6WTQ
 
 | | Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4 | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide, ... | | Authors: | Yu, S, Nithianantham, S, Fischer, M. | | Deposit date: | 2020-05-03 | | Release date: | 2021-05-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.79968476 Å) | | Cite: | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood, 138, 2021
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6WTN
 | | Human JAK2 JH1 domain in complex with Ruxolitinib | | Descriptor: | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, 1,2-ETHANEDIOL, Tyrosine-protein kinase JAK2 | | Authors: | Yu, S, Nithianantham, S, Fischer, M. | | Deposit date: | 2020-05-03 | | Release date: | 2021-05-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood, 138, 2021
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6WTP
 | | Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 3 | | Descriptor: | GLYCEROL, Tyrosine-protein kinase JAK2, tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | | Authors: | Yu, S, Nithianantham, S, Fischer, M. | | Deposit date: | 2020-05-03 | | Release date: | 2021-05-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood, 138, 2021
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6WTO
 | | Human JAK2 JH1 domain in complex with Baricitinib | | Descriptor: | 1,2-ETHANEDIOL, Baricitinib, Tyrosine-protein kinase JAK2 | | Authors: | Yu, S, Nithianantham, S, Fischer, M. | | Deposit date: | 2020-05-03 | | Release date: | 2021-05-05 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood, 138, 2021
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6XIZ
 | | Crystal structure of multi-copper oxidase from Pediococcus acidilactici | | Descriptor: | BENZAMIDINE, CHLORIDE ION, COPPER (II) ION, ... | | Authors: | Pardo, I, Soares, A.S, Collins, R, Partowmah, S.H, Coler, E.A. | | Deposit date: | 2020-06-22 | | Release date: | 2021-03-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species.
Microb Biotechnol, 14, 2021
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6XJ0
 | | Crystal structure of multi-copper oxidase from Pediococcus pentosaceus | | Descriptor: | CHLORIDE ION, COPPER (II) ION, CU-O-CU LINKAGE, ... | | Authors: | Pardo, I, Soares, A.S, Collins, R, Partowmah, S.H, Coler, E.A. | | Deposit date: | 2020-06-22 | | Release date: | 2021-03-10 | | Last modified: | 2021-05-12 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species.
Microb Biotechnol, 14, 2021
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8C8P
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8BK9
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8BKB
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8BL7
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8BLD
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8BLY
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8BMO
 | | Structure of GroEL:GroES complex exhibiting ADP-conformation in trans ring obtained under the continuous turnover conditions | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, Co-chaperonin GroES, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-10 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BLE
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8BL2
 | | Structure of GroEL-ATP complex plunge frozen 200 ms after reaction initiation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, MAGNESIUM ION, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-09 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BKA
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8BKZ
 | | GroEL:GroES-ATP complex under continuous turnover conditions | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, Co-chaperonin GroES, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-09 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BM1
 | | Structure of GroEL:GroES-ATP complex under continuous turnover conditions | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, Co-chaperonin GroES, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-10 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BK7
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8BMD
 | | Structure of GroEL-ATP complex under continuous turnover conditions | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, MAGNESIUM ION, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-10 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BKG
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8BK8
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8BLF
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8BLC
 | | Structure of the GroEL-ATP complex plunge-frozen 50 ms after mixing with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, MAGNESIUM ION, ... | | Authors: | Dhurandhar, M, Torino, S, Efremov, R. | | Deposit date: | 2022-11-09 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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8BMT
 | | Structure of GroEL:GroES-ATP complex plunge frozen 200 ms after reaction initiation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin GroEL, Co-chaperonin GroES, ... | | Authors: | Dhurandhar, M, Efremov, R, Torino, S. | | Deposit date: | 2022-11-10 | | Release date: | 2023-08-09 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting.
Nat.Methods, 20, 2023
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