6WFT
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5NSP
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![BU of 5nsp by Molmil](/molmil-images/mine/5nsp) | Crystal structure of TNKS2 in complex with OD334 | Descriptor: | 1-[4-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, BICARBONATE ION, GLYCEROL, ... | Authors: | Nkizinkiko, Y, Haikarainen, T, Lehtio, L. | Deposit date: | 2017-04-26 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60, 2017
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6X2K
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5OQ4
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![BU of 5oq4 by Molmil](/molmil-images/mine/5oq4) | PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology | Descriptor: | 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | Authors: | Williams, R.L, Zhang, X. | Deposit date: | 2017-08-10 | Release date: | 2017-09-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
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7ZOZ
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![BU of 7zoz by Molmil](/molmil-images/mine/7zoz) | Crystal structure of Siglec-15 in complex with Fab | Descriptor: | Anti-Siglec 15 Fab HC, Anti-Siglec 15 Fab LC, Sialic acid-binding Ig-like lectin 15 | Authors: | Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J. | Deposit date: | 2022-04-26 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun, 14, 2023
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7ZOR
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![BU of 7zor by Molmil](/molmil-images/mine/7zor) | Crystal structure of anti-Siglec-15 Fab | Descriptor: | Anti-siglec15 FAB HC, Anti-siglec15 FAB LC | Authors: | Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J. | Deposit date: | 2022-04-26 | Release date: | 2023-06-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.933 Å) | Cite: | Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun, 14, 2023
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6BPY
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![BU of 6bpy by Molmil](/molmil-images/mine/6bpy) | Aspergillus fumigatus Thioredoxin Reductase | Descriptor: | ACETATE ION, D-MALATE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Marshall, A.C, Bruning, J.B. | Deposit date: | 2017-11-27 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Structure, Mechanism, and Inhibition ofAspergillus fumigatusThioredoxin Reductase. Antimicrob.Agents Chemother., 63, 2019
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6ANA
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![BU of 6ana by Molmil](/molmil-images/mine/6ana) | LL2 Fab in complex with anti-Kappa VHH domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, LL2 Fab Heavy Chain, LL2 Fab Light Chain, ... | Authors: | Sicard, T, Ereno Orbea, J, Julien, J.-P. | Deposit date: | 2017-08-12 | Release date: | 2018-01-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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4B4P
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![BU of 4b4p by Molmil](/molmil-images/mine/4b4p) | Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF. | Descriptor: | BROMIDE ION, F18 FIMBRIAL ADHESIN AC, SULFATE ION | Authors: | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | Deposit date: | 2012-07-31 | Release date: | 2012-08-15 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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4B4R
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![BU of 4b4r by Molmil](/molmil-images/mine/4b4r) | Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF in complex with blood group B type 1 hexasaccharide | Descriptor: | F18 FIMBRIAL ADHESIN AC, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | Deposit date: | 2012-07-31 | Release date: | 2012-08-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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4B4Q
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![BU of 4b4q by Molmil](/molmil-images/mine/4b4q) | Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF in complex with blood group A type 1 hexasaccharide | Descriptor: | F18 FIMBRIAL ADHESIN AC, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | Deposit date: | 2012-07-31 | Release date: | 2012-08-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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6CZS
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4GEV
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![BU of 4gev by Molmil](/molmil-images/mine/4gev) | E. coli thymidylate synthase Y209W variant in complex with substrate and a cofactor analog | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, Thymidylate synthase | Authors: | Newby, Z, Lee, T.T, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2012-08-02 | Release date: | 2012-08-29 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J.Am.Chem.Soc., 134, 2012
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6AND
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![BU of 6and by Molmil](/molmil-images/mine/6and) | Pinatuzumab Fab in complex with anti-Kappa VHH domain | Descriptor: | Anti-kappa VHH domain, GLYCEROL, Pinatuzumab Fab Heavy chain, ... | Authors: | Ereno-Orbea, J, Sicard, T, Julien, J.-P. | Deposit date: | 2017-08-12 | Release date: | 2018-01-31 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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6ANI
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![BU of 6ani by Molmil](/molmil-images/mine/6ani) | Coltuximab Fab in complex with anti-Kappa VHH domain | Descriptor: | Anti-Kappa VHH domain, Coltuximab Fab heavy chain, Coltuximab Fab light chain, ... | Authors: | Ereno Orbea, J, Sicard, T, Julien, J.-P. | Deposit date: | 2017-08-13 | Release date: | 2018-01-31 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments. J. Mol. Biol., 430, 2018
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6D1R
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![BU of 6d1r by Molmil](/molmil-images/mine/6d1r) | Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom | Descriptor: | Ribonuclease P protein component | Authors: | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | Deposit date: | 2018-04-12 | Release date: | 2018-09-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.995 Å) | Cite: | Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6CZK
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![BU of 6czk by Molmil](/molmil-images/mine/6czk) | Crystal structure of wild-type human pro-cathepsin H | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Pro-cathepsin H, ... | Authors: | Huang, X, Hao, Y. | Deposit date: | 2018-04-09 | Release date: | 2018-08-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Crystal structures of human procathepsin H. PLoS ONE, 13, 2018
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1GJH
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![BU of 1gjh by Molmil](/molmil-images/mine/1gjh) | HUMAN BCL-2, ISOFORM 2 | Descriptor: | PROTEIN (APOPTOSIS REGULATOR BCL-2 WITH PUTATIVE FLEXIBLE LOOP REPLACED WITH A PORTION OF APOPTOSIS REGULATOR BCL-X PROTEIN) | Authors: | Petros, A.M, Medek, A, Nettesheim, D.G, Kim, D.H, Yoon, H.S, Swift, K, Matayoshi, E.D, Oltersdorf, T, Fesik, S.W. | Deposit date: | 2001-05-31 | Release date: | 2001-06-13 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure of the antiapoptotic protein bcl-2. Proc.Natl.Acad.Sci.USA, 98, 2001
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8BAL
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8BDP
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8BBL
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![BU of 8bbl by Molmil](/molmil-images/mine/8bbl) | SGL a GH20 family sulfoglycosidase | Descriptor: | Beta-N-acetylhexosaminidase | Authors: | Dong, M.D, Roth, C.R, Jin, Y.J. | Deposit date: | 2022-10-13 | Release date: | 2023-01-11 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.711 Å) | Cite: | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 2022
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6BOG
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![BU of 6bog by Molmil](/molmil-images/mine/6bog) | Crystal structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription | Descriptor: | RNA polymerase-associated protein RapA, SULFATE ION | Authors: | Shaw, G.X, Gan, J, Zhou, Y.N, Zhang, R, Joachimiak, A, Jin, D.J, Ji, X. | Deposit date: | 2017-11-20 | Release date: | 2017-12-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.205 Å) | Cite: | Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription. Structure, 16, 2008
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6BWX
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6BX0
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6BX1
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