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8Q31
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BU of 8q31 by Molmil
Crystal structure of YTHDC1 in complex with Compound 12 (ZA_341)
Descriptor: 9-[(2-aminophenyl)methyl]-2-chloranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 12 (ZA_341)
To Be Published
8Q4V
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BU of 8q4v by Molmil
Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356)
Descriptor: 2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-cyclopropyl-7,8-dihydropurin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356)
To Be Published
8Q2S
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Crystal structure of YTHDC1 in complex with Compound 4 (ZA_232)
Descriptor: 2-chloranyl-~{N}-methyl-9-phenyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 4 (ZA_232)
To Be Published
8Q2T
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BU of 8q2t by Molmil
Crystal structure of YTHDC1 in complex with Compound 5 (ZA_236)
Descriptor: 2-chloranyl-~{N}-methyl-9-(phenylmethyl)purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 5 (ZA_236)
To Be Published
8Q2W
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Crystal structure of YTHDC1 in complex with Compound 8 (CS_01)
Descriptor: 2-chloranyl-9-(cyclohexylmethyl)-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 8 (CS_01)
To Be Published
8Q38
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Crystal structure of YTHDC1 in complex with Compound 19 (ZA_347)
Descriptor: SULFATE ION, YTH domain-containing protein 1, methyl 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzoate
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 19 (ZA_347)
To Be Published
8Q2U
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Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
Descriptor: 2-chloranyl-~{N}-methyl-9-(pyridin-4-ylmethyl)purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
To Be Published
8Q4P
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Crystal structure of YTHDC1 in complex with Compound 27 (ZA_309)
Descriptor: 2-chloranyl-9-[(3-methoxyphenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 27 (ZA_309)
To Be Published
8Q4T
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BU of 8q4t by Molmil
Crystal structure of YTHDC1 in complex with Compound 31 (ZA_400)
Descriptor: SULFATE ION, YTH domain-containing protein 1, ~{N}-[4-chloranyl-2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanesulfonamide
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 31 (ZA_400)
To Be Published
8Q2V
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Crystal structure of YTHDC1 in complex with Compound 7 (ZA_560)
Descriptor: 2-chloranyl-~{N}-methyl-9-[(2~{S})-oxan-2-yl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 7 (ZA_560)
To Be Published
8Q4N
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Crystal structure of YTHDC1 in complex with Compound 26 (ZA_513)
Descriptor: 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzenecarbonitrile, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 26 (ZA_513)
To Be Published
8Q2Y
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Crystal structure of YTHDC1 in complex with Compound 11 (ZA_572)
Descriptor: 2-[2-chloranyl-6-(methylamino)purin-9-yl]-~{N}-phenyl-ethanamide, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 11 (ZA_572)
To Be Published
8Q3A
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Crystal structure of YTHDC1 in complex with Compound 22 (ZA_393)
Descriptor: 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzamide, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 22 (ZA_393)
To Be Published
8Q37
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BU of 8q37 by Molmil
Crystal structure of YTHDC1 in complex with Compound 18 (ZA_312)
Descriptor: 2-chloranyl-9-[(2-methoxyphenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 18 (ZA_312)
To Be Published
8Q4M
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BU of 8q4m by Molmil
Crystal structure of YTHDC1 in complex with Compound 25 (ZA_349)
Descriptor: 2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 25 (ZA_349)
To Be Published
8Q4R
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Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326)
Descriptor: SULFATE ION, YTH domain-containing protein 1, [4-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanol
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 30 (ZA_326)
To Be Published
8Q33
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Crystal structure of YTHDC1 in complex with Compound 15 (ZA_343)
Descriptor: SULFATE ION, YTH domain-containing protein 1, ~{N}-[2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]-2,2,2-tris(fluoranyl)ethanamide
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 15 (ZA_343)
To Be Published
8Q2R
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BU of 8q2r by Molmil
Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431)
Descriptor: 5-chloranyl-~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Li, Y, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431)
To Be Published
8Q35
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Crystal structure of YTHDC1 in complex with Compound 16 (ZA_354)
Descriptor: 9-[[2-[bis(fluoranyl)methyl]phenyl]methyl]-2-chloranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 16 (ZA_354)
To Be Published
8Q39
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Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515)
Descriptor: 2-chloranyl-N-methyl-9-[[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-03
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515)
To Be Published
8Q3G
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Crystal structure of YTHDC1 in complex with Compound 23 (ZA_385)
Descriptor: 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]-~{N}-methyl-benzamide, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-04
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 23 (ZA_385)
To Be Published
8Q4Q
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Crystal structure of YTHDC1 in complex with Compound 29 (ZA_337)
Descriptor: 4-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzoic acid, SULFATE ION, YTH domain-containing protein 1
Authors:Bedi, R.K, Zalesak, F, Caflisch, A.
Deposit date:2023-08-07
Release date:2023-12-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of YTHDC1 in complex with Compound 29 (ZA_337)
To Be Published
5E73
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BU of 5e73 by Molmil
Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH47
Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide
Authors:Lolli, G, Spiliotopoulos, D, Unzue, A, Nevado, C, Caflisch, A.
Deposit date:2015-10-11
Release date:2015-10-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
5E74
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Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH50
Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)-3-(trifluoromethyl)benzamide
Authors:Lolli, G, Spiliotopoulos, D, Dolbois, A, Nevado, C, Caflisch, A.
Deposit date:2015-10-11
Release date:2015-10-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.783 Å)
Cite:The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
6EKQ
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Crystal structure of the human BRPF1 bromodomain complexed with BZ054 in space group C2
Descriptor: NITRATE ION, Peregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-09-26
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018

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数据于2024-05-29公开中

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