3WGW
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![BU of 3wgw by Molmil](/molmil-images/mine/3wgw) | Structure of PCNA bound to a small molecule inhibitor | Descriptor: | 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION | Authors: | Hashimoto, H. | Deposit date: | 2013-08-12 | Release date: | 2014-02-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014
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3WDO
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![BU of 3wdo by Molmil](/molmil-images/mine/3wdo) | Structure of E. coli YajR transporter | Descriptor: | MFS Transporter | Authors: | Jiang, D. | Deposit date: | 2013-06-19 | Release date: | 2013-08-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A Proc.Natl.Acad.Sci.USA, 110, 2013
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3ULV
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![BU of 3ulv by Molmil](/molmil-images/mine/3ulv) | Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab1068 heavy chain, ... | Authors: | Luo, J, Gilliland, G.L, Obmolova, O, Malia, T, Teplyakov, A. | Deposit date: | 2011-11-11 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.522 Å) | Cite: | Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure. J.Mol.Biol., 421, 2012
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3ULU
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![BU of 3ulu by Molmil](/molmil-images/mine/3ulu) | Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab1068 heavy chain, ... | Authors: | Luo, J, Gilliland, G.L, Obmolova, O, Malia, T, Teplyakov, A. | Deposit date: | 2011-11-11 | Release date: | 2012-05-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.52 Å) | Cite: | Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure. J.Mol.Biol., 421, 2012
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8IPT
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![BU of 8ipt by Molmil](/molmil-images/mine/8ipt) | |
8IPS
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![BU of 8ips by Molmil](/molmil-images/mine/8ips) | |
8IPR
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![BU of 8ipr by Molmil](/molmil-images/mine/8ipr) | |
8IPQ
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![BU of 8ipq by Molmil](/molmil-images/mine/8ipq) | |
4L0U
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![BU of 4l0u by Molmil](/molmil-images/mine/4l0u) | Crystal structure of Plasmodium vivax Prx1a | Descriptor: | 2-Cys peroxiredoxin, putative, ACETATE ION | Authors: | Gretes, M.C, Karplus, P.A. | Deposit date: | 2013-06-01 | Release date: | 2016-11-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Observed octameric assembly of a Plasmodium yoelii peroxiredoxin can be explained by the replacement of native "ball-and-socket" interacting residues by an affinity tag. Protein Sci., 22, 2013
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3EOZ
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![BU of 3eoz by Molmil](/molmil-images/mine/3eoz) | Crystal Structure of Phosphoglycerate Mutase from Plasmodium Falciparum, PFD0660w | Descriptor: | GLYCEROL, PHOSPHATE ION, putative Phosphoglycerate mutase | Authors: | Wernimont, A.K, Tempel, W, Lam, A, Zhao, Y, Lew, J, Lin, Y.H, Wasney, G, Vedadi, M, Kozieradzki, I, Cossar, D, Schapira, M, Weigelt, J, Arrowsmith, C.H, Bochkarev, A, Edwards, A.M, Hui, R, Pizarro, J, Hills, T, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-29 | Release date: | 2008-11-25 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterization of a new phosphatase from Plasmodium. Mol.Biochem.Parasitol., 179, 2011
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5C3U
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![BU of 5c3u by Molmil](/molmil-images/mine/5c3u) | Crystal structure of a fungal L-serine ammonia-lyase from Rhizomucor miehei | Descriptor: | L-serine ammonia-lyase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Zhen, Q, Qiaojuan, Y, Shaoqing, Y, Zhengqiang, J. | Deposit date: | 2015-06-17 | Release date: | 2015-12-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structure and characterization of a novel l-serine ammonia-lyase from Rhizomucor miehei. Biochem.Biophys.Res.Commun., 466, 2015
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5XP0
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![BU of 5xp0 by Molmil](/molmil-images/mine/5xp0) | |
5XSY
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![BU of 5xsy by Molmil](/molmil-images/mine/5xsy) | Structure of the Nav1.4-beta1 complex from electric eel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | Authors: | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | Deposit date: | 2017-06-15 | Release date: | 2017-08-09 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the Nav1.4-beta 1 Complex from Electric Eel. Cell, 170, 2017
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6NJS
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![BU of 6njs by Molmil](/molmil-images/mine/6njs) | Stat3 Core in complex with compound SD36 | Descriptor: | Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name) | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2019-01-04 | Release date: | 2019-12-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell, 36, 2019
