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7WLL
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BU of 7wll by Molmil
CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ)
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1~{H}-benzimidazol-2-one, ...
Authors:He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y.
Deposit date:2022-01-13
Release date:2022-05-04
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
7WLJ
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BU of 7wlj by Molmil
CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB)
Descriptor: (1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y.
Deposit date:2022-01-13
Release date:2022-05-04
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
7X5V
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BU of 7x5v by Molmil
NaVEh Sodium channel, and NaVEh from the coccolithophore Emiliania huxleyi
Descriptor: ion channel, ion channel,GFP-TwinStrep
Authors:Jiang, D, Zhang, J.
Deposit date:2022-03-05
Release date:2022-06-01
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:N-type fast inactivation of a eukaryotic voltage-gated sodium channel.
Nat Commun, 13, 2022
8WOY
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BU of 8woy by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 RBD in complex with rabbit ACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ...
Authors:Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F.
Deposit date:2023-10-08
Release date:2023-12-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency.
Mbio, 15, 2024
8WOZ
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BU of 8woz by Molmil
Cryo-EM structure of SARS-CoV RBD in complex with rabbit ACE2
Descriptor: Angiotensin-converting enzyme, Spike protein S1, ZINC ION
Authors:Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F.
Deposit date:2023-10-08
Release date:2023-12-13
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency.
Mbio, 15, 2024
8WOX
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BU of 8wox by Molmil
Cryo-EM structure of SARS-CoV-2 prototype RBD in complex with rabbit ACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike protein S1, ...
Authors:Li, L.J, Shi, K.Y, Yu, G.H, Gao, G.F.
Deposit date:2023-10-08
Release date:2023-12-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Structural basis of increased binding affinities of spikes from SARS-CoV-2 Omicron variants to rabbit and hare ACE2s reveals the expanding host tendency.
Mbio, 15, 2024
7UD7
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BU of 7ud7 by Molmil
Crystal structure of deoxygenated hemoglobin in complex with 5HMF-NO at 1.8 Angstrom
Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Donkor, A.K, Musayev, F.N, Safo, M.K.
Deposit date:2022-03-18
Release date:2022-03-30
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease.
Biomolecules, 12, 2022
7UD8
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BU of 7ud8 by Molmil
Crystal structure of carbon monoxy Hemoglobin in complex with 5HMF at 1.8 Angstrom
Descriptor: (5-methylfuran-2-yl)methanol, Hemoglobin subunit alpha, Hemoglobin subunit beta, ...
Authors:Donkor, A.K, Musayev, F.N, Safo, M.S.
Deposit date:2022-03-18
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease.
Biomolecules, 12, 2022
7XQ8
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BU of 7xq8 by Molmil
Structure of human B-cell antigen receptor of the IgM isotype
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, ...
Authors:Chen, M.Y, Su, Q, Shi, Y.G.
Deposit date:2022-05-07
Release date:2022-08-17
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the human IgM B cell receptor.
Science, 377, 2022
7WLI
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BU of 7wli by Molmil
CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo)
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:He, L, Yu, Z, Dong, Y, Chen, Q, Zhao, Y.
Deposit date:2022-01-13
Release date:2022-05-04
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure, gating, and pharmacology of human Ca V 3.3 channel.
Nat Commun, 13, 2022
6B3W
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BU of 6b3w by Molmil
Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
Descriptor: 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit,Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ...
Authors:Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E.
Deposit date:2017-09-25
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J. Med. Chem., 61, 2018
3WDO
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BU of 3wdo by Molmil
Structure of E. coli YajR transporter
Descriptor: MFS Transporter
Authors:Jiang, D.
Deposit date:2013-06-19
Release date:2013-08-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A
Proc.Natl.Acad.Sci.USA, 110, 2013
6J11
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BU of 6j11 by Molmil
MERS-CoV spike N-terminal domain and 7D10 scFv complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-terminal domain of Spike glycoprotein, ...
Authors:Zhou, H, Zhang, S, Zhang, S, Tang, W, Wang, X.
Deposit date:2018-12-27
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein.
Nat Commun, 10, 2019
8G13
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BU of 8g13 by Molmil
CryoEM structure of cytosolic GAPDH under 8h Oxidative Stress
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G12
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BU of 8g12 by Molmil
CryoEM structure of nuclear GAPDH under 8h Oxidative Stress
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.17 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G16
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BU of 8g16 by Molmil
CryoEM structure of cytoplasmic GAPDH under 24h Oxidative Stress
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.07 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G17
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BU of 8g17 by Molmil
CryoEM structure of wild-type GAPDH
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G14
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BU of 8g14 by Molmil
CryoEM structure of cytosolic GAPDH under 8h Oxidative Stress, class2
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
8G15
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BU of 8g15 by Molmil
CryoEM structure of nuclear GAPDH under 24h Oxidative Stress
Descriptor: Glyceraldehyde-3-phosphate dehydrogenase
Authors:Choi, W.Y, Wu, H, Cheng, Y.F.
Deposit date:2023-02-01
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.07 Å)
Cite:Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.
Proc.Natl.Acad.Sci.USA, 120, 2023
1FDK
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BU of 1fdk by Molmil
CARBOXYLIC ESTER HYDROLASE (PLA2-MJ33 INHIBITOR COMPLEX)
Descriptor: 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL, CALCIUM ION, PHOSPHOLIPASE A2
Authors:Sundaralingam, M.
Deposit date:1997-09-04
Release date:1998-10-14
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
Biochemistry, 36, 1997
8J77
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BU of 8j77 by Molmil
Human high-affinity choline transporter CHT1 in the choline-bound inward-facing occluded conformation
Descriptor: CHOLINE ION, High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gao, Y, Qiu, Y, Zhao, Y.
Deposit date:2023-04-27
Release date:2024-04-10
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
8J75
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BU of 8j75 by Molmil
Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, monomeric state
Descriptor: (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gao, Y, Qiu, Y, Zhao, Y.
Deposit date:2023-04-27
Release date:2024-04-10
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
8J76
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BU of 8j76 by Molmil
Human high-affinity choline transporter CHT1 in the inward-facing apo-open conformation
Descriptor: High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gao, Y, Qiu, Y, Zhao, Y.
Deposit date:2023-04-27
Release date:2024-04-10
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
8J74
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BU of 8j74 by Molmil
Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state
Descriptor: (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ...
Authors:Gao, Y, Qiu, Y, Zhao, Y.
Deposit date:2023-04-27
Release date:2024-04-03
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Transport mechanism of presynaptic high-affinity choline uptake by CHT1.
Nat.Struct.Mol.Biol., 31, 2024
6ZH7
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BU of 6zh7 by Molmil
Crystal structure of fatty acid photodecarboxylase in the dark state determined by serial femtosecond crystallography at room temperature
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Fatty acid photodecarboxylase, chloroplastic, ...
Authors:Hadjidemetriou, K, Coquelle, N, Weik, M, Schlichting, I, Barends, T.R.M, Colletier, J.P.
Deposit date:2020-06-21
Release date:2021-04-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism and dynamics of fatty acid photodecarboxylase.
Science, 372, 2021

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数据于2024-11-06公开中

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