4RCA
 
 | | Crystal structure of human PTPdelta and human Slitrk1 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta, SLIT and NTRK-like protein 1, ... | | Authors: | Kim, H.M, Park, B.S, Kim, D, Lee, S.G. | | Deposit date: | 2014-09-15 | | Release date: | 2014-11-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.9908 Å) | | Cite: | Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.
Nat Commun, 5, 2014
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4RCW
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8CLN
 | | Zearalenone lactonase from Streptomyces coelicoflavus, SeMet derivative for SAD phasing | | Descriptor: | Hydrolase | | Authors: | Puehringer, D, Grishkovskaya, I, Mlynek, G, Kostan, J. | | Deposit date: | 2023-02-17 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone.
Acs Catalysis, 14, 2024
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8TAI
 | | TMEM16F, with Calcium and PIP2, no inhibitor, Cl2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | | Authors: | Wu, H, Feng, S, Cheng, Y. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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8TAL
 | | TMEM16F, with Calcium and PIP2, no inhibitor, Cl1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | | Authors: | Wu, H, Feng, S, Cheng, Y. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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8SUR
 | | TMEM16F bound with Niclosamide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... | | Authors: | Feng, S, Cheng, Y. | | Deposit date: | 2023-05-13 | | Release date: | 2023-09-06 | | Last modified: | 2023-11-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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8TAG
 | | TMEM16F, with Calcium and PIP2, no inhibitor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | | Authors: | Feng, S, Cheng, Y. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-06 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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8SUN
 | | TMEM16F 1PBC | | Descriptor: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, ... | | Authors: | Wu, H, Feng, S, Cheng, Y. | | Deposit date: | 2023-05-12 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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3E0F
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3O0F
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7X6C
 | | Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1 | | Descriptor: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | | Authors: | Won, J, Jeong, H, Lee, H.H. | | Deposit date: | 2022-03-07 | | Release date: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
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7X6I
 | | Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1 | | Descriptor: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Won, J, Jeong, H, Lee, H.H. | | Deposit date: | 2022-03-07 | | Release date: | 2023-04-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | Molecular architecture of the G alpha i -bound TRPC5 ion channel.
Nat Commun, 14, 2023
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8CNI
 | | PHT1 in the outward facing conformation, bound to Sb27 | | Descriptor: | Solute carrier family 15 member 4, Sybody 27 | | Authors: | Custodio, T, Killer, M, Loew, C. | | Deposit date: | 2023-02-23 | | Release date: | 2023-09-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.
Nat Commun, 14, 2023
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7TBL
 | | Composite structure of the human nuclear pore complex (NPC) cytoplasmic face generated with a 12A cryo-ET map of the purified HeLa cell NPC | | Descriptor: | DDX19, ELYS, GLE1, ... | | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | | Deposit date: | 2021-12-22 | | Release date: | 2022-06-22 | | Last modified: | 2022-06-29 | | Method: | ELECTRON MICROSCOPY (23 Å) | | Cite: | Architecture of the cytoplasmic face of the nuclear pore.
Science, 376, 2022
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3EYU
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3EYS
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1IZY
 | | Crystal structure of Hsp31 | | Descriptor: | Hsp31 | | Authors: | Cha, S.S, Lee, S.J. | | Deposit date: | 2002-10-16 | | Release date: | 2003-10-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
J.Biol.Chem., 278, 2003
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2R0Z
 | | PFA1 FAB complexed with GripI peptide fragment | | Descriptor: | GLYCEROL, GripI peptide fragment, IgG2a Fab fragment heavy chain, ... | | Authors: | Gardberg, A.S, Dealwis, C. | | Deposit date: | 2007-08-21 | | Release date: | 2007-10-16 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.096 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R0W
 | | PFA2 FAB complexed with Abeta1-8 | | Descriptor: | Amyloid beta peptide fragment, IgG2a Fab fragment heavy chain, Fd portion, ... | | Authors: | Gardberg, A.S, Dealwis, C. | | Deposit date: | 2007-08-21 | | Release date: | 2007-10-16 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.503 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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6USF
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | | Authors: | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | Deposit date: | 2019-10-26 | | Release date: | 2020-04-29 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6UR8
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | | Authors: | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | Deposit date: | 2019-10-22 | | Release date: | 2020-04-29 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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1I2H
 | | CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN | | Descriptor: | PSD-ZIP45(HOMER-1C/VESL-1L) | | Authors: | Irie, K, Nakatsu, T, Mitsuoka, K, Fujiyoshi, Y, Kato, H. | | Deposit date: | 2001-02-09 | | Release date: | 2002-05-29 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of the Homer 1 Family Conserved Region Reveals the Interaction Between the EVH1 Domain and
Own Proline-rich Motif
J.Mol.Biol., 318, 2002
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1IZZ
 | | Crystal structure of Hsp31 | | Descriptor: | Hsp31 | | Authors: | Cha, S.S, Lee, S.J. | | Deposit date: | 2002-10-16 | | Release date: | 2003-10-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain
J.Biol.Chem., 278, 2003
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6MR9
 | | E. coli DHFR complex with a reaction intermediate | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, Dihydrofolate reductase, ... | | Authors: | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | Deposit date: | 2018-10-12 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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6MT8
 | | E. coli DHFR complex modeled with two ligand states | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, DIHYDROFOLIC ACID, ... | | Authors: | Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. | | Deposit date: | 2018-10-19 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate.
Struct Dyn., 6, 2019
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