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8K4F
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![BU of 8k4f by Molmil](/molmil-images/mine/8k4f) | DHODH in complex with compound A0 | Descriptor: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ... | Authors: | Jian, L, Sun, Q. | Deposit date: | 2023-07-18 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66, 2023
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6M7L
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![BU of 6m7l by Molmil](/molmil-images/mine/6m7l) | Complex of OxyA with the X-domain from GPA biosynthesis | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 hydroxylase, Putative non-ribosomal peptide synthetase | Authors: | Greule, A, Izore, T, Tailhades, J, Peschke, M, Schoppet, M, Ahmed, I, Kulik, A, Adamek, M, Ziemert, N, De Voss, J, Stegmann, E, Cryle, M.J. | Deposit date: | 2018-08-20 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.648297 Å) | Cite: | Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nat Commun, 10, 2019
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6NUQ
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![BU of 6nuq by Molmil](/molmil-images/mine/6nuq) | Stat3 Core in complex with compound SI109 | Descriptor: | Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name) | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2019-02-01 | Release date: | 2019-12-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell, 36, 2019
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7JI3
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![BU of 7ji3 by Molmil](/molmil-images/mine/7ji3) | |
3EFZ
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![BU of 3efz by Molmil](/molmil-images/mine/3efz) | Crystal Structure of a 14-3-3 protein from cryptosporidium parvum (cgd1_2980) | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein | Authors: | Wernimont, A.K, Dong, A, Qiu, W, Lew, J, Wasney, G.A, Vedadi, M, Kozieradzki, I, Zhao, Y, Ren, H, Alam, Z, Lin, Y.H, Sundstrom, M, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | Deposit date: | 2008-09-10 | Release date: | 2008-09-23 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
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3H5Z
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![BU of 3h5z by Molmil](/molmil-images/mine/3h5z) | Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA | Descriptor: | 1,2-ETHANEDIOL, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, ... | Authors: | Qiu, W, Hutchinson, A, Lin, Y.-H, Wernimont, A, Mackenzie, F, Ravichandran, M, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Fairlamb, A.H, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2009-04-22 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature, 464, 2010
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2F6I
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![BU of 2f6i by Molmil](/molmil-images/mine/2f6i) | Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum | Descriptor: | ATP-dependent CLP protease, putative | Authors: | Mulichak, A, Loppnau, P, Bray, J, Amani, M, Vedadi, M, Wasney, G, Finerty, P, Sundstrom, M, Weigelt, J, Edwards, A, Arrowsmith, C, Hui, R, Plotnikova, O, Structural Genomics Consortium (SGC) | Deposit date: | 2005-11-29 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum. J.Mol.Biol., 404, 2010
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2FBN
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![BU of 2fbn by Molmil](/molmil-images/mine/2fbn) | Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain | Descriptor: | 70 kDa peptidylprolyl isomerase, putative | Authors: | Dong, A, Lew, J, Koeieradzki, I, Sundararajan, E, Melone, M, Wasney, G, Zhao, Y, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Hills, T, Structural Genomics Consortium (SGC) | Deposit date: | 2005-12-09 | Release date: | 2006-01-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci., 18, 2009
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8JSW
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![BU of 8jsw by Molmil](/molmil-images/mine/8jsw) | Human VMAT2 complex with serotonin | Descriptor: | SEROTONIN, Synaptic vesicular amine transporter | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-20 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JTA
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![BU of 8jta by Molmil](/molmil-images/mine/8jta) | Human VMAT2 complex with tetrabenazine | Descriptor: | Synaptic vesicular amine transporter, tetrabenazine | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JTC
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![BU of 8jtc by Molmil](/molmil-images/mine/8jtc) | Human VMAT2 complex with reserpine | Descriptor: | Synaptic vesicular amine transporter, reserpine | Authors: | Jiang, D.H, Wu, D. | Deposit date: | 2023-06-21 | Release date: | 2023-11-29 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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