanase
To be Published
5IXP
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BU of 5ixp by Molmil
Crystal structure of Extracellular solute-binding protein family 1
Descriptor: Extracellular solute-binding protein family 1, FORMIC ACID
Authors:Chang, C, Cuff, M, Chhor, G, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2016-03-23
Release date:2016-03-30
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of Extracellular solute-binding protein family 1
To Be Published
4PYM
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BU of 4pym by Molmil
humanized rat apo-COMT bound to sulphate
Descriptor: Catechol O-methyltransferase, POTASSIUM ION, SULFATE ION
Authors:Ehler, A, Benz, J, Schlatter, D, Rudolph, M.G.
Deposit date:2014-03-27
Release date:2014-06-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Mapping the conformational space accessible to catechol-O-methyltransferase.
Acta Crystallogr.,Sect.D, 70, 2014
2IZ5
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BU of 2iz5 by Molmil
FUNCTION AND STRUCTURE OF THE MOLYBDENUM COFACTOR CARRIER PROTEIN MCP FROM CHLAMYDOMONAS REINHARDTII
Descriptor: MOCO CARRIER PROTEIN
Authors:Fischer, K, Llamas, A, Tejada-Jimenez, M, Schrader, N, Kuper, J, Mendel, R.R, Fernandez, E, Schwarz, G.
Deposit date:2006-07-25
Release date:2006-07-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Function and Structure of the Molybdenum Cofactor Carrier Protein from Chlamydomonas Reinhardtii.
J.Biol.Chem., 281, 2006
4Q1B
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BU of 4q1b by Molmil
Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 7 {N-(2-(3-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)phenoxy)ethyl)methanesulfonamide}
Descriptor: Deoxycytidine kinase, N-(2-(3-(4-(((4,6-diaminopyrimidin-2-yl)thio)methyl)-5-propylthiazol-2-yl)phenoxy)ethyl)methanesulfonamide, URIDINE-5'-DIPHOSPHATE
Authors:Nomme, J, Lavie, A.
Deposit date:2014-04-03
Release date:2015-02-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J.Med.Chem., 57, 2014
3STK
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BU of 3stk by Molmil
Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)
Descriptor: Fatty acid-binding protein, liver, PALMITIC ACID
Authors:Sharma, A, Sharma, A.
Deposit date:2011-07-11
Release date:2011-08-10
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Fatty acid induced remodeling within the Human liver fatty acid binding protein
J.Biol.Chem., 2011
4Q23
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BU of 4q23 by Molmil
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Descriptor: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ...
Authors:Tsoumpra, M.K, Muniz, J.R.C, Barnett, B.L, Kwaasi, A.A, Pilka, E.S, Kavanagh, K.L, Evdokimov, A, Walter, R.L, Ebetino, F.H, von Delft, F, Oppermann, U, Russell, R.G.G, Dunford, J.E.
Deposit date:2014-04-05
Release date:2015-03-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
To be Published

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数据于2024-07-17公开中

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