3ROC
| Crystal structure of human p38 alpha complexed with a pyrimidinone compound | Descriptor: | 3-{5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl}-N-(2-hydroxyethyl)-4-methylbenzamide, 4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 | Authors: | Shieh, H.-S, Xing, L. | Deposit date: | 2011-04-25 | Release date: | 2011-06-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Substituted N-aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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3WDZ
| Crystal Structure of Keap1 in Complex with phosphorylated p62 | Descriptor: | Kelch-like ECH-associated protein 1, Peptide from Sequestosome-1 | Authors: | Fukutomi, T, Takagi, K, Mizushima, T, Tanaka, K, Komatsu, M, Yamamoto, M. | Deposit date: | 2013-06-26 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol.Cell, 51, 2013
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7VOZ
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5GSZ
| Crystal Structure of the KIF19A Motor Domain Complexed with Mg-ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF19, MAGNESIUM ION | Authors: | Wang, D, Nitta, R, Hirokawa, N. | Deposit date: | 2016-08-18 | Release date: | 2016-09-28 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A Elife, 5, 2016
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1L3H
| NMR structure of P41icf, a potent inhibitor of human cathepsin L | Descriptor: | MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf) | Authors: | Chiva, C, Barthe, P, Codina, A, Giralt, E. | Deposit date: | 2002-02-27 | Release date: | 2003-03-04 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Synthesis and NMR structure of P41ICF, a potent inhibitor of human cathepsin L J.Am.Chem.Soc., 125, 2003
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1HCY
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1HC1
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1F88
| CRYSTAL STRUCTURE OF BOVINE RHODOPSIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, RETINAL, ... | Authors: | Okada, T, Palczewski, K, Stenkamp, R.E, Miyano, M. | Deposit date: | 2000-06-29 | Release date: | 2000-08-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of rhodopsin: A G protein-coupled receptor. Science, 289, 2000
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7WM4
| Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | Authors: | Sakaniwa, K, Ohto, U, Shimizu, T. | Deposit date: | 2022-01-14 | Release date: | 2023-01-25 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14, 2023
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6G52
| CRYSTAL STRUCTURE OF THE CNMP BINDING DOMAIN OF THE MAGNESIUM TRANSPORTER CNNM4 | Descriptor: | Metal transporter CNNM4 | Authors: | Gimenez, P, Oyenarte, I, Hardy, S, Zubillaga, M, Merino, N, Blanco, F.J, Siliqi, D, Tremblay, M, Muller, D, Martinez-Cruz, L.A. | Deposit date: | 2018-03-28 | Release date: | 2019-04-10 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.691 Å) | Cite: | Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4. Int J Mol Sci, 20, 2019
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1IBG
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2L4I
| The Solution Structure of Magnesium bound CIB1 | Descriptor: | Calcium and integrin-binding protein 1, MAGNESIUM ION | Authors: | Huang, H, Vogel, H.J. | Deposit date: | 2010-10-06 | Release date: | 2011-03-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structures of Ca2+-CIB1 and Mg2+-CIB1 and Their Interactions with the Platelet Integrin {alpha}IIb Cytoplasmic Domain. J.Biol.Chem., 286, 2011
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2L4H
| The Solution Structure of Calcium Bound CIB1 | Descriptor: | CALCIUM ION, Calcium and integrin-binding protein 1 | Authors: | Huang, H, Vogel, H.J. | Deposit date: | 2010-10-06 | Release date: | 2011-03-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution Structures of Ca2+-CIB1 and Mg2+-CIB1 and Their Interactions with the Platelet Integrin {alpha}IIb Cytoplasmic Domain. J.Biol.Chem., 286, 2011
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6AHP
| Structure of the 58-167 fragment of FliL | Descriptor: | Flagellar protein FliL | Authors: | Takekawa, N, Isumi, M, Sakuma, M, Kojima, S, Homma, M, Imada, K. | Deposit date: | 2018-08-20 | Release date: | 2019-03-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function. MBio, 10, 2019
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6AHQ
| Structure of the 40-167 fragment of FliL | Descriptor: | Flagellar protein FliL | Authors: | Takekawa, N, Isumi, M, Sakuma, M, Kojima, S, Homma, M, Imada, K. | Deposit date: | 2018-08-20 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.398 Å) | Cite: | Structure ofVibrioFliL, a New Stomatin-like Protein That Assists the Bacterial Flagellar Motor Function. MBio, 10, 2019
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6BDY
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6BM6
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6BM5
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4X9J
| EGR-1 with Doubly Methylated DNA | Descriptor: | DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), Early growth response protein 1, ... | Authors: | White, M.A, Zandarashvili, L, Iwahara, J. | Deposit date: | 2014-12-11 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.412 Å) | Cite: | Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. Febs Lett., 589, 2015
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4XIC
| ANTPHD WITH 15BP di-thioate modified DNA DUPLEX | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*GP*CP*(C2S)P*AP*TP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), ... | Authors: | White, M.A, Zandarashvili, L, Iwahara, J. | Deposit date: | 2015-01-06 | Release date: | 2015-11-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Entropic Enhancement of Protein-DNA Affinity by Oxygen-to-Sulfur Substitution in DNA Phosphate. Biophys.J., 109, 2015
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7VTQ
| Cryo-EM structure of mouse NLRP3 (full-length) dodecamer | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | Authors: | Ohto, U, Shimizu, T. | Deposit date: | 2021-10-30 | Release date: | 2022-03-09 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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4HL0
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7VTP
| Cryo-EM structure of PYD-deleted human NLRP3 hexamer | Descriptor: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | Authors: | Ohto, U, Shimizu, T. | Deposit date: | 2021-10-30 | Release date: | 2022-03-09 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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4Y59
| Crystal structure of ALiS1-Streptavidin complex | Descriptor: | 2-[3-(trifluoromethyl)phenyl]furo[3,2-c]pyridin-4(5H)-one, Streptavidin | Authors: | Sugiyama, S, Terai, T, Kohno, M, Ishida, H, Nagano, T. | Deposit date: | 2015-02-11 | Release date: | 2015-09-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport J.Am.Chem.Soc., 137, 2015
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5XOG
| RNA Polymerase II elongation complex bound with Spt5 KOW5 and Elf1 | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (30-MER), DNA (39-MER), ... | Authors: | Ehara, H, Shirouzu, M, Sekine, S. | Deposit date: | 2017-05-28 | Release date: | 2017-08-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the complete elongation complex of RNA polymerase II with basal factors Science, 357, 2017
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